Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T98264 Target Info
Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6)
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; Protein-tyrosine phosphatase 1C; PTP1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Target Type Patented-recorded Target
Gene Name PTPN6
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTN6_HUMAN 
Target Interacting Proteins  Top
Cytokine receptors [+] 2 Cytokine receptors +
Interacting Target Name Interleukin 4 receptor alpha (IL4R) Successful Target Interacting Protein Info
UniProt ID
IL4RA_HUMAN 
Synonyms Interleukin-4 receptor subunit alpha; IL-4R-alpha; IL-4RA; IL4RA; IL-4R subunit alpha; IL-4 receptor subunit alpha; CD124 antigen; CD124; 582J2.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Interleukin 3 receptor (CSF2RB) Clinical trial Target Interacting Protein Info
UniProt ID
IL3RB_HUMAN 
Synonyms IL5RB; IL-5R; IL3RB; GM-CSF/IL-3/IL-5 receptor common beta subunit; Cytokine receptor common subunit beta; CDw131; CD131
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
Kinases [+] 6 Kinases +
Interacting Target Name Tyrosine-protein kinase Kit (KIT) Successful Target Interacting Protein Info
UniProt ID
KIT_HUMAN 
Synonyms v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; p145 c-kit; Mast/stem cell growth factor receptor Kit; C-kit; CD117 antigen; CD117
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [5]
Interacting Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target Interacting Protein Info
UniProt ID
VGFR2_HUMAN 
Synonyms VEGFR-2; VEGFR2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; FLK-1; FLK1; Fetal liver kinase 1; CD309
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [6]
3 Yeast two hybrid [7]
Interacting Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target Interacting Protein Info
UniProt ID
FAK2_HUMAN 
Synonyms Related adhesion focal tyrosine kinase; RAFTK; PYK2; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAK-beta; CAKB; CADTK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Biochemical Activity [9]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Yeast two hybrid [7]
Interacting Target Name Tyrosine-protein kinase SYK (SYK) Successful Target Interacting Protein Info
UniProt ID
KSYK_HUMAN 
Synonyms Spleen tyrosine kinase; p72-Syk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [11]
Interacting Protein Name Breakpoint cluster region protein (BCR) Interacting Protein Interacting Protein Info
UniProt ID
BCR_HUMAN 
Synonyms ALL; BCR1; CML; D22S11; D22S662; PHL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) Interacting Protein Interacting Protein Info
UniProt ID
LAIR1_HUMAN 
Synonyms CD305; LAIR.1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [15]
3 Reconstituted Complex [15]
4 Yeast two hybrid [14]
5 Yeast two hybrid [16]
Interacting Target Name Platelet endothelial cell adhesion molecule (PECAM1) Literature-reported Target Interacting Protein Info
UniProt ID
PECA1_HUMAN 
Synonyms PECAM-1; PECA1; GPIIA'; EndoCAM; ECAM; CD31 antigen; CD31
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Far Western [18]
3 Reconstituted Complex [18]
Interacting Protein Name Lymphocyte cytosolic protein 2 (LCP2) Interacting Protein Interacting Protein Info
UniProt ID
LCP2_HUMAN 
Synonyms SLP.76; SLP76
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [20]
3 Reconstituted Complex [19]
Interacting Target Name B-cell receptor CD22 (CD22) Successful Target Interacting Protein Info
UniProt ID
CD22_HUMAN 
Synonyms T-cell surface antigen Leu-14; Siglec-2; SIGLEC2; Sialic acid-binding Ig-like lectin 2; Leu-14; B-lymphocyte cell adhesion molecule; BL-CAM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
Interacting Protein Name Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) Interacting Protein Interacting Protein Info
UniProt ID
SHPS1_HUMAN 
Synonyms BIT; CD172A; MFR; MYD.1; P84; PTPNS1; SHPS1; SIRP
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [23]
2 Yeast two hybrid [16]
References  Top
REF 1 The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Rec... J Biol Chem. 2016 Nov 25;291(48):24922-24930.
REF 2 Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. J Immunol. 2001 Dec 1;167(11):6382-7.
REF 3 SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates. J Biol Chem. 1997 May 30;272(22):14470-6.
REF 4 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998 Apr;18(4):2089-99.
REF 5 Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol. 1993 Jun;13(6):3350-8.
REF 6 TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J. 2017 May;31(5):2001-2012.
REF 7 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 8 Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem. 2000 Jun 9;275(23):17263-8.
REF 9 Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1. J Biol Chem. 1999 Oct 22;274(43):30657-63.
REF 10 Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C. J Biol Chem. 1995 Sep 8;270(36):21277-84.
REF 11 Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. J Immunol. 1999 Mar 1;162(5):2717-24.
REF 12 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 13 Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase. Oncogene. 1998 Oct 15;17(15):1889-92.
REF 14 Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. J Immunol. 2001 Feb 1;166(3):1763-70.
REF 15 Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 2000 Jun 9;275(23):17440-6.
REF 16 PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. J Biol Chem. 2000 Feb 11;275(6):4467-74.
REF 17 Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. J Biol Chem. 1998 Oct 23;273(43):28332-40.
REF 18 Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. FEBS Lett. 1999 Apr 30;450(1-2):77-83.
REF 19 Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med. 1996 Aug 1;184(2):457-63.
REF 20 SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem. 1998 Oct 16;273(42):27518-23.
REF 21 SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001 Jul 13;276(28):26648-55.
REF 22 Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. J Biol Chem. 1999 Jan 22;274(4):2303-7.
REF 23 Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1. J Biol Chem. 2000 Feb 11;275(6):4066-71.

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