Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T25309 Target Info
Target Name Signal transduction protein CBL (CBL)
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; CBL2; C-Cbl
Target Type Literature-reported Target
Gene Name CBL
Biochemical Class Acyltransferase
UniProt ID
CBL_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Myosin-9 (MYH9) Interacting Protein Interacting Protein Info
UniProt ID
MYH9_HUMAN 
Synonyms BDPLT6; DFNA17; EPSTS; FTNS; MHA; NMHC.II.A; NMMHC.IIA; NMMHCA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [2]
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Actins [+] 1 Actins +
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name NEDD8-conjugating enzyme Ubc12 (UBE2M) Interacting Protein Interacting Protein Info
UniProt ID
UBC12_HUMAN 
Synonyms UBC.RS2; UBC12; hUbc12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Adapter proteins [+] 7 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [11]
10 Affinity Capture-Western [12]
11 Affinity Capture-Western [13]
12 Affinity Capture-Western [14]
13 Affinity Capture-Western [15]
14 Affinity Capture-Western [16]
15 Affinity Capture-Western [17]
16 Affinity Capture-Western [18]
17 Affinity Capture-Western [19]
18 Affinity Capture-Western [20]
19 Affinity Capture-Western [21]
20 Affinity Capture-Western [22]
Interacting Protein Name SH3 domain-containing kinase-binding protein 1 (SH3KBP1) Interacting Protein Interacting Protein Info
UniProt ID
SH3K1_HUMAN 
Synonyms CD2BP3; CIN85; GIG10; HSB.1; HSB1; MIG18
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [23]
5 Affinity Capture-Western [24]
6 Affinity Capture-Western [25]
7 Affinity Capture-Western [26]
8 Affinity Capture-Western [27]
9 Affinity Capture-Western [28]
10 Affinity Capture-Western [29]
11 Affinity Capture-Western [30]
12 Affinity Capture-Western [31]
13 Affinity Capture-Western [32]
14 Affinity Capture-Western [33]
15 Affinity Capture-Western [34]
16 Affinity Capture-Western [35]
17 Affinity Capture-Western [36]
18 Affinity Capture-Western [37]
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [39]
5 Affinity Capture-Western [40]
6 Reconstituted Complex [40]
Interacting Protein Name Src-like-adapter (SLA) Interacting Protein Interacting Protein Info
UniProt ID
SLAP1_HUMAN 
Synonyms SLA1; SLAP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [42]
3 Reconstituted Complex [43]
Interacting Protein Name Sorbin and SH3 domain-containing protein 2 (SORBS2) Interacting Protein Interacting Protein Info
UniProt ID
SRBS2_HUMAN 
Synonyms ARGBP2; PRO0618
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Affinity Capture-Western [45]
3 Yeast two hybrid [45]
Interacting Protein Name SH2B adapter protein 2 (SH2B2) Interacting Protein Interacting Protein Info
UniProt ID
SH2B2_HUMAN 
Synonyms APS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Co-crystal Structure [47]
Interacting Protein Name Src-like-adapter 2 (SLA2) Interacting Protein Interacting Protein Info
UniProt ID
SLAP2_HUMAN 
Synonyms C20orf156; MARS; SLAP.2; SLAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Reconstituted Complex [49]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Affinity Capture-Western [39]
3 Affinity Capture-Western [51]
4 Co-localization [52]
5 Far Western [53]
6 Fluorescence Resonance Energy Transfer [54]
Interacting Protein Name Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) Interacting Protein Interacting Protein Info
UniProt ID
SHIP2_HUMAN 
Synonyms OPSMD; SHIP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [55]
3 Affinity Capture-Western [56]
Glycosylases [+] 1 Glycosylases +
Interacting Target Name Cyclic ADP-ribose hydrolase 1 (CD38) Successful Target Interacting Protein Info
UniProt ID
CD38_HUMAN 
Synonyms T10; Cyclic ADPribose hydrolase 1; cADPr hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; ADPribosyl cyclase 1; ADPRC 1; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Fluorescence Resonance Energy Transfer [58]
3 Fluorescence Resonance Energy Transfer [57]
Kinases [+] 23 Kinases +
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [23]
3 Affinity Capture-Western [59]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [2]
6 Affinity Capture-Western [60]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [15]
9 Affinity Capture-Western [16]
10 Affinity Capture-Western [17]
11 Affinity Capture-Western [21]
12 Affinity Capture-Western [61]
13 Affinity Capture-Western [62]
14 Affinity Capture-Western [63]
15 Affinity Capture-Western [64]
16 Affinity Capture-Western [65]
17 Affinity Capture-Western [66]
18 Affinity Capture-Western [67]
19 Affinity Capture-Western [68]
20 Affinity Capture-Western [69]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Affinity Capture-Western [71]
3 Affinity Capture-Western [72]
4 Affinity Capture-Western [73]
5 Affinity Capture-Western [74]
6 Affinity Capture-Western [75]
7 Affinity Capture-Western [76]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [77]
10 Affinity Capture-Western [78]
11 Affinity Capture-Western [79]
12 Affinity Capture-Western [14]
13 Affinity Capture-Western [15]
14 Affinity Capture-Western [80]
15 Affinity Capture-Western [81]
16 Affinity Capture-Western [82]
17 Affinity Capture-Western [83]
18 Affinity Capture-Western [84]
19 Biochemical Activity [85]
20 Biochemical Activity [86]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [45]
3 Affinity Capture-Western [87]
4 Affinity Capture-Western [88]
5 Affinity Capture-Western [89]
6 Affinity Capture-Western [90]
7 Affinity Capture-Western [91]
8 Biochemical Activity [92]
9 Far Western [87]
10 Far Western [89]
11 Reconstituted Complex [88]
12 Reconstituted Complex [93]
Interacting Target Name Tyrosine-protein kinase SYK (SYK) Successful Target Interacting Protein Info
UniProt ID
KSYK_HUMAN 
Synonyms Spleen tyrosine kinase; p72-Syk
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [68]
4 Affinity Capture-Western [95]
5 Affinity Capture-Western [96]
6 Affinity Capture-Western [97]
7 Affinity Capture-Western [98]
8 Affinity Capture-Western [99]
9 Biochemical Activity [97]
10 Reconstituted Complex [94]
11 Reconstituted Complex [99]
12 Reconstituted Complex [100]
Interacting Target Name Tyrosine-protein kinase ZAP-70 (ZAP-70) Patented-recorded Target Interacting Protein Info
UniProt ID
ZAP70_HUMAN 
Synonyms Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [101]
2 Affinity Capture-Western [39]
3 Affinity Capture-Western [102]
4 Affinity Capture-Western [103]
5 Affinity Capture-Western [104]
6 Co-crystal Structure [105]
7 Co-crystal Structure [86]
8 Co-crystal Structure [106]
9 Reconstituted Complex [101]
10 Reconstituted Complex [86]
Interacting Target Name Proto-oncogene c-Met (MET) Successful Target Interacting Protein Info
UniProt ID
MET_HUMAN 
Synonyms Tyrosine-protein kinase Met; SF receptor; Scatter factor receptor; Met proto-oncogene tyrosine kinase; HGF-SF receptor; HGF/SF receptor; HGF receptor; Hepatocyte growth factor receptor; C-Met receptor tyrosine kinase; C-met
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Affinity Capture-Western [108]
3 Biochemical Activity [26]
4 Co-crystal Structure [109]
5 Co-localization [52]
6 Far Western [108]
7 Reconstituted Complex [108]
8 Reconstituted Complex [109]
9 Reconstituted Complex [110]
Interacting Target Name Fyn tyrosine protein kinase (FYN) Successful Target Interacting Protein Info
UniProt ID
FYN_HUMAN 
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [111]
2 Affinity Capture-Western [112]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [17]
5 Affinity Capture-Western [113]
6 Reconstituted Complex [112]
7 Yeast two hybrid [114]
Interacting Target Name Macrophage colony-stimulating factor 1 receptor (CSF1R) Successful Target Interacting Protein Info
UniProt ID
CSF1R_HUMAN 
Synonyms Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1-R; CSF-1R; CSF-1 receptor; CD115
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [115]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [116]
4 Reconstituted Complex [117]
5 Reconstituted Complex [115]
6 Yeast two hybrid [117]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [118]
2 Affinity Capture-Western [88]
3 Affinity Capture-Western [72]
4 Affinity Capture-Western [65]
5 Reconstituted Complex [119]
Interacting Target Name Tyrosine-protein kinase BTK (ATK) Successful Target Interacting Protein Info
UniProt ID
BTK_HUMAN 
Synonyms Bruton's tyrosine kinase; Bruton tyrosine kinase; BPK; B-cell progenitor kinase; B cell progenitor kinase; AGMX1; Agammaglobulinemia tyrosine kinase; Agammaglobulinaemia tyrosine kinase
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [120]
2 Co-crystal Structure [121]
3 Protein-peptide [122]
4 Reconstituted Complex [123]
Interacting Target Name Hematopoietic cell kinase (HCK) Patented-recorded Target Interacting Protein Info
UniProt ID
HCK_HUMAN 
Synonyms Tyrosine-protein kinase HCK; p61Hck; p59-HCK/p60-HCK; p59Hck; Hemopoietic cell kinase
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Affinity Capture-Western [125]
3 Far Western [125]
4 Protein-peptide [126]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [23]
3 Affinity Capture-Western [127]
4 Affinity Capture-Western [128]
Interacting Target Name Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target Interacting Protein Info
UniProt ID
PGFRA_HUMAN 
Synonyms RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGF-R-alpha; PDGFR-alpha; PDGFR-2; PDGFR2; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [129]
2 Affinity Capture-Western [130]
3 Reconstituted Complex [130]
Interacting Target Name PI3-kinase alpha (PIK3CA) Successful Target Interacting Protein Info
UniProt ID
PK3CA_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; PtdIns3kinase subunit p110alpha; PtdIns-3-kinase subunit alpha; PtdIns3kinase subunit alpha; PI3-kinase subunit alpha; PI3kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; p110alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [131]
3 Affinity Capture-Western [60]
Interacting Target Name Ephrin type-B receptor 1 (EPHB1) Literature-reported Target Interacting Protein Info
UniProt ID
EPHB1_HUMAN 
Synonyms Tyrosine-protein kinase receptor EPH-2; Neuronally-expressed EPH-related tyrosine kinase; hEK6; EPHT2; EPH-like kinase 6; EPH tyrosine kinase 2; ELK; EK6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [132]
2 Affinity Capture-Western [133]
3 Reconstituted Complex [132]
Interacting Protein Name Breakpoint cluster region protein (BCR) Interacting Protein Interacting Protein Info
UniProt ID
BCR_HUMAN 
Synonyms ALL; BCR1; CML; D22S11; D22S662; PHL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [92]
3 Reconstituted Complex [93]
Interacting Target Name LCK tyrosine protein kinase (LCK) Successful Target Interacting Protein Info
UniProt ID
LCK_HUMAN 
Synonyms Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [134]
2 Reconstituted Complex [135]
Interacting Target Name Tropomyosin-related kinase A (TrkA) Successful Target Interacting Protein Info
UniProt ID
NTRK1_HUMAN 
Synonyms Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [136]
2 Affinity Capture-Western [137]
Interacting Target Name Proto-oncogene c-Ret (RET) Successful Target Interacting Protein Info
UniProt ID
RET_HUMAN 
Synonyms RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; PTC; Proto-oncogene tyrosine-protein kinase receptor Ret; C-ret; CDHR16; CDHF12; Cadherin family member 12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [138]
2 Far Western [139]
Interacting Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target Interacting Protein Info
UniProt ID
VGFR2_HUMAN 
Synonyms VEGFR-2; VEGFR2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; FLK-1; FLK1; Fetal liver kinase 1; CD309
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [140]
2 Reconstituted Complex [50]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Co-localization [72]
Interacting Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target Interacting Protein Info
UniProt ID
LYN_HUMAN 
Synonyms V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [142]
2 Reconstituted Complex [119]
Interacting Target Name Tyrosine-protein kinase CSK (CSK) Patented-recorded Target Interacting Protein Info
UniProt ID
CSK_HUMAN 
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [143]
Proteins 14-3-3 [+] 2 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [60]
3 Affinity Capture-Western [144]
4 Reconstituted Complex [144]
5 Yeast two hybrid [144]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [145]
3 Affinity Capture-Western [62]
4 Affinity Capture-Western [146]
Ubiquitin related proteins [+] 5 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [147]
2 Biochemical Activity [148]
3 Biochemical Activity [75]
4 Biochemical Activity [149]
5 Co-crystal Structure [150]
6 Co-crystal Structure [151]
7 Reconstituted Complex [150]
8 Reconstituted Complex [147]
9 Reconstituted Complex [152]
10 Reconstituted Complex [153]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 9 Experimental Evidences +
1 Co-crystal Structure [86]
2 Reconstituted Complex [92]
3 Reconstituted Complex [154]
4 Reconstituted Complex [86]
5 Reconstituted Complex [75]
6 Reconstituted Complex [155]
7 Reconstituted Complex [156]
8 Reconstituted Complex [153]
9 Reconstituted Complex [157]
Interacting Protein Name Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) Interacting Protein Interacting Protein Info
UniProt ID
UBS3A_HUMAN 
Synonyms CLIP4; STS.2; TULA; TULA.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [158]
3 Affinity Capture-Western [23]
4 Affinity Capture-Western [159]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) Interacting Protein Interacting Protein Info
UniProt ID
UB2L3_HUMAN 
Synonyms E2.F1; L.UBC; UBCH7; UbcM4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [160]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [161]
Interacting Target Name E3 ubiquitin protein ligase CBLB (CBLB) Literature-reported Target Interacting Protein Info
UniProt ID
CBLB_HUMAN 
Synonyms Signal transduction protein CBL-B; Signal transduction protein CBLB; SH3-binding protein CBL-B; SH3binding protein CBLB; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitinprotein ligase CBLB; Casitas B-lineage lymphoma proto-oncogene b; Casitas Blineage lymphoma protooncogene b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [162]
Other proteins [+] 8 Other proteins +
Interacting Protein Name Crk-like protein (CRKL) Interacting Protein Interacting Protein Info
UniProt ID
CRKL_HUMAN 
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [163]
3 Affinity Capture-Western [164]
4 Affinity Capture-Western [165]
5 Affinity Capture-Western [166]
6 Affinity Capture-Western [127]
7 Affinity Capture-Western [142]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [11]
10 Affinity Capture-Western [7]
11 Affinity Capture-Western [39]
12 Affinity Capture-Western [167]
13 Affinity Capture-Western [60]
14 Far Western [89]
15 Far Western [168]
16 Reconstituted Complex [169]
17 Yeast two hybrid [114]
Interacting Protein Name Protein sprouty homolog 2 (SPRY2) Interacting Protein Interacting Protein Info
UniProt ID
SPY2_HUMAN 
Synonyms hSPRY2
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [170]
2 Affinity Capture-Western [160]
3 Affinity Capture-Western [171]
4 Affinity Capture-Western [172]
5 Affinity Capture-Western [173]
6 Affinity Capture-Western [174]
7 Affinity Capture-Western [175]
8 Affinity Capture-Western [176]
9 Affinity Capture-Western [177]
10 Reconstituted Complex [178]
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [179]
3 Affinity Capture-Western [164]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [180]
6 Affinity Capture-Western [165]
7 Affinity Capture-Western [181]
8 Affinity Capture-Western [182]
9 Protein-peptide [126]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [183]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [20]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [184]
Interacting Protein Name Proto-oncogene vav (VAV1) Interacting Protein Interacting Protein Info
UniProt ID
VAV_HUMAN 
Synonyms VAV
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [185]
2 Affinity Capture-Western [164]
3 Affinity Capture-Western [58]
4 Affinity Capture-Western [181]
5 Affinity Capture-Western [95]
6 Far Western [185]
7 Reconstituted Complex [185]
Interacting Protein Name CD2-associated protein (CD2AP) Interacting Protein Interacting Protein Info
UniProt ID
CD2AP_HUMAN 
Synonyms CMS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [44]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [186]
2 Affinity Capture-Western [187]
3 Biochemical Activity [186]
Interacting Protein Name Tubulin beta chain (TUBB) Interacting Protein Interacting Protein Info
UniProt ID
TBB5_HUMAN 
Synonyms CDCBM6; M40; OK/SW.cl.56; TUBB1; TUBB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [188]
References  Top
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REF 136 Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Sci Signal. 2015 Apr 28;8(374):ra40.
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REF 138 PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting. Cancer Res. 2003 May 1;63(9):2234-43.
REF 139 Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization. J Cell Sci. 2017 Oct 1;130(19):3282-3296.
REF 140 Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-B Pathway Via Actin and Tyrosine Kinases. Cell Mol Bioeng. 2009 Sep 1;2(3):341-350.
REF 141 Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. J Immunol. 2007 Aug 15;179(4):2397-407.
REF 142 c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J Immunol. 2002 Oct 1;169(7):3793-800.
REF 143 Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001 Jan 8;152(1):181-95.
REF 144 A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Biochem Biophys Res Commun. 1997 Nov 7;240(1):46-50.
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REF 146 Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils. Biochem Biophys Res Commun. 2004 May 14;317(4):1000-5.
REF 147 Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene. 2004 Sep 16;23(42):7104-15.
REF 148 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55.
REF 149 Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods. 2017 May;14(5):504-512.
REF 150 Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell. 2007 Aug 3;27(3):474-85.
REF 151 Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3. Nat Struct Mol Biol. 2013 Aug;20(8):982-986.
REF 152 TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF in TLR9 signaling. Mol Immunol. 2015 Dec;68(2 Pt C):699-705.
REF 153 Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation. BMC Biol. 2016 Sep 8;14:76.
REF 154 Small molecules that bind the Mdm2 RING stabilize and activate p53. Carcinogenesis. 2012 Apr;33(4):791-8.
REF 155 Methods to Investigate EGFR Ubiquitination. Methods Mol Biol. 2017;1652:81-100.
REF 156 Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis. Blood. 2013 Dec 5;122(24):3964-72.
REF 157 Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res. 2008 Jul 15;68(14):5669-77.
REF 158 Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol. 2006 Feb;8(2):163-9.
REF 159 Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem. 2004 Jul 30;279(31):32786-95.
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