Drug Information

Drug General Information
Drug ID
D00MYT
Former ID
DAP000661
Drug Name
Thiopental
Synonyms
Intraval; Penthiobarbital; Pentothiobarbital; Thiomebumal; Thionembutal; Thiopentobarbital; Thiopentobarbitone; Thiopentone; Thiothal; Tiopentale; Trapanal; Thiopental [BAN]; Thiopental solution; Thiopentobarbituric acid; Tiopentale [Italian]; Sodium Pentothal (TN); Thiopental (TN); Thiopentone sodium (TN); Trapanal (TN); (+-)-Thiopental; (+/-)-THIOPENTAL; (+/-)-Thiopental solution; 2-Thio-5-ethyl-5-sec-pentylbarbituric acid; 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-(9CI); 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [538450], [539663]
Therapeutic Class
Hypnotics and Sedatives
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C11H18N2O2S
InChI
InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChIKey
IUJDSEJGGMCXSG-UHFFFAOYSA-N
CAS Number
CAS 76-75-5
PubChem Compound ID
3000715
PubChem Substance ID
9724, 607917, 4785343, 6467449, 7980775, 10036288, 10535341, 11336168, 11361407, 11364686, 11367248, 11369810, 11372900, 11374149, 11377973, 11462379, 11485951, 11489814, 11491596, 11492390, 11495600, 14847511, 24899925, 24899928, 29215503, 34666697, 46504621, 47662379, 48259334, 48259335, 48416612, 49874351, 50521000, 57410125, 57654650, 81065587, 85307774, 85787415, 92714660, 103165674, 103954037, 104226110, 111610413, 117425383, 126623959, 126670641, 128221740, 134337950, 134971833, 135651257
SuperDrug ATC ID
N01AF03; N05CA19
SuperDrug CAS ID
cas=000076755
Target and Pathway
Target(s) Fatty-acid amide hydrolase Target Info Inhibitor [535758]
BioCyc Pathway Anandamide degradation
KEGG Pathway Retrograde endocannabinoid signaling
PANTHER Pathway Anandamide degradation
References
Ref 538450FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011679.
Ref 539663(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2579).
Ref 535758The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.

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