Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Breakpoint cluster region protein (BCR) | ||||
UniProt ID | BCR_HUMAN | ||||
Gene Name | BCR | ||||
Gene ID | 613 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | Tyrosine-protein kinase ABL1 (ABL) | Target Info | PPI Info | [1] | |
Interacting Patented-recorded Target(s) | Protein-tyrosine phosphatase SHP-1 (PTPN6) | Target Info | PPI Info | [2] | |
Interacting Literature-reported Target(s) | Proto-oncogene c-Crk (c-Crk) | Target Info | PPI Info | [3] | |
Proto-oncogene c-Fes (FES) | Target Info | PPI Info | [4] | ||
Signal transduction protein CBL (CBL) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 1991 Jul 12;66(1):161-71. | ||||
REF 2 | Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44. | ||||
REF 3 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
REF 4 | The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl. Cancer Res. 2000 Feb 15;60(4):1097-103. | ||||
REF 5 | Bag1 directly routes immature BCR-ABL for proteasomal degradation. Blood. 2010 Nov 4;116(18):3582-92. |
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