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| Protein General Information (TTD Target) |
Top |
| Full Name |
Proto-oncogene c-Ret (RET)
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Successful
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Target Info
|
| UniProt ID |
RET_HUMAN
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| Gene Name |
RET
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| Gene ID |
5979
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| References |
Top |
| REF 1 |
EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression. Oncotarget. 2017 Apr 18;8(16):27155-27165.
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| REF 2 |
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol. 2004 Nov;24(21):9390-400.
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| REF 3 |
The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene. 1997 Nov 6;15(19):2257-65.
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| REF 4 |
PP1 inhibitor induces degradation of RETMEN2A and RETMEN2B oncoproteins through proteosomal targeting. Cancer Res. 2003 May 1;63(9):2234-43.
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