Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T11754
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Former ID |
TTDS00177
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Target Name |
Fatty-acid amide hydrolase
|
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Gene Name |
FAAH
|
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Synonyms |
Anandamide amidase; Anandamide amidohydrolase; Anandamide synthase; Arachidonylethanolamide synthase; Fatty acid amide hydrolase; Oleamidehydrolase; FAAH
|
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Target Type |
Successful
|
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Disease | Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | ||||
Anesthesia [ICD9: 338; ICD10: R20.0] | |||||
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25] | |||||
Liver disease [ICD9: 570-574; ICD10: K70-K77] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Unspecified [ICD code not available] | |||||
Function |
Degradesbioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
|
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BioChemical Class |
Carbon-nitrogen hydrolase
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Target Validation |
T11754
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UniProt ID | |||||
EC Number |
EC 3.5.1.99
|
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Sequence |
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS |
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Drugs and Mode of Action | |||||
Drug(s) | Propofol | Drug Info | Approved | Anesthesia | [525679], [540866] |
Thiopental | Drug Info | Approved | Anesthesia | [538450], [539663] | |
IW-6118 | Drug Info | Phase 2 | Inflammatory disease | [523013] | |
PF-04457845 | Drug Info | Phase 2 | Liver disease | [541799] | |
SSR411298 | Drug Info | Phase 2 | Major depressive disorder | [522544] | |
IPI-940 | Drug Info | Phase 1 | Pain | [548828] | |
Propofol | Drug Info | Investigative | Unspecified | [535758], [536166] | |
Inhibitor | (+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one | Drug Info | [529529] | ||
(+/-)-3-(pent-4-enyl)azetidin-2-one | Drug Info | [529529] | |||
(+/-)-3-allyl-1-pent-4-enoylazetidin-2-one | Drug Info | [529529] | |||
(+/-)-3-allylazetidin-2-one | Drug Info | [529529] | |||
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate | Drug Info | [529008] | |||
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate | Drug Info | [529008] | |||
(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one | Drug Info | [527476] | |||
(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one | Drug Info | [529193] | |||
(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one | Drug Info | [529193] | |||
(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one | Drug Info | [529193] | |||
(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one | Drug Info | [526085] | |||
(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one | Drug Info | [526085] | |||
1,1,1-trifluoro-3-(hexylthio)propan-2-one | Drug Info | [529157] | |||
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one | Drug Info | [529157] | |||
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one | Drug Info | [529157] | |||
1,1,1-trifluoro-3-(octylthio)propan-2-one | Drug Info | [529157] | |||
1,1,1-Trifluoro-7-phenylheptan-2-one | Drug Info | [527476] | |||
1,1,1-Trifluoro-8-phenyl-octan-2-one | Drug Info | [527476] | |||
1,1,1-Trifluoro-9-phenyl-nonan-2-one | Drug Info | [527476] | |||
1,1,1-Trifluoro-nonadecan-2-one | Drug Info | [527476] | |||
1,1,1-Trifluoro-tridecan-2-one | Drug Info | [527476] | |||
1,1,1-Trifluoro-undecan-2-one | Drug Info | [527476] | |||
1,1,1-trifluorododecan-2-one | Drug Info | [529157] | |||
1,10-(methylenedi-4,1-phenylene)bismaleimide | Drug Info | [530251] | |||
1,4-bis(malimido)xylene | Drug Info | [530251] | |||
1,8-bis-maleimidodiethyleneglycol | Drug Info | [530251] | |||
1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one | Drug Info | [529594] | |||
1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one | Drug Info | [529594] | |||
1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529594] | |||
1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one | Drug Info | [529193] | |||
1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one | Drug Info | [529193] | |||
1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one | Drug Info | [529193] | |||
1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529193] | |||
1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529193] | |||
1-(5-phenyloxazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one | Drug Info | [527476] | |||
1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one | Drug Info | [529284] | |||
1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one | Drug Info | [529327] | |||
1-(oxazol-2-yl)-7-phenylheptan-1-one | Drug Info | [529603] | |||
1-(oxazol-2-yl)octadec-9-en-1-one | Drug Info | [529594] | |||
1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one | Drug Info | [529193] | |||
1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one | Drug Info | [529193] | |||
1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one | Drug Info | [529193] | |||
1-Benzooxazol-2-yl-6-phenyl-hexan-1-one | Drug Info | [527476] | |||
1-Biphenyl-4-ylmaleimide | Drug Info | [530251] | |||
1-Biphenyl-4-ylmethylmaleimide | Drug Info | [530251] | |||
1-DODECANOL | Drug Info | [551374] | |||
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one | Drug Info | [530576] | |||
1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one | Drug Info | [527671] | |||
1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one | Drug Info | [527476] | |||
2,2-dimethyl-3-methyleneheptadecane | Drug Info | [529157] | |||
2,4-difluorophenyl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
2-(7-phenylheptanoyl)oxazole-4-carbaldehyde | Drug Info | [529603] | |||
2-(7-phenylheptanoyl)oxazole-4-carbonitrile | Drug Info | [529603] | |||
2-(7-phenylheptanoyl)oxazole-4-carboxamide | Drug Info | [529603] | |||
2-(7-phenylheptanoyl)oxazole-4-carboxylic acid | Drug Info | [529603] | |||
2-(7-phenylheptanoyl)oxazole-5-carbonitrile | Drug Info | [529603] | |||
2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | Drug Info | [529603] | |||
2-(biphenyl-4-yl)vinylboronic acid | Drug Info | [529790] | |||
2-arachidonoylglycerol | Drug Info | [529031] | |||
2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone | Drug Info | [528884] | |||
2-Cyclohexylacetic acidbiphenyl-3-yl ester | Drug Info | [529498] | |||
2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(decyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(dodecyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(heptyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(hexyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(octyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-(undecyloxy)phenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-butoxyphenylcarbamate | Drug Info | [530604] | |||
2-fluorophenyl 4-phenoxyphenylcarbamate | Drug Info | [530604] | |||
2-fluorophenylboronic acid | Drug Info | [529790] | |||
2-methoxyphenylboronic acid | Drug Info | [529790] | |||
3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate | Drug Info | [529791] | |||
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate | Drug Info | [530576] | |||
3,3-di(pent-4-enyl)azetidin-2-one | Drug Info | [529529] | |||
3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate | Drug Info | [530218] | |||
3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate | Drug Info | [530218] | |||
3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one | Drug Info | [529284] | |||
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | [529157] | |||
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | [529157] | |||
3-(decylthio)-1,1,1-trifluoropropan-2-one | Drug Info | [529157] | |||
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | [529157] | |||
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | [529157] | |||
3-(ethoxycarbonyl)phenylboronic acid | Drug Info | [529790] | |||
3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
3-(trifluoromethyl)phenylboronic acid | Drug Info | [529790] | |||
3-chlorophenyl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
3-cyanophenylboronic acid | Drug Info | [529790] | |||
3-methoxyphenylboronic acid | Drug Info | [529790] | |||
4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate | Drug Info | [529975] | |||
4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate | Drug Info | [529975] | |||
4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate | Drug Info | [529975] | |||
4-(cyclohexylmethylcarbamoyloxy)benzoic acid | Drug Info | [529791] | |||
4-(thiazol-2-yl)phenyl butylcarbamate | Drug Info | [528323] | |||
4-(trifluoromethyl)phenylboronic acid | Drug Info | [529790] | |||
4-cyanophenyl ethyl dodecylphosphonate | Drug Info | [529659] | |||
4-cyanophenylboronic acid | Drug Info | [529790] | |||
4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | [530604] | |||
4-fluorophenyl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
4-fluorophenylboronic acid | Drug Info | [529790] | |||
4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | [530604] | |||
4-methoxyphenylboronic acid | Drug Info | [529790] | |||
4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate | Drug Info | [530654] | |||
4-nitrophenylboronic acid | Drug Info | [529790] | |||
4-nonylphenylboronic acid | Drug Info | [529790] | |||
4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
6-fluoropyridin-3-ylboronic acid | Drug Info | [529790] | |||
6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one | Drug Info | [529594] | |||
7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one | Drug Info | [529594] | |||
7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one | Drug Info | [529603] | |||
7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one | Drug Info | [529594] | |||
7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one | Drug Info | [529594] | |||
7-Phenyl-1-(thiazol-2-yl)-heptan-1-one | Drug Info | [529594] | |||
8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Allylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
AM-404 | Drug Info | [529838] | |||
AR-C70484XX | Drug Info | [530576] | |||
ARACHIDONYL TRIFLUOROMETHYLKETONE | Drug Info | [530576] | |||
Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-butoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-methoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzaldehyde O-4-propoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Benzofuran-2-ylboronic acid | Drug Info | [529790] | |||
Benzo[b]thiophen-2-ylboronic acid | Drug Info | [529790] | |||
Benzylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Biphenyl-3-ylboronic acid | Drug Info | [529790] | |||
Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Biphenyl-3-ylcarbamic acid cyclohexyl ester | Drug Info | [530251] | |||
Biphenyl-4-ylboronic acid | Drug Info | [529790] | |||
BMS-1 | Drug Info | [529859] | |||
BTNP | Drug Info | [529791] | |||
Chlorphrifos oxon | Drug Info | [529440] | |||
Cyclobutylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Cyclohexyl biphenyl-4-ylcarbamate | Drug Info | [529975] | |||
Cyclohexylcarbamic acidbiphenyl-3-yl ester | Drug Info | [529498] | |||
Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone | Drug Info | [528884] | |||
Cyclopentylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Dodecane-1-sulfonyl fluoride | Drug Info | [529659] | |||
Ethyl octylfluorophosphonate | Drug Info | [529440] | |||
Fatty acid amide hydrolase inhibitors | Drug Info | [543418] | |||
Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
HTS-00798 | Drug Info | [528323] | |||
Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
IPI-940 | Drug Info | [543418] | |||
Isopropyl 4-nitrophenyl dodecylphosphonate | Drug Info | [529659] | |||
Isopropyl dodecylfluorophosphonate | Drug Info | [529440] | |||
Isopropylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
JNJ-1661010 | Drug Info | [529638] | |||
LY-2183240 | Drug Info | [529791] | |||
LY-2318912 | Drug Info | [528802] | |||
Methoxy arachidonyl fluorophosphonate | Drug Info | [551393] | |||
Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate | Drug Info | [529603] | |||
Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate | Drug Info | [529594] | |||
Methyl icosylphosphonofluoridate | Drug Info | [529659] | |||
Methylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
N-(2-hydroxyethyl)linoleoylamide | Drug Info | [529848] | |||
N-(2-iodethyl)arachidonylamide | Drug Info | [529848] | |||
N-(2-iodoethyl)linoleoylamide | Drug Info | [529848] | |||
N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide | Drug Info | [529838] | |||
N-arachidonylmaleimide | Drug Info | [530251] | |||
N-Butylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
N-Hexylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
N-Octylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Naphthalen-2-yl cyclohexylcarbamate | Drug Info | [529791] | |||
NICARBAZIN | Drug Info | [530469] | |||
Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Octane-1-sulfonyl fluoride | Drug Info | [529659] | |||
OL-135 | Drug Info | [530527] | |||
OL-92 | Drug Info | [529859] | |||
Org-231295 | Drug Info | [543418] | |||
PARAOXON | Drug Info | [529440] | |||
PF-04457845 | Drug Info | [531512] | |||
PF3845 | Drug Info | [530091] | |||
PF750 | Drug Info | [529113] | |||
Phenethylboronic acid | Drug Info | [529790] | |||
Phenethylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
PHENMEDIPHAM | Drug Info | [530469] | |||
Phenyl 1-(4-butoxyphenyl)propylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(decyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(dodecyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(heptyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(hexyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(octyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl 4-(undecyloxy)phenylcarbamate | Drug Info | [530604] | |||
Phenyl Boronic acid | Drug Info | [529790] | |||
Phenyl-1,4-bismaleimide | Drug Info | [530251] | |||
Phenylcarbamic Acid Biphenyl-3-yl Ester | Drug Info | [529498] | |||
Propan-2-one O-3-butoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-butoxybenzylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-butoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-ethoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Propan-2-one O-4-propoxyphenylcarbamoyl oxime | Drug Info | [530604] | |||
Propofol | Drug Info | [535758], [536166] | |||
Pyridin-3-yl 4-butoxybenzylcarbamate | Drug Info | [530604] | |||
SSR411298 | Drug Info | [549823] | |||
Thiopental | Drug Info | [535758] | |||
VER-156084 | Drug Info | [530200] | |||
Modulator | IW-6118 | Drug Info | [544183] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Anandamide degradation | ||||
KEGG Pathway | Retrograde endocannabinoid signaling | ||||
PANTHER Pathway | Anandamide degradation | ||||
References | |||||
Ref 522544 | ClinicalTrials.gov (NCT00822744) An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patients. U.S. National Institutes of Health. | ||||
Ref 523013 | ClinicalTrials.gov (NCT01107236) Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar Extraction. U.S. National Institutes of Health. | ||||
Ref 525679 | Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000 Feb;7(2):249-71. | ||||
Ref 535758 | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13. | ||||
Ref 538450 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011679. | ||||
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Ref 543418 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400). |
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