| Drug General Information |
| Drug ID |
D0H3UI
|
| Former ID |
DIB018768
|
| Drug Name |
AG 9
|
| Synonyms |
tyrphostin 1; tyrphostin A1; AG9; AG-9
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C11H8N2O
|
| InChI |
InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
|
| InChIKey |
UOHFCPXBKJPCAD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
68156, 498636, 625241, 880412, 3155871, 3288453, 6490739, 8033994, 8151406, 11111909, 11121784, 11122264, 11362952, 11365514, 11368076, 11371075, 11371076, 11373677, 11376238, 11381974, 14940884, 17405706, 24278751, 26753655, 26753656, 26759678, 29221243, 47191359, 47216587, 47810558, 47885217, 48110260, 48184803, 48334278, 49761253, 49761659, 50107071, 50107072, 50107073, 53778256, 53800878, 57697454, 74410099, 85090257, 85231268, 85765136, 85788294, 87225610, 88581421, 90340804
|
| Target and Pathway |
| Target(s) |
Epidermal growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
ErbB signaling pathway
|
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
|
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HIF-1 signaling pathway
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FoxO signaling pathway
|
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Endocytosis
|
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PI3K-Akt signaling pathway
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Dorso-ventral axis formation
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Focal adhesion
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Adherens junction
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Gap junction
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Oxytocin signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
|
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Hepatitis C
|
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Pathways in cancer
|
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Proteoglycans in cancer
|
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MicroRNAs in cancer
|
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Pancreatic cancer
|
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Endometrial cancer
|
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Glioma
|
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Prostate cancer
|
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Melanoma
|
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Bladder cancer
|
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Non-small cell lung cancer
|
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Central carbon metabolism in cancer
|
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Choline metabolism in cancer
|
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NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling Pathway
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PANTHER Pathway
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Cadherin signaling pathway
|
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EGF receptor signaling pathway
|
|
Pathway Interaction Database
|
LPA receptor mediated events
|
|
Signaling events mediated by PTP1B
|
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Arf6 signaling events
|
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Signaling events mediated by TCPTP
|
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Thromboxane A2 receptor signaling
|
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SHP2 signaling
|
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Regulation of Telomerase
|
|
EGF receptor (ErbB1) signaling pathway
|
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EGFR-dependent Endothelin signaling events
|
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Direct p53 effectors
|
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ErbB1 downstream signaling
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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E-cadherin signaling in keratinocytes
|
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ErbB receptor signaling network
|
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Internalization of ErbB1
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Stabilization and expansion of the E-cadherin adherens junction
|
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a6b1 and a6b4 Integrin signaling
|
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Syndecan-3-mediated signaling events
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Reactome
|
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
|
SHC1 events in ERBB2 signaling
|
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PLCG1 events in ERBB2 signaling
|
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PIP3 activates AKT signaling
|
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GRB2 events in EGFR signaling
|
|
GAB1 signalosome
|
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SHC1 events in EGFR signaling
|
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EGFR downregulation
|
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GRB2 events in ERBB2 signaling
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PI3K events in ERBB2 signaling
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EGFR Transactivation by Gastrin
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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Constitutive Signaling by EGFRvIII
|
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RAF/MAP kinase cascade
|
|
WikiPathways
|
ErbB Signaling Pathway
|
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Regulation of Actin Cytoskeleton
|
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EGF/EGFR Signaling Pathway
|
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MAPK Signaling Pathway
|
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Focal Adhesion
|
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Aryl Hydrocarbon Receptor Pathway
|
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Extracellular vesicle-mediated signaling in recipient cells
|
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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Bladder Cancer
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
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Signaling by ERBB4
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Signaling by ERBB2
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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PIP3 activates AKT signaling
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Nanoparticle-mediated activation of receptor signaling
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Aryl Hydrocarbon Receptor
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Gastric cancer network 2
|
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AGE/RAGE pathway
|
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Signaling Pathways in Glioblastoma
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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Integrated Breast Cancer Pathway
|
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Signaling by EGFR
|
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L1CAM interactions
|
| References |
| REF 1 | Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. |
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