| Drug General Information |
| Drug ID |
D0S8BG
|
| Former ID |
DNC000603
|
| Drug Name |
EMD 55900
|
| Drug Type |
Antibody
|
| Indication |
Glioma [ICD9: 191; ICD10:C71]
|
Phase 1/2 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H22O4
|
| Canonical SMILES |
CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O
|
| InChI |
1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
|
| InChIKey |
HCZKYJDFEPMADG-TXEJJXNPSA-N
|
| CAS Number |
CAS 27686-84-6
|
| PubChem Compound ID |
|
| PubChem Substance ID |
611157, 866655, 8194602, 11111540, 11111541, 12014519, 14825338, 17405436, 43127729, 46508042, 47206636, 48395006, 49846187, 50064640, 50100292, 50106727, 50106728, 53777983, 57318179, 75686392, 90341429, 92304258, 93165579, 103298252, 104350366, 117616927, 121361759, 124750068, 124880894, 124891671, 124891672, 128043106, 134338190, 134339994, 134340295, 135030085, 136913921, 137005639, 142371896, 144203761, 160963527, 163426050, 163564831, 163693552, 163852927, 172888835, 175268494, 179150266, 184529719, 184537568
|
| Target and Pathway |
| Target(s) |
Epidermal growth factor receptor |
Target Info |
|
[2]
|
|---|
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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HIF-1 signaling pathway
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FoxO signaling pathway
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Endocytosis
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PI3K-Akt signaling pathway
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Dorso-ventral axis formation
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Focal adhesion
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Adherens junction
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Gap junction
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Oxytocin signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
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Hepatitis C
|
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Pancreatic cancer
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Endometrial cancer
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Glioma
|
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Prostate cancer
|
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Melanoma
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Bladder cancer
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Non-small cell lung cancer
|
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Central carbon metabolism in cancer
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Choline metabolism in cancer
|
|
NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling Pathway
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PANTHER Pathway
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Cadherin signaling pathway
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EGF receptor signaling pathway
|
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Pathway Interaction Database
|
LPA receptor mediated events
|
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Signaling events mediated by PTP1B
|
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Arf6 signaling events
|
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Signaling events mediated by TCPTP
|
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Thromboxane A2 receptor signaling
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SHP2 signaling
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Regulation of Telomerase
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EGF receptor (ErbB1) signaling pathway
|
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EGFR-dependent Endothelin signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Direct p53 effectors
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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E-cadherin signaling in keratinocytes
|
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ErbB receptor signaling network
|
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Internalization of ErbB1
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Stabilization and expansion of the E-cadherin adherens junction
|
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a6b1 and a6b4 Integrin signaling
|
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Syndecan-3-mediated signaling events
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Reactome
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
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SHC1 events in ERBB2 signaling
|
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PLCG1 events in ERBB2 signaling
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PIP3 activates AKT signaling
|
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GRB2 events in EGFR signaling
|
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GAB1 signalosome
|
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SHC1 events in EGFR signaling
|
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EGFR downregulation
|
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GRB2 events in ERBB2 signaling
|
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PI3K events in ERBB2 signaling
|
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EGFR Transactivation by Gastrin
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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Constitutive Signaling by EGFRvIII
|
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RAF/MAP kinase cascade
|
|
WikiPathways
|
ErbB Signaling Pathway
|
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Regulation of Actin Cytoskeleton
|
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
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Focal Adhesion
|
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Aryl Hydrocarbon Receptor Pathway
|
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Extracellular vesicle-mediated signaling in recipient cells
|
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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Bladder Cancer
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
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Signaling by ERBB4
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Signaling by ERBB2
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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PIP3 activates AKT signaling
|
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Nanoparticle-mediated activation of receptor signaling
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Aryl Hydrocarbon Receptor
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
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Gastric cancer network 2
|
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AGE/RAGE pathway
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Signaling Pathways in Glioblastoma
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Arylhydrocarbon receptor (AhR) signaling pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
|
Integrated Breast Cancer Pathway
|
|
Signaling by EGFR
|
|
L1CAM interactions
|
| References |
| REF 1 | Multiple infusions of anti-epidermal growth factor receptor (EGFR) monoclonal antibody (EMD 55,900) in patients with recurrent malignant gliomas. Eur J Cancer. 1996 Apr;32A(4):636-40. |
|---|
| REF 2 | Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer. 2002 Mar 1;94(5):1593-611. |
|---|
