Drug General Information
Drug ID	D0EJ9B
Former ID	DNC005114
Drug Name	Phenyl Boronic acid
Synonyms	Phenylboronic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530358]
Structure		Download 2D MOL 3D MOL
Formula	C6H7BO2
Canonical SMILES	B(C1=CC=CC=C1)(O)O
InChI	1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H
InChIKey	HXITXNWTGFUOAU-UHFFFAOYSA-N
PubChem Compound ID	66827
Target and Pathway
Target(s)	D-alanyl-D-alanine carboxypeptidase	Target Info	Inhibitor	[530358]
	Carbonic anhydrase II	Target Info	Inhibitor	[527231]
	Carbonic anhydrase IV	Target Info	Inhibitor	[529905]
	Carbonic anhydrase	Target Info	Inhibitor	[528141]
	Fatty-acid amide hydrolase	Target Info	Inhibitor	[529790]
	Carbonic anhydrase I	Target Info	Inhibitor	[527231]
BioCyc Pathway	Anandamide degradation
KEGG Pathway	Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamationhsa04723:Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolism
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Anandamide degradation
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530358	J Med Chem. 2009 Oct 8;52(19):6097-106.Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
Ref 527231	Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
Ref 528141	Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Ref 529790	J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529905	Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. Epub 2008 Dec 25.Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Ref 530358	J Med Chem. 2009 Oct 8;52(19):6097-106.Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

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