Drug General Information
Drug ID
D0W6PT
Former ID
DNC014028
Drug Name
Chlorphrifos oxon
Synonyms
Diethyl 3,5,6-trichloropyridin-2-yl phosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529659]
Structure
Download
2D MOL

3D MOL

Formula
C9H11Cl3NO4P
Canonical SMILES
CCOP(=O)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl
InChI
1S/C9H11Cl3NO4P/c1-3-15-18(14,16-4-2)17-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
InChIKey
OTMOUPHCTWPNSL-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [529440]
Fatty-acid amide hydrolase Target Info Inhibitor [529440]
Cannabinoid receptor 1 Target Info Inhibitor [529659]
BioCyc Pathway Anandamide degradation
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapsehsa04723:Retrograde endocannabinoid signalinghsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathwayP05728:Anandamide degradationP05730:Endogenous cannabinoid signaling
Pathway Interaction Database ATF-2 transcription factor networkncadherinpathway:N-cadherin signaling events
PathWhiz Pathway Phospholipid Biosynthesis
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer PathwayWP455:GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 529440Nat Chem Biol. 2008 Jun;4(6):373-8. Epub 2008 Apr 27.Activation of the endocannabinoid system by organophosphorus nerve agents.
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.

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