Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0EJ9B
|
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| Former ID |
DNC005114
|
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| Drug Name |
Phenyl Boronic acid
|
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| Synonyms |
Phenylboronic acid
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C6H7BO2
|
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| Canonical SMILES |
B(C1=CC=CC=C1)(O)O
|
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| InChI |
1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H
|
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| InChIKey |
HXITXNWTGFUOAU-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | D-alanyl-D-alanine carboxypeptidase | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase II | Target Info | Inhibitor | [2] | ||
| Carbonic anhydrase IV | Target Info | Inhibitor | [3] | ||
| Carbonic anhydrase | Target Info | Inhibitor | [4] | ||
| Fatty-acid amide hydrolase | Target Info | Inhibitor | [5] | ||
| Carbonic anhydrase I | Target Info | Inhibitor | [2] | ||
| BioCyc Pathway | Anandamide degradation | ||||
| KEGG Pathway | Nitrogen metabolism | ||||
| Proximal tubule bicarbonate reclamation | |||||
| Collecting duct acid secretion | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Bile secretionhsa00910:Nitrogen metabolism | |||||
| Proximal tubule bicarbonate reclamationhsa04723:Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolism | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| PANTHER Pathway | Anandamide degradation | ||||
| Pathway Interaction Database | C-MYB transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| References | |||||
| REF 1 | J Med Chem. 2009 Oct 8;52(19):6097-106.Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. | ||||
| REF 2 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
| REF 3 | Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. Epub 2008 Dec 25.Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. | ||||
| REF 4 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. | ||||
| REF 5 | J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | ||||
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