Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Tyrosine-protein kinase Kit (SCFR) | Successful | Target Info | ||
UniProt ID | KIT_HUMAN | ||||
Gene Name | KIT | ||||
Gene ID | 3815 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [1] | |
Interacting Patented-recorded Target(s) | Signal transducer and activator of transcription 1 (STAT1) | Target Info | PPI Info | [2] | |
Tyrosine-protein kinase Tec (PSCTK4) | Target Info | PPI Info | [3] | ||
Protein-tyrosine phosphatase SHP-1 (PTPN6) | Target Info | PPI Info | [4] | ||
Interacting Literature-reported Target(s) | Mast cell growth factor (MGF) | Target Info | PPI Info | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J. 2003 Mar 15;370(Pt 3):1033-8. | ||||
REF 2 | Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J. 1997 Oct 1;327 ( Pt 1):73-80. | ||||
REF 3 | Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood. 2000 Nov 15;96(10):3406-13. | ||||
REF 4 | SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998 Apr;18(4):2089-99. | ||||
REF 5 | A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. J Biol Chem. 1992 May 25;267(15):10866-73. |
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