Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T27297 Target Info
Target Name Proto-oncogene c-Crk (c-Crk)
Synonyms P38; Adapter molecule crk
Target Type Literature-reported Target
Gene Name CRK
UniProt ID
CRK_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [9]
10 Affinity Capture-Western [10]
11 Affinity Capture-Western [11]
12 Reconstituted Complex [2]
13 Reconstituted Complex [12]
14 Reconstituted Complex [13]
15 Yeast two hybrid [14]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [15]
4 Far Western [16]
5 Reconstituted Complex [17]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
Kinases [+] 12 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [19]
2 Affinity Capture-Western [20]
3 Biochemical Activity [21]
4 Protein-Fragment Complementation Assay [19]
5 Protein-peptide [22]
6 Yeast two hybrid [23]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [24]
3 Biochemical Activity [25]
4 Reconstituted Complex [26]
5 Yeast two hybrid [27]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [28]
3 Affinity Capture-Western [4]
4 Co-localization [29]
5 Yeast two hybrid [14]
Interacting Target Name Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target Interacting Protein Info
UniProt ID
PGFRA_HUMAN 
Synonyms RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGF-R-alpha; PDGFR-alpha; PDGFR-2; PDGFR2; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Co-localization [29]
3 Reconstituted Complex [30]
Interacting Target Name MEK kinase kinase 1 (MAP4K1) Clinical trial Target Interacting Protein Info
UniProt ID
M4K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase kinase 1; MEKKK 1; MAPK/ERK kinase kinase kinase 1; HPK1; Hematopoietic progenitor kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [32]
3 Reconstituted Complex [33]
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-localization [29]
Interacting Target Name Proto-oncogene c-Ret (RET) Successful Target Interacting Protein Info
UniProt ID
RET_HUMAN 
Synonyms RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; PTC; Proto-oncogene tyrosine-protein kinase receptor Ret; C-ret; CDHR16; CDHF12; Cadherin family member 12
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [29]
2 Reconstituted Complex [34]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [35]
2 Yeast two hybrid [14]
Interacting Target Name Tyrosine-protein kinase ABL2 (ABL2) Literature-reported Target Interacting Protein Info
UniProt ID
ABL2_HUMAN 
Synonyms Tyrosine-protein kinase ARG; ARG; ABLL; Abelson-related gene protein; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [14]
Interacting Protein Name Breakpoint cluster region protein (BCR) Interacting Protein Interacting Protein Info
UniProt ID
BCR_HUMAN 
Synonyms ALL; BCR1; CML; D22S11; D22S662; PHL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [3]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) Interacting Protein Interacting Protein Info
UniProt ID
P55G_HUMAN 
Synonyms p55; p55.GAMMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [14]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [14]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name E3 ubiquitin protein ligase CBLB (CBLB) Literature-reported Target Interacting Protein Info
UniProt ID
CBLB_HUMAN 
Synonyms Signal transduction protein CBL-B; Signal transduction protein CBLB; SH3-binding protein CBL-B; SH3binding protein CBLB; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitinprotein ligase CBLB; Casitas B-lineage lymphoma proto-oncogene b; Casitas Blineage lymphoma protooncogene b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [14]
Other proteins [+] 11 Other proteins +
Interacting Protein Name Breast cancer anti-estrogen resistance protein 1 (BCAR1) Interacting Protein Interacting Protein Info
UniProt ID
BCAR1_HUMAN 
Synonyms CAS; CAS1; CASS1; CRKAS; P130Cas
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [36]
3 Affinity Capture-Western [37]
4 Affinity Capture-Western [38]
5 Affinity Capture-Western [39]
6 Affinity Capture-Western [40]
7 Affinity Capture-Western [41]
8 Affinity Capture-Western [42]
9 Affinity Capture-Western [43]
10 Affinity Capture-Western [44]
11 Affinity Capture-Western [18]
12 Reconstituted Complex [35]
Interacting Protein Name Dedicator of cytokinesis protein 1 (DOCK1) Interacting Protein Interacting Protein Info
UniProt ID
DOCK1_HUMAN 
Synonyms DOCK180; ced5
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Affinity Capture-Western [37]
3 Affinity Capture-Western [41]
4 Affinity Capture-Western [45]
5 Affinity Capture-Western [46]
6 Co-fractionation [46]
7 Reconstituted Complex [36]
8 Reconstituted Complex [16]
Interacting Protein Name Rap guanine nucleotide exchange factor 1 (RAPGEF1) Interacting Protein Interacting Protein Info
UniProt ID
RPGF1_HUMAN 
Synonyms C3G; GRF2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [47]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [48]
6 Reconstituted Complex [48]
Interacting Protein Name Son of sevenless homolog 1 (SOS1) Interacting Protein Interacting Protein Info
UniProt ID
SOS1_HUMAN 
Synonyms GF1; GGF1; GINGF; HGF; NS4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [3]
4 Co-localization [29]
5 Reconstituted Complex [15]
Interacting Target Name Enhancer of filamentation 1 (NEDD9) Literature-reported Target Interacting Protein Info
UniProt ID
CASL_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-12; p105; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; hEF1; CRK-associated substrate-related protein; CASS2; CAS-L; CasL; Cas scaffolding protein family member 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Affinity Capture-Western [50]
3 Reconstituted Complex [49]
Interacting Target Name Suppressor of cytokine signaling 1 (SOCS1) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS1_HUMAN 
Synonyms TIP-3; TIP3; Tec-interacting protein 3; STAT-induced STAT inhibitor 1; STAT induced STAT inhibitor 1; SSI-1; SSI1; SOCS-1; JAK-binding protein; JAB
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [51]
2 Yeast two hybrid [14]
Interacting Protein Name ARF GTPase-activating protein 1 (ASAP1) Interacting Protein Interacting Protein Info
UniProt ID
ASAP1_HUMAN 
Synonyms AMAP1; CENTB4; DDEF1; PAG2; PAP; ZG14P
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [52]
Interacting Protein Name Development and differentiation-enhancing factor-like 1 (ASAP3) Interacting Protein Interacting Protein Info
UniProt ID
ASAP3_HUMAN 
Synonyms ACAP4; CENTB6; DDEFL1; UPLC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [53]
Interacting Protein Name Insulin receptor substrate 4 (IRS4) Interacting Protein Interacting Protein Info
UniProt ID
IRS4_HUMAN 
Synonyms IRS.4; PY160
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Reconstituted Complex [55]
Interacting Protein Name Paxillin (PXN) Interacting Protein Interacting Protein Info
UniProt ID
PAXI_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Reconstituted Complex [35]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
References  Top
REF 1 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 2 Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J Immunol. 1996 Jul 1;157(1):110-6.
REF 3 B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. J Biol Chem. 1996 Dec 13;271(50):32306-14.
REF 4 The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. Oncogene. 2000 Aug 17;19(35):4058-65.
REF 5 Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem. 1996 Jun 14;271(24):14554-9.
REF 6 Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells. J Biol Chem. 1998 Feb 13;273(7):3986-93.
REF 7 Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. Blood. 1997 May 1;89(9):3166-74.
REF 8 CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2. Oncogene. 1997 May 15;14(19):2331-8.
REF 9 Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. J Biol Chem. 1996 Mar 15;271(11):6159-63.
REF 10 Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Oncogene. 1997 Dec 11;15(24):2909-19.
REF 11 The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol Cell Biol. 1996 Jan;16(1):45-52.
REF 12 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 5;271(14):8435-42.
REF 13 Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation. Mol Immunol. 2002 Jan;38(8):587-96.
REF 14 Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol. 2015 Mar 26;11(3):794.
REF 15 Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. J Biol Chem. 1996 Oct 11;271(41):25533-8.
REF 16 Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J Biol Chem. 1996 Jun 14;271(24):14468-72.
REF 17 The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis. Biochem J. 2000 Sep 15;350 Pt 3:925-32.
REF 18 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999 Sep 3;274(36):25726-34.
REF 19 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 20 Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta. Cell Signal. 1998 Apr;10(4):283-90.
REF 21 Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. J Biol Chem. 1998 Jul 3;273(27):17186-91.
REF 22 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 23 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 24 Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity. 2008 Oct 17;29(4):578-88.
REF 25 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005 Mar;7(3):278-85.
REF 26 c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J. 1994 May 15;13(10):2341-51.
REF 27 The SH2-containing adapter protein GRB10 interacts with BCR-ABL. Oncogene. 1998 Aug 27;17(8):941-8.
REF 28 T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein. J Biol Chem. 2001 Sep 28;276(39):36174-82.
REF 29 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 30 Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyros... Biochem Biophys Res Commun. 2000 Apr 2;270(1):28-33.
REF 31 Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. J Biol Chem. 2001 Jun 1;276(22):18908-14.
REF 32 The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 1998 Oct 15;17(15):1893-901.
REF 33 Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Mol Cell Biol. 1999 Feb;19(2):1359-68.
REF 34 The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene. 1997 Nov 6;15(19):2257-65.
REF 35 Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J Cell Biol. 1999 Mar 8;144(5):1019-31.
REF 36 Differential regulation of cell motility and invasion by FAK. J Cell Biol. 2003 Mar 3;160(5):753-67.
REF 37 Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway. J Biol Chem. 2001 Jul 20;276(29):27090-7.
REF 38 Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. J Biol Chem. 1999 Feb 5;274(6):3811-8.
REF 39 Inhibition of p130cas tyrosine phosphorylation by calyculin A. J Leukoc Biol. 1998 May;63(5):631-5.
REF 40 Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood. 2000 Apr 15;95(8):2505-13.
REF 41 A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci. 2005 Feb 1;118(Pt 3):539-53.
REF 42 Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35.
REF 43 Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol. 2002 Feb 18;156(4):725-36.
REF 44 The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling. J Biol Chem. 2001 Apr 20;276(16):13417-26.
REF 45 Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. Biochim Biophys Acta. 1999 Nov 11;1452(2):179-87.
REF 46 DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol. 1996 Apr;16(4):1770-6.
REF 47 C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3443-7.
REF 48 Crk interacts with tyrosine-phosphorylated p116 upon T cell activation. J Biol Chem. 1995 Feb 17;270(7):2893-6.
REF 49 T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. J Biol Chem. 1998 Mar 13;273(11):6446-51.
REF 50 Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk. Eur J Immunol. 1997 Aug;27(8):2113-7.
REF 51 Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999 Feb 15;18(4):904-15.
REF 52 ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol. 1998 Dec;18(12):7038-51.
REF 53 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 54 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. Endocrinology. 2001 May;142(5):1835-40.
REF 55 Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. J Biol Chem. 1998 Jun 12;273(24):14780-7.
REF 56 Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J. 2002 Sep 2;21(17):4571-82.

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