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| Target General Information |
Top |
| Target ID |
T90089 |
Target Info
|
| Target Name |
Mast cell growth factor (MGF) |
| Synonyms |
sKITLG; cKit ligand; c-Kit ligand; Stem cell factor; Soluble KIT ligand; SCF; Kit ligand |
| Target Type |
Literature-reported Target |
| Gene Name |
KITLG |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Tyrosine-protein kinase Kit (KIT) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; p145 c-kit; Mast/stem cell growth factor receptor Kit; C-kit; CD117 antigen; CD117 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. J Biol Chem. 1992 May 25;267(15):10866-73.
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| REF 2 |
Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. J Biol Chem. 1993 Feb 25;268(6):4399-406.
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