Drug Information

Drug General Information
Drug ID
D09XIL
Former ID
DNC006432
Drug Name
Ro-4396686
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528018]
Structure
Download
2D MOL

3D MOL
Formula
C24H24FN5O3
Canonical SMILES
COC1=CC=C(C=C1)N2CC3=CN=C(N=C3N(C2=O)C4CCC(C4)O)NC5=CC=<br />C(C=C5)F
InChI
1S/C24H24FN5O3/c1-33-21-10-7-18(8-11-21)29-14-15-13-26-23(27-17-4-2-16(25)3-5-17)28-22(15)30(24(29)32)19-6-9-20(31)12-19/h2-5,7-8,10-11,13,19-20,31H,6,9,12,14H2,1H3,(H,26,27,28)
InChIKey
KXEMINRANVTICS-UHFFFAOYSA-N
PubChem Compound ID
11396738
Target and Pathway
Target(s) FGF-3 receptor Target Info Inhibitor [528018]
Alpha platelet-derived growth factor receptor Target Info Inhibitor [528018]
Fibroblast growth factor receptor 2 Target Info Inhibitor [528018]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [528018]
mRNA of FGFR4 Target Info Inhibitor [528018]
mRNA of PKA Catalytic Subunit C-alpha Target Info Inhibitor [528018]
Fyn tyrosine kinase Target Info Inhibitor [528018]
CAMP-dependent protein kinase type II-beta regulatory chain Target Info Inhibitor [528018]
Protein kinase A Target Info Inhibitor [528018]
Beta platelet-derived growth factor receptor Target Info Inhibitor [528018]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [528018]
Mitogen-activated protein kinase 1 Target Info Inhibitor [528018]
Epidermal growth factor receptor Target Info Inhibitor [528018]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
MicroRNAs in cancer
Bladder cancer
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Focal adhesion
Gap junction
HTLV-I infection
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Regulation of actin cytoskeletonhsa04010:MAPK signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Oocyte meiosis
Apoptosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Hedgehog signaling pathway
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Olfactory transduction
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson's disease
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Amoebiasis
Epstein-Barr virus infection
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathyhsa04071:Sphingolipid signaling pathway
Axon guidance
Osteoclast differentiation
Adherens junction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Pathogenic Escherichia coli infection
Measles
Viral myocarditishsa04210:Apoptosis
Insulin signaling pathwayhsa04010:MAPK signaling pathway
ErbB signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
mTOR signaling pathway
Dorso-ventral axis formation
TGF-beta signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Long-term depression
Prolactin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Thyroid cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Epithelial cell signaling in Helicobacter pylori infection
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_23:TSH Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway FGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathwayP00021:FGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathwayP00021:FGF signaling pathwayP00019:Endothelin signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Inflammation mediated by chemokine and cytokine signaling pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
5HT1 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Histamine H2 receptor mediated signaling pathway
GABA-B receptor II signaling
Dopamine receptor mediated signaling pathway
Enkephalin release
Nicotine pharmacodynamics pathway
CCKR signaling map STP00007:Axon guidance mediated by semaphorins
Cadherin signaling pathway
Integrin signalling pathway
Parkinson diseaseP00019:Endothelin signaling pathway
Hedgehog signaling pathway
Transcription regulation by bZIP transcription factor
Enkephalin releaseP00005:Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
FGF signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Interferon-gamma signaling pathway
Interleukin signaling pathway
PDGF signaling pathway
Parkinson disease
TGF-beta signaling pathway
T cell activation
VEGF signaling pathway
Ras Pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00012:Cadherin signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkfgf_pathway:FGF signaling pathwayhif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkfgf_pathway:FGF signaling pathwaygmcsf_pathway:GMCSF-mediated signaling events
LPA4-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
LKB1 signaling events
Thromboxane A2 receptor signaling
Signaling events mediated by HDAC Class I
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
Syndecan-1-mediated signaling events
Retinoic acid receptors-mediated signaling
Hedgehog signaling events mediated by Gli proteins
VEGFR1 specific signals
Calcium signaling in the CD4+ TCR pathway
Syndecan-2-mediated signaling events
Aurora A signaling
Class I PI3K signaling events mediated by Akt
Alpha4 beta1 integrin signaling eventsfcer1pathway:Fc-epsilon receptor I signaling in mast cells
ErbB4 signaling events
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
Ephrin A reverse signaling
Reelin signaling pathway
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Angiopoietin receptor Tie2-mediated signaling
Netrin-mediated signaling events
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
amb2 Integrin signaling
EPHA forward signaling
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinaseptp1bpathway:Signaling events mediated by PTP1B
S1P3 pathway
Nectin adhesion pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
Signaling events mediated by PRL
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
EPHB forward signaling
Osteopontin-mediated events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
TRAIL signaling pathway
CDC42 signaling events
Regulation of Telomerase
Arf6 downstream pathway
mTOR signaling pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
BMP receptor signaling
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Nongenotropic Androgen signaling
CXCR3-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
Signaling events mediated by focal adhesion kinaselysophospholipid_pathway:LPA receptor mediated events
Arf6 signaling events
EGFR-dependent Endothelin signaling events
Direct p53 effectors
ErbB receptor signaling network
Internalization of ErbB1
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
PathWhiz Pathway Muscle/Heart ContractionPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Reactome FGFR3 mutant receptor activationR-HSA-1257604:PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-2033519:Activated point mutants of FGFR2R-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-109704:PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
Phospholipase C-mediated cascade
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascadeR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Interleukin-3, 5 and GM-CSF signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
Gluconeogenesis
Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin interactions
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
CRMPs in Sema3A signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Dectin-2 family
RAF/MAP kinase cascade
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-163615:PKA activation
Factors involved in megakaryocyte development and platelet productionR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascadeR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
RHO GTPases Activate WASPs and WAVEs
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
Constitutive Signaling by EGFRvIII
WikiPathways Regulation of Actin Cytoskeleton
Endochondral Ossification
Bladder Cancer
Neural Crest Differentiation
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
AngiogenesisWP51:Regulation of Actin Cytoskeleton
Ectoderm Differentiation
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Signaling by FGFR
MicroRNAs in cardiomyocyte hypertrophy
AngiogenesisWP306:Focal Adhesion
Nifedipine Activity
Signaling by VEGF
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by FGFRWP706:SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
MAPK Signaling Pathway
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Human Complement System
DAG and IP3 signaling
Regulation of Water Balance by Renal Aquaporins
Dopamine metabolism
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
miRs in Muscle Cell Differentiation
SREBP signalling
Opioid Signalling
Mitotic G2-G2/M phases
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet production
Nicotine Activity on Dopaminergic NeuronsWP69:TCR Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Kit receptor signaling pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
T-Cell Receptor and Co-stimulatory Signaling
Primary Focal Segmental Glomerulosclerosis FSGS
BDNF signaling pathway
Interleukin-11 Signaling Pathway
B Cell Receptor Signaling Pathway
Pathogenic Escherichia coli infection
TSLP Signaling Pathway
IL-7 Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Platelet Adhesion to exposed collagen
Netrin-1 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wallWP706:SIDS Susceptibility Pathways
Factors involved in megakaryocyte development and platelet productionWP51:Regulation of Actin Cytoskeleton
PDGF Pathway
Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
Signaling by FGFRWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
Vitamin A and Carotenoid Metabolism
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
ErbB Signaling Pathway
Senescence and Autophagy in Cancer
EPO Receptor Signaling
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
IL-4 Signaling Pathway
TGF beta Signaling Pathway
IL-6 signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Apoptosis-related network due to altered Notch3 in ovarian cancer
MAP kinase activation in TLR cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
EBV LMP1 signaling
Signal Transduction of S1P Receptor
Aryl Hydrocarbon Receptor
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
IL-9 Signaling Pathway
Endothelin Pathways
IL17 signaling pathway
Alzheimers Disease
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
Integrated Breast Cancer Pathway
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Type II diabetes mellitus
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
Aryl Hydrocarbon Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Signaling by ERBB4
Signaling by ERBB2
Gastrin-CREB signalling pathway via PKC and MAPK
Gastric cancer network 2
Arylhydrocarbon receptor (AhR) signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signaling by EGFR
References
Ref 528018Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
Ref 528018Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

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