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| Target General Information |
Top |
| Target ID |
T15848 |
Target Info
|
| Target Name |
Tyrosine-protein kinase Tec (PSCTK4) |
| Synonyms |
Tec protein tyrosine kinase |
| Target Type |
Patented-recorded Target |
| Gene Name |
TEC |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Tyrosine-protein kinase Kit (KIT) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; p145 c-kit; Mast/stem cell growth factor receptor Kit; C-kit; CD117 antigen; CD117 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Protein Name |
Docking protein 1 (DOK1) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
P62DOK |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[1] |
| 3 |
Biochemical Activity |
[3] |
| References |
Top |
| REF 1 |
Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood. 2000 Nov 15;96(10):3406-13.
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| REF 2 |
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol. 1994 Dec;14(12):8432-7.
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| REF 3 |
Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. J Biol Chem. 2002 Apr 19;277(16):13732-8.
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