Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T29130 Target Info
Target Name Signal transducer and activator of transcription 3 (STAT3)
Synonyms Acute-phase response factor; APRF
Target Type Successful Target
Gene Name STAT3
Biochemical Class Transcription factor
UniProt ID
STAT3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Kinases [+] 9 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-Western [6]
3 Biochemical Activity [7]
4 Co-localization [8]
5 Protein-Fragment Complementation Assay [5]
6 Yeast two hybrid [9]
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
3 Co-localization [12]
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [14]
3 Reconstituted Complex [15]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-localization [17]
3 Reconstituted Complex [16]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Protein-peptide [19]
Interacting Target Name Proto-oncogene c-Ret (RET) Successful Target Interacting Protein Info
UniProt ID
RET_HUMAN 
Synonyms RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; PTC; Proto-oncogene tyrosine-protein kinase receptor Ret; C-ret; CDHR16; CDHF12; Cadherin family member 12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [20]
Interacting Target Name Janus kinase 1 (JAK-1) Successful Target Interacting Protein Info
UniProt ID
JAK1_HUMAN 
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Co-localization [20]
Interacting Target Name Tyrosine-protein kinase BMX (BMX) Patented-recorded Target Interacting Protein Info
UniProt ID
BMX_HUMAN 
Synonyms NTK38; ETK; Epithelial and endothelial tyrosine kinase; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Yeast two hybrid [25]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [22]
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Reconstituted Complex [28]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [30]
3 Co-localization [20]
4 Reconstituted Complex [31]
Interacting Target Name Nuclear factor NF-kappa-B (NFKB) Successful Target Interacting Protein Info
UniProt ID
NFKB2_HUMAN 
Synonyms Oncogene Lyt-10; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nuclear factor NF-kappa-Bp52 subunit; Nuclear factor NF-kappa-B p100 subunit; Lyt10; Lymphocyte translocation chromosome 10 protein; Lymphocyte translocation chromosome 10; H2TF1; DNA-binding factor KBF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Co-localization [33]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Biochemical Activity [2]
Interacting Protein Name Hypermethylated in cancer 1 protein (HIC1) Interacting Protein Interacting Protein Info
UniProt ID
HIC1_HUMAN 
Synonyms ZBTB29; ZNF901; hic.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [35]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [36]
References  Top
REF 1 Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science. 1999 Apr 16;284(5413):479-82.
REF 2 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005 Jan 14;307(5707):269-73.
REF 3 The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. J Cell Biochem. 2007 Dec 1;102(5):1256-70.
REF 4 Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. J Biol Chem. 2002 Mar 8;277(10):8004-11.
REF 5 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 6 Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol. 2004 Nov;24(21):9390-400.
REF 7 EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14;24(4):438-49.
REF 8 Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005 Jun;7(6):575-89.
REF 9 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 10 Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol. 2004 Jun;6(6):547-54.
REF 11 Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55.
REF 12 Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):105-12.
REF 13 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem. 2005 Jan 14;280(2):1037-43.
REF 14 mTORC1 drives HIF-1 and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene. 2015 Apr 23;34(17):2239-50.
REF 15 Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol. 2000 Jan 13;10(1):47-50.
REF 16 Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res. 2004 Aug 15;64(16):5870-5.
REF 17 HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28;24(19):3110-20.
REF 18 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J Biol Chem. 2002 Oct 11;277(41):38486-93.
REF 19 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 20 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 21 Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur J Haematol. 2001 Aug;67(2):63-71.
REF 22 Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem. 2002 Mar 1;277(9):7076-85.
REF 23 Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J Immunol. 2000 Aug 15;165(4):2116-23.
REF 24 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol. 2000 Mar;20(6):2043-54.
REF 25 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 26 Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells. Biochem Biophys Res Commun. 2001 Apr 27;283(1):179-87.
REF 27 STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem. 1997 Dec 5;272(49):30607-10.
REF 28 STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev. 2003 Oct 15;17(20):2564-77.
REF 29 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 30 Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. Biochem Biophys Res Commun. 2001 Oct 19;288(1):252-7.
REF 31 PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. 2005 Nov 10;24(49):7290-300.
REF 32 Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7264-9.
REF 33 STAT3 cooperates with the non-canonical NF-B signaling to regulate pro-labor genes in the human placenta. Placenta. 2015 May;36(5):581-6.
REF 34 Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell. 2001 Feb 9;104(3):365-76.
REF 35 HIC1 interacts with and modulates the activity of STAT3. Cell Cycle. 2013 Jul 15;12(14):2266-76.
REF 36 Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J. 2002 Oct 1;367(Pt 1):97-105.

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