| Drug General Information |
| Drug ID |
D0R6UV
|
| Former ID |
DIB018013
|
| Drug Name |
BMS-690514
|
| Synonyms |
BMS 690514; BMS690514
|
| Drug Type |
Small molecular drug
|
| Indication |
Chronic pain [ICD9: 338.2,780; ICD10:R52.1-R52.2, G89]
|
Phase 2 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H24N6O2
|
| InChI |
InChI=1S/C19H24N6O2/c1-27-15-4-2-3-14(9-15)23-19-18-13(5-8-25(18)22-12-21-19)10-24-7-6-16(20)17(26)11-24/h2-5,8-9,12,16-17,26H,6-7,10-11,20H2,1H3,(H,21,22,23)/t16-,17-/m1/s1
|
| InChIKey |
CSGQVNMSRKWUSH-IAGOWNOFSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16440760, 23508405, 24419214, 44390420, 56311932, 80481817, 124976959, 126731251, 131549339, 136368033, 136368271, 139411627, 144115737, 152088812, 152258179, 152344096, 160647015, 162011878, 162029688, 163642743, 164042004, 164178266, 174539900, 185997054, 188937099, 198989201, 223366208, 223683351, 227452231, 246525206, 251963024, 251970977, 252154827, 252215017, 252462431
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[2]
|
|---|
| Epidermal growth factor receptor |
Target Info |
Inhibitor |
[2]
|
| mRNA of HER2 |
Target Info |
Inhibitor |
[2]
|
| FL cytokine receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Ras signaling pathway
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|
Rap1 signaling pathway
|
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Cytokine-cytokine receptor interaction
|
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Endocytosis
|
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PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
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|
Proteoglycans in cancerhsa04010:MAPK signaling pathway
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ErbB signaling pathway
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Calcium signaling pathway
|
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HIF-1 signaling pathway
|
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FoxO signaling pathway
|
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Dorso-ventral axis formation
|
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Adherens junction
|
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Gap junction
|
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Regulation of actin cytoskeleton
|
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GnRH signaling pathway
|
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Estrogen signaling pathway
|
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Oxytocin signaling pathway
|
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Epithelial cell signaling in Helicobacter pylori infection
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Hepatitis C
|
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Pathways in cancer
|
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Proteoglycans in cancer
|
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MicroRNAs in cancer
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Pancreatic cancer
|
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Endometrial cancer
|
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Glioma
|
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Prostate cancer
|
|
Melanoma
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Bladder cancer
|
|
Non-small cell lung cancer
|
|
Central carbon metabolism in cancer
|
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Choline metabolism in cancerhsa04012:ErbB signaling pathway
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Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
|
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Hematopoietic cell lineage
|
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Transcriptional misregulation in cancer
|
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Acute myeloid leukemia
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathwayP00012:Cadherin signaling pathway
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EGF receptor signaling pathwayP00012:Cadherin signaling pathway
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EGF receptor signaling pathway
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Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
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Beta3 integrin cell surface interactions
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|
Signaling events mediated by TCPTP
|
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SHP2 signaling
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S1P1 pathway
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VEGF and VEGFR signaling network
|
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Integrins in angiogenesis
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Notch-mediated HES/HEY networklysophospholipid_pathway:LPA receptor mediated events
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Signaling events mediated by PTP1B
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Arf6 signaling events
|
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Thromboxane A2 receptor signaling
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Regulation of Telomerase
|
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EGF receptor (ErbB1) signaling pathway
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EGFR-dependent Endothelin signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Direct p53 effectors
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ErbB1 downstream signaling
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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E-cadherin signaling in keratinocytes
|
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ErbB receptor signaling network
|
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Internalization of ErbB1
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Stabilization and expansion of the E-cadherin adherens junction
|
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a6b1 and a6b4 Integrin signaling
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Syndecan-3-mediated signaling eventserbb4_pathway:ErbB4 signaling events
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ErbB2/ErbB3 signaling events
|
|
Validated targets of C-MYC transcriptional repression
|
|
PathWhiz Pathway
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Phosphatidylinositol Phosphate Metabolism
|
|
Reactome
|
Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
|
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Integrin cell surface interactions
|
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EPHA-mediated growth cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated cell proliferationR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
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SHC1 events in ERBB2 signaling
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PLCG1 events in ERBB2 signaling
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PIP3 activates AKT signaling
|
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GRB2 events in EGFR signaling
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GAB1 signalosome
|
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SHC1 events in EGFR signaling
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EGFR downregulation
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GRB2 events in ERBB2 signaling
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PI3K events in ERBB2 signaling
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EGFR Transactivation by Gastrin
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Constitutive Signaling by Aberrant PI3K in Cancer
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Constitutive Signaling by EGFRvIII
|
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RAF/MAP kinase cascadeR-HSA-1250196:SHC1 events in ERBB2 signaling
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Sema4D induced cell migration and growth-cone collapse
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RAF/MAP kinase cascade
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WikiPathways
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Focal Adhesion
|
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Nifedipine Activity
|
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Cardiac Progenitor Differentiation
|
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Signaling by VEGF
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AngiogenesisWP673:ErbB Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
|
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Aryl Hydrocarbon Receptor Pathway
|
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Extracellular vesicle-mediated signaling in recipient cells
|
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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Bladder Cancer
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
|
Signaling by ERBB4
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Signaling by ERBB2
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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PIP3 activates AKT signaling
|
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Nanoparticle-mediated activation of receptor signaling
|
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Aryl Hydrocarbon Receptor
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Gastric cancer network 2
|
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AGE/RAGE pathway
|
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Signaling Pathways in Glioblastoma
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Arylhydrocarbon receptor (AhR) signaling pathway
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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Integrated Breast Cancer Pathway
|
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Signaling by EGFR
|
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L1CAM interactionsWP710:DNA Damage Response (only ATM dependent)
|
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ErbB Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
| References |
| REF 1 | A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib. Cancer Res. 2007 Jul 1;67(13):6253-62. |
|---|
| REF 2 | Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. |
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