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| Target General Information |
Top |
| Target ID |
T29083 |
Target Info
|
| Target Name |
Proto-oncogene c-Fes (FES) |
| Synonyms |
p93c-fes; Tyrosine-protein kinase Fes/Fps; Proto-oncogene c-Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; FPS |
| Target Type |
Literature-reported Target |
| Gene Name |
FES |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Protein Name |
Breakpoint cluster region protein (BCR) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
ALL; BCR1; CML; D22S11; D22S662; PHL |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl. Cancer Res. 2000 Feb 15;60(4):1097-103.
|
| REF 2 |
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. Mol Cell Biol. 1995 Feb;15(2):835-42.
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