Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Tyrosine-protein kinase CSK (CSK) | Patented-recorded | Target Info | ||
UniProt ID | CSK_HUMAN | ||||
Gene Name | CSK | ||||
Gene ID | 1445 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [2] | ||
Interacting Literature-reported Target(s) | Signal transduction protein CBL (CBL) | Target Info | PPI Info | [3] | |
Caveolin 1 (CAV1) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686. | ||||
REF 3 | Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001 Jan 8;152(1):181-95. | ||||
REF 4 | SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. PLoS One. 2014 Mar 14;9(3):e91582. |
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