Target Information

Target General Infomation
Target ID
T59328
Former ID
TTDS00355
Target Name
Epidermal growth factor receptor
Gene Name
EGFR
Synonyms
EGFR-TK; Epidermal growth factor receptor ErbB-1; Epidermal growth factor receptor-tyrosine kinase; Receptor protein-tyrosine kinase ErbB-1; Proto-oncogene c-ErbB-1; EGFR
Target Type
Successful
Disease Advanced cancers [ICD9: 140-229; ICD10: C00-C96]
Adult primary hepatocellular carcinoma [ICD10: C22]
Brain cancer [ICD9: 191, 225.0; ICD10: C71, D33]
Brain cancer; Glioblastoma multiforme [ICD9:191, 225.0; ICD10: C71, D33]
Breast cancer [ICD9: 174, 175; ICD10: C50]
Colorectal cancer; Head and neck cancer [ICD9: 140-149, 153, 154; ICD10: C18-C21, C07-C14, C32-C33]
Colon cancer; Glioma; Breast cancer; Head and neck cancer [ICD9: 140-149, 140-229, 183, 191; ICD10: C00-C96, C07-C14, C32, C33, C56, C71]
Chronic pain [ICD9: 338.2,780; ICD10: R52.1-R52.2, G89]
Colorectal cancer [ICD9: 153, 154; ICD10: C18-C21]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Chronic lymphocytic leukaemia [ICD10: C91]
Cryptosporidium infection [ICD10: A07.2]
Colorectal cancer; Squamous Non-small-cell lung cancer [ICD9:153, 154, 140-229, 162, 204.0; ICD10: C18-C21, C33, C33-C34, C34, C91.0]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Diabetic foot ulcer [ICD9: 707; ICD10: L88-L89]
Esophageal cancer [ICD9: 150; ICD10: C15]
Glioblastoma multiforme [ICD9: 191; ICD10: C71]
Gastric cancer [ICD9: 151; ICD10: C16]
Gastrointestinal disease [ICD10: K00-K93]
Glioma [ICD9: 191; ICD10: C71]
Gastric cancer; Non-small cell lung cancer [ICD9:151; ICD10: C16, C33-C34]
Head and neck cancer [ICD9: 140-149, 140-229; ICD10: C07-C14, C32-C33]
Head and neck squamous cell carcinoma [ICD9: 199; ICD10: C44]
Inflammatory breast cancer [ICD9: 174, 175; ICD10: C50]
Ischemia [ICD9: 459.89; ICD10: I99.8]
Lymphoma [ICD9: 202.8, 208.9; ICD10: C81-C86]
Locally advanced head and neck cancer [ICD9: 140-149; ICD10: C07-C14, C32, C33]
Lung cancer [ICD9: 162; ICD10: C33-C34]
Melanoma [ICD9: 172; ICD10: C43]
Metastatic colorectal cancer [ICD9: 153, 154; ICD10: C18-C21]
Malignant tumor [ICD9: 140-199; ICD10: C00-C75, C7A, C7B]
Metastatic epithelial tumors [ICD9: 140-199; ICD10: C00-C75, C7A, C7B]
Non-small cell lung cancer; Metastatic colorectal cancer [ICD9:153, 154; ICD10: C33-C34, C18-C21]
Non-small cell lung cancer [ICD10: C33-C34]
Ovarian cancer [ICD9: 183; ICD10: C56]
Psoriasis [ICD9: 696; ICD10: L40]
Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10: C25]
Refractory breast cancer [ICD9: 174, 175; ICD10: C50]
Recurrent squamous cell carcinoma of the hypopharynx [ICD10: D37]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Urethral cancer; Bladder cancer; Ovarian cancer; Prostate cancer; Breast cancer [ICD9: 140-229, 174, 175, 183, 188; ICD10: C50, C56, C67]
Vulnerary [ICD10: S00-T98]
Unspecified [ICD code not available]
Function
Receptor for egf, but also for other members of the egf family, as tgf-alpha, amphiregulin, betacellulin, heparin-binding egf-like growth factor, gp30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.
BioChemical Class
Kinase
Target Validation
T59328
UniProt ID
P00533
EC Number
EC 2.7.10.1
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
Drugs and Mode of Action
Drug(s) BIBW 2992 Drug Info Approved Non-small cell lung cancer [1], [2]
Cetuximab Drug Info Approved Colorectal cancer [3], [4]
DWP-401 Drug Info Approved Diabetic foot ulcer [5]
Epidermal growth factor Drug Info Approved Vulnerary [6]
Erlotinib Drug Info Approved Non-small cell lung cancer [7], [3]
Gefitinib Drug Info Approved Cancer [8], [9]
HEGF Drug Info Approved Diabetic foot ulcer [5]
Lapatinib Drug Info Approved Breast cancer [10], [11]
Necitumumab Drug Info Approved Colorectal cancer; Squamous Non-small-cell lung cancer [12], [13]
Panitumumab Drug Info Approved Colorectal cancer [14], [15]
SKI-758 Drug Info Approved Ischemia [16], [6]
Tyverb/Tykerb Drug Info Approved Refractory breast cancer [17]
Vandetanib Drug Info Approved Solid tumours [18], [19]
Icotinib hydrochloride Drug Info Registered Non-small cell lung cancer [20], [21], [22]
AZD9291 Drug Info Phase 3 Melanoma [23], [24]
Bevacizumab + Erlotinib Drug Info Phase 3 Non-small cell lung cancer; Metastatic colorectal cancer [25], [26]
CO-1686 Drug Info Phase 3 Non-small cell lung cancer [27], [28]
Dacomitinib Drug Info Phase 3 Non-small cell lung cancer [29], [30]
DE-766 Drug Info Phase 3 Gastric cancer; Non-small cell lung cancer [31], [32]
Erlotinib Drug Info Phase 3 Pancreatic cancer [7], [33]
Gefitinib Drug Info Phase 3 Head and neck cancer [8], [9]
HKI-272 Drug Info Phase 3 Breast cancer [34]
Rindopepimut Drug Info Phase 3 Brain cancer; Glioblastoma multiforme [35]
Tyverb/Tykerb Drug Info Phase 3 Gastric cancer [17]
Zalutumumab Drug Info Phase 3 Head and neck cancer [36]
Indium-111 Drug Info Phase 2/3 Solid tumours [37]
ABT-414 Drug Info Phase 2 Glioblastoma multiforme [38], [39]
ABX-EGF Drug Info Phase 2 Discovery agent [40]
ASP8273 Drug Info Phase 2 Non-small cell lung cancer [41]
Bevacizumab + Erlotinib Drug Info Phase 2 Adult primary hepatocellular carcinoma [42], [43], [44], [45], [46], [47]
BMS-599626 Drug Info Phase 2 Solid tumours [48], [49]
BMS-690514 Drug Info Phase 2 Chronic pain [50]
CetuGEX Drug Info Phase 2 Cancer [51]
CI-1033 Drug Info Phase 2 Lymphoma [52], [53]
Erlotinib Drug Info Phase 2 Colon cancer; Glioma; Breast cancer; Head and neck cancer [7], [33]
Gefitinib Drug Info Phase 2 Urethral cancer; Bladder cancer; Ovarian cancer; Prostate cancer; Breast cancer [8], [9]
HER1-VSSP vaccine Drug Info Phase 2 Cancer [54], [55]
HM-78136B Drug Info Phase 2 Solid tumours [56], [57]
Matuzumab Drug Info Phase 2 Gastric cancer [58]
MEHD-7945A Drug Info Phase 2 Solid tumours [59]
MEHD7945A Drug Info Phase 2 Colorectal cancer; Head and neck cancer [59], [60]
Panitumumab Drug Info Phase 2 Locally advanced head and neck cancer [61], [15]
Pazopanib + Tyverb/Tykerb Drug Info Phase 2 Inflammatory breast cancer [62]
Pelitinib Drug Info Phase 2 Lymphoma [63], [64]
SYM-004 Drug Info Phase 2 Head and neck cancer [65]
TT-100 Drug Info Phase 2 Non-small cell lung cancer [66]
Tyverb/Tykerb Drug Info Phase 2 Head and neck squamous cell carcinoma [17]
VATALANIB Drug Info Phase 2 Solid tumours [67], [68]
Bevacizumab + Erlotinib Drug Info Phase 1/2 Recurrent squamous cell carcinoma of the hypopharynx [69]
EGF816 Drug Info Phase 1/2 Non-small cell lung cancer [70]
EMD 55900 Drug Info Phase 1/2 Glioma [71]
SN-32793 Drug Info Phase 1/2 Non-small cell lung cancer [72]
Varlitinib Drug Info Phase 1/2 Breast cancer [73], [74]
S-222611 Drug Info Phase 1b Malignant tumor [75]
AMG 595 Drug Info Phase 1 Glioblastoma multiforme [76]
Anti-HER3/EGFR DAF Drug Info Phase 1 Metastatic epithelial tumors [77]
AST-1306 Drug Info Phase 1 Cancer [78]
BIBX-1382 Drug Info Phase 1 Chronic lymphocytic leukaemia [79], [80]
Cipatinib Drug Info Phase 1 Cancer [81]
CUDC-101 Drug Info Phase 1 Solid tumours [82]
HER-2/HER-1 vaccine Drug Info Phase 1 Solid tumours [83]
IMGN289 Drug Info Phase 1 Solid tumours [84]
JNJ-26483327 Drug Info Phase 1 Cancer [85]
LY3164530 Drug Info Phase 1 Advanced cancers [86]
MR1-1 Drug Info Phase 1 Brain cancer [87]
111In-hEGF Drug Info Preclinical Breast cancer [88], [89]
EGFR/IGFR tandem adnectin Drug Info Preclinical Cancer [90]
PKI166 Drug Info Discontinued in Phase 2 Esophageal cancer [91], [92]
RG7160 Drug Info Discontinued in Phase 2 Metastatic colorectal cancer [93]
AZD4769 Drug Info Discontinued in Phase 1 Solid tumours [94]
PD-153035 Drug Info Discontinued in Phase 1 Psoriasis [95]
TAK165 Drug Info Discontinued in Phase 1 Cancer [96], [97]
AZD-9935 Drug Info Terminated Solid tumours [98]
CGP-52411 Drug Info Terminated Cancer [99]
CGP-53353 Drug Info Terminated Discovery agent [100], [101]
Heparin-EGF-like factor Drug Info Terminated Gastrointestinal disease [102], [103]
Inhibitor (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine Drug Info [104]
(3-Bromo-phenyl)-quinazolin-4-yl-amine Drug Info [105]
(E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin Drug Info [106]
(S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate Drug Info [107]
10-hydroxy-18-methoxybetaenone Drug Info [108]
2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile Drug Info [109]
2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile Drug Info [109]
2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile Drug Info [107]
2-cyano-3-(3,4-dihydroxyphenyl)acrylamide Drug Info [107]
2-methoxy-4-(2-nitrovinyl)phenol Drug Info [107]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Drug Info [110]
3,4-diphenyl-1H-pyrrole-2,5-dione Drug Info [110]
3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one Drug Info [111]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione Drug Info [110]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione Drug Info [110]
3-Pyridin-4-yl-quinoline-6,7-diol Drug Info [112]
4-(2-nitroprop-1-enyl)benzene-1,2-diol Drug Info [107]
4-(2-nitrovinyl)benzene-1,2-diol Drug Info [107]
4-(2-nitrovinyl)phenol Drug Info [107]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline Drug Info [113]
4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline Drug Info [113]
4-(3-Bromo-phenylamino)-quinazoline-6,7-diol Drug Info [105]
4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid Drug Info [107]
4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline Drug Info [114]
4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide Drug Info [115]
4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline Drug Info [116]
4557W Drug Info [117]
5,6-Bis-p-tolylamino-isoindole-1,3-dione Drug Info [118]
5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide Drug Info [115]
6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline Drug Info [116]
6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline Drug Info [116]
6,7-diethoxy-4-styrylquinazoline Drug Info [116]
6,7-dimethoxy-4-(2-phenylethynyl)quinazoline Drug Info [116]
6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline Drug Info [116]
6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline Drug Info [116]
6,7-dimethoxy-N-m-tolylquinazolin-4-amine Drug Info [119]
6-chloro-N-(3-chlorophenyl)quinazolin-4-amine Drug Info [120]
AG 112 Drug Info [121]
AG 9 Drug Info [121]
AG-213 Drug Info [114]
AG-538 Drug Info [107]
ASP8273 Drug Info [122]
AZD4769 Drug Info [123]
AZD9291 Drug Info [124]
Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine Drug Info [105]
Benzyl-quinazolin-4-yl-amine Drug Info [104]
Bevacizumab + Erlotinib Drug Info [125]
BIBW 2992 Drug Info [126]
BMS-599626 Drug Info [127], [128]
BMS-690514 Drug Info [129]
BPIQ-I Drug Info [105]
CGP-52411 Drug Info [130]
CGP-53353 Drug Info [118]
CI-1033 Drug Info [128]
CL-387785 Drug Info [119]
Cochliobolic acid Drug Info [131]
compound 38 Drug Info [132]
compound 56 Drug Info [133]
EGF816 Drug Info [134]
EGFR inhibitor Drug Info [135]
EGFR/IGFR tandem adnectin Drug Info [136]
Epitinib Drug Info [137]
Erlotinib Drug Info [138]
Gefitinib Drug Info [139], [140]
HDS-029 Drug Info [141]
HKI-272 Drug Info [142]
HM-61713B Drug Info [137]
HM-78136B Drug Info [143]
HTS-00213 Drug Info [119]
HTS-02876 Drug Info [119]
HTS-05058 Drug Info [135]
IMGN289 Drug Info [144]
JNJ-26483327 Drug Info [145]
Lapatinib Drug Info [146], [147]
LAVENDUSTIN A Drug Info [148]
MDP-01 Drug Info [137]
MT-062 Drug Info [137]
N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine Drug Info [105]
N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine Drug Info [149]
N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine Drug Info [104]
N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine Drug Info [150]
N-(4-(phenylamino)quinazolin-6-yl)acrylamide Drug Info [151]
N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide Drug Info [152]
N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide Drug Info [152]
N4-(3-chlorophenyl)quinazoline-4,6-diamine Drug Info [153]
N4-(3-methylphenyl)-4,6-quinazolinediamine Drug Info [154]
NRC-2694 Drug Info [137]
ON-128 Drug Info [137]
OSI-75 Drug Info [155]
Pazopanib + Tyverb/Tykerb Drug Info [156]
PD-0166326 Drug Info [157]
PD-0173956 Drug Info [157]
PD-0180970 Drug Info [157]
PD-158780 Drug Info [150]
PD-168393 Drug Info [151]
PD182905 Drug Info [158]
PP121 Drug Info [159]
RG-50810 Drug Info [107]
RM-6427 Drug Info [137]
Ro-4396686 Drug Info [160]
S-222611 Drug Info [75]
SKI-758 Drug Info [161]
SN-32793 Drug Info [137]
TAK165 Drug Info [128]
Theliatinib Drug Info [137]
TT-100 Drug Info [162]
TYRPHOSTIN AG-1478 Drug Info [111]
Tyverb/Tykerb Drug Info [156]
Vandetanib Drug Info [128], [123]
VATALANIB Drug Info [142]
WHI-P154 Drug Info [163]
WZ-3146 Drug Info [137]
Modulator 111In-hEGF Drug Info [164]
AGT-2000 Drug Info [137]
AL-6802 Drug Info [137]
AMG 595 Drug Info [165]
Anti-HER3/EGFR DAF Drug Info
AST-1306 Drug Info [166]
Cipatinib Drug Info [167]
CO-1686 Drug Info [168]
CUDC-101 Drug Info [82]
DE-766 Drug Info [137]
Epidermal growth factor Drug Info [137]
Heparin-EGF-like factor Drug Info [102], [103]
Imaging-theranostic nanoemulsion agents Drug Info [137]
LA22-radioimmunoconjugates Drug Info [137]
LY3164530 Drug Info [169]
MEHD-7945A Drug Info [167]
MEHD7945A Drug Info [169]
MG-111 Drug Info
MR1-1 Drug Info [170]
Necitumumab Drug Info [171]
PD-153035 Drug Info
Pelitinib Drug Info
PF 5208766 Drug Info
PKI166 Drug Info
RG7160 Drug Info [172]
Rindopepimut Drug Info [171]
Small-molecule cetuximab binding mimics Drug Info [137]
SYM-011 Drug Info [137]
TGF alpha Drug Info [137]
Varlitinib Drug Info [167]
Antagonist AZD-9935 Drug Info [173]
BIBX-1382 Drug Info [174]
Dacomitinib Drug Info [137]
EDP-13 Drug Info [137]
Icotinib hydrochloride Drug Info [175]
IPS-01003 Drug Info [137]
RX-1792 Drug Info [137]
Activator DWP-401 Drug Info [5]
HEGF Drug Info [5]
Suppressor Panitumumab Drug Info [176]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
DRM DRM Info
Pathways
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Adherens junction
Gap junction
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
EGF receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Signaling events mediated by PTP1B
Arf6 signaling events
Signaling events mediated by TCPTP
Thromboxane A2 receptor signaling
SHP2 signaling
Regulation of Telomerase
EGF receptor (ErbB1) signaling pathway
EGFR-dependent Endothelin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
ErbB1 downstream signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
E-cadherin signaling in keratinocytes
ErbB receptor signaling network
Internalization of ErbB1
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
Syndecan-3-mediated signaling events
Reactome Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
WikiPathways ErbB Signaling Pathway
Regulation of Actin Cytoskeleton
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
Focal Adhesion
Aryl Hydrocarbon Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Cytodifferentiation (Part 3 of 3)
Bladder Cancer
Induction (Part 1 of 3)
Signaling by ERBB4
Signaling by ERBB2
Gastrin-CREB signalling pathway via PKC and MAPK
PIP3 activates AKT signaling
Nanoparticle-mediated activation of receptor signaling
Aryl Hydrocarbon Receptor
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Gastric cancer network 2
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
Arylhydrocarbon receptor (AhR) signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Integrated Breast Cancer Pathway
Signaling by EGFR
L1CAM interactions
References
REF 1BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr Opin Investig Drugs. 2008 Dec;9(12):1336-46.
REF 2(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5667).
REF 32004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
REF 4(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6882).
REF 5Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
REF 6Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
REF 7(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4920).
REF 8(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4941).
REF 9Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
REF 10FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022059.
REF 11(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5692).
REF 12ClinicalTrials.gov (NCT00981058) First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin. U.S. National Institutes of Health.
REF 13(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8090).
REF 142006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
REF 15(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6883).
REF 16Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
REF 17FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022059.
REF 182011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
REF 19(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5717).
REF 20ClinicalTrials.gov (NCT02404675) High Dose Icotinib in Advanced Non-small Cell Lung Cancer Patients With EGFR 21 Exon Positive. U.S. National Institutes of Health.
REF 21(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7641).
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