Drug Information

Drug General Information
Drug ID
D03EHM
Former ID
DIB020745
Drug Name
PP121
Synonyms
PP-121; PP 121
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529744]
Structure
Download
2D MOL
Formula
C17H17N7
InChI
InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChIKey
NVRXTLZYXZNATH-UHFFFAOYSA-N
PubChem Compound ID
24905142
PubChem Substance ID
53799223, 56261119, 56353025, 57471091, 92758942, 93581181, 99444523, 103742055, 103904782, 104148006, 124360789, 125164702, 125749181, 126731462, 131269001, 135693133, 136349522, 136367653, 138753225, 152258196, 152344262, 160647032, 160969107, 162011837, 162163976, 162202623, 163124448, 163685600, 163782900, 174006540, 174526139, 180387124, 186014823, 189614639, 204361341, 223654516, 223705034, 237356063, 241376688, 242059945, 249565693, 251971066, 252082223, 252157615, 252216107, 252446745, 252450697
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [529744]
Serine/threonine-protein kinase mTOR Target Info Inhibitor [529744]
Proto-oncogene tyrosine-protein kinase SRC Target Info Inhibitor [529744]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [529744]
Phosphoinositide 3 kinase Target Info Inhibitor [529744]
Alpha platelet-derived growth factor receptor Target Info Inhibitor [529744]
mRNA of Abl Target Info Inhibitor [529744]
HCK proto-oncogene, Src family tyrosine kinase Target Info Inhibitor [529744]
PI3K beta Target Info Inhibitor [529744]
Epidermal growth factor receptor Target Info Inhibitor [529744]
BioCyc Pathway Superpathway of inositol phosphate compounds
3-phosphoinositide biosynthesis
KEGG Pathway Non-homologous end-joining
Cell cyclehsa04012:ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
VEGF signaling pathway
Focal adhesion
Adherens junction
Tight junction
Gap junction
Platelet activation
GABAergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Oxytocin signaling pathway
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Tuberculosis
Hepatitis B
Viral carcinogenesis
Proteoglycans in cancerhsa04014:Ras signaling pathway
Cytokine-cytokine receptor interaction
Proteoglycans in cancerhsa00562:Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Progesterone-mediated oocyte maturation
Regulation of lipolysis in adipocytes
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Cell cycle
Axon guidance
Pathogenic Escherichia coli infection
Viral myocarditishsa00562:Inositol phosphate metabolism
Dorso-ventral axis formation
Bladder cancer
Choline metabolism in cancer
NetPath Pathway IL1 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Hypoxia response via HIF activation
Interleukin signaling pathwayP00005:Angiogenesis
Cadherin signaling pathway
Integrin signalling pathway
Parkinson disease
CCKR signaling map STP00005:Angiogenesis
VEGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathwayP00008:Axon guidance mediated by Slit/RoboP00005:Angiogenesis
Apoptosis signaling pathway
Axon guidance mediated by netrin
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
T cell activation
VEGF signaling pathway
p53 pathway
Ras Pathway
p53 pathway feedback loops 2
CCKR signaling map STP00012:Cadherin signaling pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling eventsil4_2pathway:IL4-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL12-mediated signaling events
CDC42 signaling events
LKB1 signaling events
Regulation of Telomerase
mTOR signaling pathway
CXCR4-mediated signaling events
EGFR-dependent Endothelin signaling events
IL2 signaling events mediated by PI3K
IFN-gamma pathway
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
CXCR3-mediated signaling events
Class I PI3K signaling events mediated by Aktendothelinpathway:Endothelins
Signaling events mediated by PRL
LPA receptor mediated events
Atypical NF-kappaB pathway
Glypican 1 network
Plasma membrane estrogen receptor signaling
Signaling events mediated by PTP1B
S1P3 pathway
EPHB forward signaling
Nectin adhesion pathway
Regulation of p38-alpha and p38-beta
Signaling events regulated by Ret tyrosine kinase
Arf6 signaling events
Signaling events mediated by TCPTP
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Netrin-mediated signaling events
Alpha9 beta1 integrin signaling events
EGF receptor (ErbB1) signaling pathway
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Regulation of Androgen receptor activity
E-cadherin signaling in the nascent adherens junction
amb2 Integrin signaling
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
EPHA forward signaling
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
Nongenotropic Androgen signaling
Internalization of ErbB1
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-2-mediated signaling events
Syndecan-3-mediated signaling events
Ephrin B reverse signaling
Trk receptor signaling mediated by PI3K and PLC-gamma
EPHA2 forward signaling
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinasehif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Notch-mediated HES/HEY networkatf2_pathway:ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkp73pathway:p73 transcription factor network
ATM pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma proteinerbb4_pathway:ErbB4 signaling events
TRAIL signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
CXCR3-mediated signaling eventslysophospholipid_pathway:LPA receptor mediated events
Direct p53 effectors
ErbB receptor signaling network
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
PathWhiz Pathway Leucine Stimulation on Insulin SignalingPW000143:Inositol Metabolism
Phosphatidylinositol Phosphate Metabolism
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Nonhomologous End-Joining (NHEJ)R-HSA-1257604:PIP3 activates AKT signaling
Macroautophagy
mTORC1-mediated signalling
HSF1-dependent transactivation
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-109704:PI3K Cascade
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
PI3K/AKT activation
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin interactions
Costimulation by the CD28 family
G beta:gamma signalling through PI3Kgamma
G alpha (q) signalling events
G alpha (12/13) signalling events
Interleukin-3, 5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Interleukin receptor SHC signaling
Regulation of signaling by CBLR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascadeR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet productionR-HSA-109704:PI3K Cascade
Regulation of signaling by CBLR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage ResponseWP673:ErbB Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
Insulin Signaling
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway Netpath
Extracellular vesicle-mediated signaling in recipient cells
Cardiac Hypertrophic Response
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Oncostatin M Signaling Pathway
TSLP Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
TSH signaling pathway
RANKL/RANK Signaling Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Signaling by Insulin receptor
Costimulation by the CD28 family
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
TOR Signaling
AMPK SignalingWP673:ErbB Signaling Pathway
Notch Signaling Pathway
EPO Receptor Signaling
TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Pregnane X Receptor pathway
Aryl Hydrocarbon Receptor Pathway
IL-3 Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Integrated Pancreatic Cancer Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
Arylhydrocarbon receptor (AhR) signaling pathway
Regulation of Microtubule Cytoskeleton
Integrin-mediated Cell Adhesion
Angiogenesis
Androgen receptor signaling pathwayWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP75:Toll-like receptor signaling pathway
Serotonin HTR1 Group and FOS Pathway
DNA Damage Response (only ATM dependent)
G13 Signaling Pathway
Regulation of Actin Cytoskeleton
IL-4 Signaling Pathway
Copper homeostasis
Transcriptional activation by NRF2
IL1 and megakaryotyces in obesity
Signaling by ERBB4
Signaling by ERBB2
Fc epsilon receptor (FCERI) signaling
PI Metabolism
Interleukin-2 signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Signaling by SCF-KIT
DAP12 interactions
Gastrin-CREB signalling pathway via PKC and MAPK
TCR signaling
Signaling by PDGF
Signaling by FGFR
Signaling by EGFR
NGF signalling via TRKA from the plasma membrane
Nephrin interactions
Interleukin-3, 5 and GM-CSF signaling
GPVI-mediated activation cascade
GPCR downstream signaling
Cell surface interactions at the vascular wall
Regulation of toll-like receptor signaling pathway
AMPK SignalingWP51:Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
Allograft Rejection
AngiogenesisWP710:DNA Damage Response (only ATM dependent)
ErbB Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
ATM Signaling Pathway
Pathogenic Escherichia coli infection
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet production
TP53 Network
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP75:Toll-like receptor signaling pathway
MAPK Signaling Pathway
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Bladder Cancer
Hair Follicle Development: Induction (Part 1 of 3)
Aryl Hydrocarbon Receptor
Spinal Cord Injury
Gastric cancer network 2
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
L1CAM interactions
References
Ref 529744Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.
Ref 529744Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.

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