Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89034 | Target Info | |||
| Target Name | Plasminogen (PLG) | ||||
| Synonyms |
Plasmin
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|
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| Target Type | Successful Target | ||||
| Gene Name | PLG | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 171 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
BOCEPREVIR
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|
Approved | Compound Info | ||
| Synonyms |
Boceprevir; Victrelis; 394730-60-0; SCH 503034; EBP 520; UNII-89BT58KELH; SCH-503034; 89BT58KELH; CHEBI:68621; (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
TAK-442
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Letaxaban; TAK-442; 870262-90-1; UNII-Y3WB03966W; TAK 442; CHEMBL1095032; Y3WB03966W; 1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl}piperidin-4-yl)tetrahydropyrimidin-2(1H)-one; 2(1H)-Pyrimidinone,1-[1-[(2S)-3-[(6-chloro-2-naphthalenyl)sulfonyl]-2-hydroxy-1-oxopropyl]-4-piperidinyl]tetrahydro-; Letaxaban [USAN:INN]; 1-[1-[(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl]piperidin-4-yl]tetrahydropyrimidin-2(1H)-one; 3kl6; Letaxaban (USAN/INN); SCHEMBL766143; GEHAEMCVKDPMKO-HXUWFJFHSA-N
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| Activity |
IC50 ~ 60000 nM
|
[2] | |||
| Compound Name |
2-Propionyl-1H-indole-6-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL321960; 2-Propionyl-1H-indole-6-carboxamidine
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| Activity |
Ki = 61500 nM
|
[3] | |||
| Compound Name |
4-chloro-1-guanidino-7-isoquinolinesulphonamide
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Investigative | Compound Info | ||
| Synonyms |
223671-02-1; 1-GUANIDINO-4-CHLORO-7-SULFAMOYL-ISOQUINOLINE; 4-chloro-1-guanidino-7-isoquinolinesulphonamide; 2-(4-chloro-7-sulfamoylisoquinolin-1-yl)guanidine; CHEMBL227782; SCHEMBL6437735; CTK4E9305; BDBM16132; DTXSID90586545; FXVHAOFNNRNCRJ-UHFFFAOYSA-N; AKOS015966420; 1-guanidino-7-sulfonamidoisoquinoline 6; ACM223671021; 4-chloro-1-guanidino-7-sulphamoylisoquinoline
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(3-Nitro-benzyl)-1H-indole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329730; 1-(3-Nitro-benzyl)-1H-indole-5-carboxamidine; BDBM50027293
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Indol-1-ylmethyl-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
1-(4-Amidinobenzyl)indole; 83783-25-9; CHEMBL100569; 4-ABI; 4-Indol-1-ylmethyl-benzamidine; 4-(1h-indol-1-ylmethyl)benzenecarboximidamide; AC1L34FF; AC1Q1U95; CTK5F1124; DTXSID50232637; ZINC5162918; BDBM50027305; AKOS030584119; 4-((1h-indol-1-yl)methyl)benzimidamide; 4-(indol-1-ylmethyl)benzenecarboximidamide; KB-214170; Benzenecarboximidamide,4-(1H-indol-1-ylmethyl)-; Benzenecarboximidamide, 4-(1H-indol-1-ylmethyl)-
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| Activity |
Ki = 111000 nM
|
[3] | |||
| Compound Name |
1-(3-Amino-benzyl)-1H-indole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319122; 1-(3-Amino-benzyl)-1H-indole-5-carboxamidine; ZINC26750418
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| Activity |
Ki = 164000 nM
|
[3] | |||
| Compound Name |
[4-((S)-1-Allyl-pyrrolidin-3-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL342568; BDBM50068498
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184715; BDBM50152748
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059991; BDBM50256261
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl365415
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371797; BDBM50152752
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(2-{2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-3,3-difluoro-propyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414805; BDBM50152750
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(5,5-dimethyl-3-oxo-cyclohex-1-enyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL147789; BDBM50068491
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(5,5-dimethyl-3-oxo-cyclohex-1-enyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356973; BDBM50068484
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
Chembl432400
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370338; BDBM50079381
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| Activity |
Ki = 50000 nM
|
[8] | |||
| Compound Name |
(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094403; BDBM50256260
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl364471
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371795; BDBM50152753
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184035; BDBM50152751
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
VX-950, Telaprevir; CHEMBL443336; CYC142; SCHEMBL1709083; SCHEMBL16556602; CTK5A5985; DTXSID00389004; AKOS015896277; AC-5241; AB01566825_01
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| Activity |
Ki ~ 50000 nM
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[6] | |||
| Compound Name |
Chembl184525
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371796; BDBM50152755
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| Activity |
Ki ~ 50000 nM
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[6] | |||
| Compound Name |
(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315390; SCHEMBL13091808; BDBM50137739
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070056; BDBM50256262
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| Activity |
Ki ~ 50000 nM
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[7] | |||
| Compound Name |
N-(7-Bromo-isoquinolin-1-yl)-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL321848; Guanidine, N-(7-bromo-1-isoquinolinyl)-; BDBM50147406
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| Activity |
Ki = 50800 nM
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[9] | |||
| Compound Name |
Naphthalene-2-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
beta-Naphthamidine; Naphthalene-2-carboxamidine; 2-Naphthalenecarboximidamide; 2-Naphthimidamide; CHEMBL105171; 2-naphthamidine; uPa_6; 2-Naphthalenecarboxamidine; SCHEMBL3370031; CTK1H2194; DTXSID40205052; ZINC1442764; BDBM50138663; AKOS009312986; DA-04828; SC-41036; FT-0763708; Q27453295; Z2146514452
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| Activity |
Ki = 51000 nM
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[10] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238374; BDBM50009200
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| Activity |
IC50 = 51000 nM
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[11] | |||
| Compound Name |
3-(3-Amidinophenyl)-2-[[[(4-thiocarbamoylphenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336844; BDBM50067528
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| Activity |
Ki = 52000 nM
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[12] | |||
| Compound Name |
(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL344305; BDBM50068506
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| Activity |
Ki = 52000 nM
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[5] | |||
| Compound Name |
4-[7-(1,1-Dimethyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-ylmethyl]-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77215; SCHEMBL7980030; BDBM50129977
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| Activity |
IC50 = 53000 nM
|
[13] | |||
| Compound Name |
Chembl4226631
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8008313; BDBM50460468
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| Activity |
Ki ~ 53400 nM
|
[14] | |||
| Compound Name |
3-[3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107429; BDBM50060060
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| Activity |
Ki = 55000 nM
|
[15] | |||
| Compound Name |
3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303970; BDBM50115898
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| Activity |
Ki = 55000 nM
|
[16] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-2-[[2,5-dioxo-3-(4-pyridin-4-yloxyphenyl)imidazolidin-1-yl]methyl]-3-methylbenzimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585746; BDBM50093540
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| Activity |
IC50 = 56000 nM
|
[17] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341933; BDBM50067526; 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(4-carbamimidoyl-phenyl)-propionic acid
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| Activity |
Ki = 57000 nM
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[12] | |||
| Compound Name |
Diphenyl 1-acetamido-2-(4-guanidinophenyl)ethylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239747; SCHEMBL12354633; BDBM50228414; N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]acetamide
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| Activity |
IC50 = 57000 nM
|
[18] | |||
| Compound Name |
3-(3-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135998; BDBM50067524
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| Activity |
Ki = 57000 nM
|
[12] | |||
| Compound Name |
N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-(2-phenyl-ethanesulfonylamino)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415741; BDBM50110010; N-(Phenethylsulfonyl)-D-Ser-Gly-(4-amidinobenzyl)NH2
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| Activity |
Ki = 59000 nM
|
[19] | |||
| Compound Name |
5-[4-[3-(6-Chloro-2-naphthylsulfonyl)propanoyl]piperazino]imidazo[1,2-a]pyridine-2-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259603; BDBM50231646
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| Activity |
Ki ~ 60000 nM
|
[20] | |||
| Compound Name |
4-[3-Oxo-4-methyl-7-[1-(piperidinocarbonyl)-1-methylethyl]-3,4-dihydroquinoxaline-2-ylmethyl]benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72308; BDBM50129968
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| Activity |
IC50 = 60000 nM
|
[13] | |||
| Compound Name |
2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)propanoyl)piperidin-4-yl)-5-methyl-1H-imidazo[1,5-c]imidazol-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487105; SCHEMBL948339; BDBM50270656
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| Activity |
Ki ~ 60000 nM
|
[21] | |||
| Compound Name |
1beta,5beta-Bis[4-(4-amidinophenethylcarbamoyl)piperazinocarbonyloxy]cyclooctane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310760; SCHEMBL7418203; BDBM50093185
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| Activity |
Ki = 60000 nM
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[22] | |||
| Compound Name |
2-(5-Methyl-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433179; BDBM50102793; ZINC13863688; 2-(2-Hydroxy-5-methyl-phenyl)-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki = 60000 nM
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[23] | |||
| Compound Name |
1-(4-Carbamimidoyl-benzyl)-1H-indole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101067; SCHEMBL1816368; BDBM50027304; 1-[(4-carbamimidoylphenyl)methyl]indole-5-carboximidamide
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| Activity |
Ki = 60000 nM
|
[3] | |||
| Compound Name |
2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)propanoyl)piperidin-4-yl)-5-(hydroxymethyl)-1H-imidazo[1,5-c]imidazol-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593482; SCHEMBL947331; BDBM50304620
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| Activity |
Ki ~ 60000 nM
|
[24] | |||
| Compound Name |
2-(3-Methyl-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL92964; BDBM50102772; ZINC13863693; 2-(2-Hydroxy-3-methyl-phenyl)-1H-benzoimidazole-5-carboxamidine
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| Activity |
Ki = 60000 nM
|
[23] | |||
| Compound Name |
(S)-2-(1-(3-(6-Chloronaphthalen-2-ylsulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)-5-methyl-1H-imidazo[1,5-c]imidazol-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593461; SCHEMBL949001; BDBM50304619
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| Activity |
Ki ~ 60000 nM
|
[24] | |||
| Compound Name |
Methyl 3-[4-[(6-methoxynaphthalen-2-yl)sulfonylamino]phenyl]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945918; BDBM50363664
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| Activity |
IC50 ~ 62000 nM
|
[25] | |||
| Compound Name |
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324168; 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE; uPa_9; N-[4-(aminomethyl)phenyl]-6-carbamimidoylnaphthalene-2-carboxamide; SCHEMBL4330440; ZINC2047485; BDBM50138662; DB02398; Q27093399; N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide; N-[4-(Aminomethyl)phenyl]-6-amidino-2-naphthalenecarboxamide; 6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-aminomethyl-phenyl)-amide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 62000 nM
|
[25] | |||
| Compound Name |
1,5-Di{4-[4-amino(imino)methylphenylcarboxamidomethyl]hexahydro-1-pyridinylcarbonyloxy}cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43938; SCHEMBL7419625; BDBM50101011
Click to Show/Hide
|
||||
| Activity |
Ki = 62200 nM
|
[26] | |||
| Compound Name |
3-(Dimethylamino)benzenecarboximidamide;2,4,6-trinitrophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392242
Click to Show/Hide
|
||||
| Activity |
Ki = 63095.73 nM
|
[27] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(4-methoxyphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238375; BDBM50009201
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[11] | |||
| Compound Name |
3-Amino-N-{3-[(S)-2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(4-aminomethyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462253; BDBM50253981
Click to Show/Hide
|
||||
| Activity |
Ki = 64800 nM
|
[28] | |||
| Compound Name |
2-[4-Chloro-7-({1-[(4-methylpiperazin-1-yl)carbonyl]cyclopentyl}sulfamoyl)isoquinolin-1-yl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
cycloleucine deriv. 45; CHEMBL226714; SCHEMBL6436023; BDBM16171; 2-[4-chloro-7-[[1-(4-methylpiperazine-1-carbonyl)cyclopentyl]sulfamoyl]isoquinolin-1-yl]guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 65000 nM
|
[4] | |||
| Compound Name |
1-(3-Carbamimidoyl-benzyl)-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101726; BDBM50027291
Click to Show/Hide
|
||||
| Activity |
Ki = 65600 nM
|
[3] | |||
| Compound Name |
4-{4-Methyl-3-oxo-7-[1-(pyrrolidine-1-carbonyl)-cyclopropyl]-3,4-dihydro-quinoxalin-2-ylmethyl}-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431577; SCHEMBL7968288; BDBM50129976
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[13] | |||
| Compound Name |
1beta,5beta-Bis[4-[3-(4-amidinophenyl)propionyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448786; SCHEMBL7428430; BDBM50093154
Click to Show/Hide
|
||||
| Activity |
Ki = 66000 nM
|
[22] | |||
| Compound Name |
4-(Aminomethyl)-N-[(2S)-3-(4-hydroxyphenyl)-1-(octylamino)-1-oxopropan-2-yl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752312; BDBM50138838
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[29] | |||
| Compound Name |
N-Isoquinolin-1-yl-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321822; Guanidine, N-1-isoquinolinyl-; 2-isoquinolin-1-ylguanidine; 1-(isoquinolin-1-yl)guanidine; SCHEMBL6435471; BDBM50147412
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[9] | |||
| Compound Name |
[(1-{1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76068; BDBM50129978
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[13] | |||
| Compound Name |
1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308600; BDBM50129970
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[13] | |||
| Compound Name |
Methyl (2S)-1-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492334; BDBM50257762
Click to Show/Hide
|
||||
| Activity |
Ki = 69400 nM
|
[30] | |||
| Compound Name |
(6S,8S,8As)-6-benzyl-N-[(4-carbamimidoylphenyl)methyl]-6-hydroxy-8-methoxy-5-oxo-1,2,3,7,8,8a-hexahydroindolizine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542434
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[31] | |||
| Compound Name |
Substituted glycine deriv. 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227890; BDBM16157
Click to Show/Hide
|
||||
| Activity |
Ki = 71000 nM
|
[4] | |||
| Compound Name |
Tetrasodium;[4-[4-oxo-5-[2-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxyethoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087435; BDBM50260054
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[32] | |||
| Compound Name |
4-{7-[1-(2-Hydroxymethyl-pyrrolidine-1-carbonyl)-cyclopropyl]-4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-ylmethyl}-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307385; BDBM50129974
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[13] | |||
| Compound Name |
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[3-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079552; BDBM50260052
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[32] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-pyridin-4-yloxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585745; BDBM50093541
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[17] | |||
| Compound Name |
(3S,6S,9As)-6-acetamido-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557616
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[33] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60478; BDBM50115877
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-(3,4,5-triisopropyl-benzenesulfonylamino)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157131; BDBM50110026
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[19] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64653; BDBM50115889
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64654; BDBM50115894
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
2-[1-Methyl-2-oxo-3-(4-amidinobenzyl)-1,2-dihydroquinoxaline-6-yl]isobutyric acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74701; BDBM50129973
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[13] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63050; BDBM50115880
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
n-(4-Carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62897; N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; BDBM14159; APC-11421; DB06857; Q27095762; N-(3-Chloro-4-amidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294509; BDBM50115905
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304219; BDBM50115902
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[16] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303335; BDBM50115883; N-(4-Guanidinophenyl)-2-hydroxybenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
4-Ethoxy-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63038; BDBM50115887
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64164; BDBM50115888; N-(4-Guanidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59936; BDBM50115899
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63216; BDBM50115896
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64841; BDBM50115897; Benzamide,N-[4-[(aminoiminomethyl)amino]phenyl]-2-hydroxy-5-methyl-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[16] | |||
| Compound Name |
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[4-[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxybutoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095129; BDBM50260058
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[32] | |||
| Compound Name |
Chembl4227743
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10264235; BDBM50460457
Click to Show/Hide
|
||||
| Activity |
Ki = 76600 nM
|
[14] | |||
| Compound Name |
(3S)-N-[2'-(Aminosulfonyl)-4-biphenylyl]-2-(3-amidinobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3alpha-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98858; BDBM50106064
Click to Show/Hide
|
||||
| Activity |
IC50 = 77900 nM
|
[34] | |||
| Compound Name |
Planktocyclin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400366; cyclo(Pro-Gly-Leu-Val-Met-Phe-Gly-Val); BDBM50224807
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[35] | |||
| Compound Name |
(2R,3R)-2-Amino-N-[(2S)-1-[[(1S)-5-amino-1-cyanopentyl]amino]-1-oxo-3-phenylpropan-2-yl]-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910421; BDBM50355952
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[36] | |||
| Compound Name |
4-[(2-Carbamimidoyl-3,4-dihydro-1H-isoquinolin-7-yl)oxymethyl]-1-pyrimidin-4-ylpiperidine-4-carboxylic acid;methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195428
Click to Show/Hide
|
||||
| Activity |
Ki = 78200 nM
|
[37] | |||
| Compound Name |
4-[(2-Carbamimidoyl-3,4-dihydro-1H-isoquinolin-7-yl)oxymethyl]-1-pyridin-4-ylpiperidine-4-carboxylic acid;sulfurous acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216829
Click to Show/Hide
|
||||
| Activity |
Ki = 78200 nM
|
[38] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL495010; BDBM50257811
Click to Show/Hide
|
||||
| Activity |
Ki = 79000 nM
|
[30] | |||
| Compound Name |
2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330460; BDBM50102781; 2-[4-(Diethylamino)-2-hydroxyphenyl]-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[23] | |||
| Compound Name |
1,4-Bis[[(S)-1-methyl-2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80149; BDBM50093137
Click to Show/Hide
|
||||
| Activity |
Ki = 83000 nM
|
[39] | |||
| Compound Name |
N-[(S)-alpha-[4-(2-Fluoroethyl)piperidinocarbonyl]-4-aminobenzyl]-4-[[(S)-alpha-(hydroxymethyl)phenethyl]amino]pyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL12506; BDBM50076819
Click to Show/Hide
|
||||
| Activity |
Ki ~ 86000 nM
|
[40] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(pyridin-4-ylmethoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238376; BDBM50009202
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[11] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(3R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370424; BDBM50046352
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[41] | |||
| Compound Name |
n-(4-Carbamimidoyl-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(4-carbamimidoylphenyl)-2-hydroxybenzamide; CHEMBL64708; SCHEMBL7244941; BDBM14155; APC-7136; N-(4-Amidinophenyl)-2-hydroxybenzamide; Q27451646
Click to Show/Hide
|
||||
| Activity |
Ki = 90000 nM
|
[16] | |||
| Compound Name |
{1-(4-Fluoro-phenyl)-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370416; BDBM50046364
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[41] | |||
| Compound Name |
(S)-5-Guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569280; BDBM50303777
Click to Show/Hide
|
||||
| Activity |
Ki = 97000 nM
|
[42] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-carbamoylphenoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238378; BDBM50009204
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[11] | |||
| Compound Name |
(2S,3S)-N-[(2S)-1-[[2-(Butylamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2182019; BDBM50398078
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[43] | |||
| Compound Name |
4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945236; BDBM50363655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
1-Guanidino-7-sulfonamidoisoquinoline 14
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227584; BDBM16140; 3-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)propanoic acid; 3-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Cyclic deriv. 35
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388780; SCHEMBL6434405; BDBM16161; (2R)-1-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylpiperidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
m-Aminobenzamidine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzamidine, m-amino-, monohydrochloride; Benzenecarboximidamide, 3-amino-, monohydrochloride; 3-aminobenzamidine hydrochloride; CHEMBL3247186; 3-Aminobenzenecarboximidamide monohydrochloride; EINECS 222-400-6; SCHEMBL5899967; DTXSID90188149; 3-aminobenzenecarboxamidine, chloride; BDBM50010250; AKOS024374896; GS-5441; MCULE-7810215961; KS-0000261T; 3-aminobenzenecarboximidamide;hydrochloride; FT-0758040; ST51014895; 3-aminobenzene-1-carboximidamide hydrochloride; Benzenecarboximidamide, 3-amino-, monohydrochloride (9CI)
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||||
| Activity |
Ki = 100000 nM
|
[27] | |||
| Compound Name |
4-(1H-Tetrazol-5-YL)piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
4-(2H-1,2,3,4-tetrazol-5-yl)piperidine; 4-(2H-TETRAZOL-5-YL)PIPERIDINE; Piperidine, 4-(1H-tetrazol-5-yl)-; CHEMBL1917055; 5-(4-piperidyl)-1H-1,2,3,4-tetraazole; Piperidine, 4-(2H-tetrazol-5-yl)-; ACMC-20mgn9; 4-(Tetrazol-5-yl)piperidine; SCHEMBL689874; SCHEMBL15549912; CTK0G1457; C6H11N5; DTXSID40626243; 4-(1H-tetrazol-5-yl)-piperidine; 4-(2H-tetrazol-5-yl)-piperidine; ALBB-012879; 8951AC; BDBM50428066; MFCD13188625; SBB051646; STL433196; ZINC40457319; AKOS005173884; MCULE-9575824549; PB37002; SB19876; AS-35786; DA-18471; 4-(1H-1,2,3,4Tetrazol-5-yl)piperidine; 4-(1H-tetrazol-5-yl)piperidine(SALTDATA; AB0073777; ST4150691; CS-0057218; FT-0683647; 4-(1H-1,2,3,4-tetraazol-5-yl)piperidine; 4-(1H-Tetrazol-5-yl)piperidine, AldrichCPR; Y-7402
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||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
Substituted glycine deriv. 16
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227664; BDBM16142; 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}(methyl)sulfonamido)acetic acid
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Cycloleucine deriv. 42
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427456; SCHEMBL6450696; BDBM16168
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
N-((1R,2S,5S)-2-(5-Chloro-1H-indole-2-carboxamido)-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-C]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479863; SCHEMBL763988; BDBM35743; cis-1,2-diaminocyclohexane derivative, A; Q27459737
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||||
| Activity |
Ki ~ 100000 nM
|
[45] | |||
| Compound Name |
2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-azaspiro[3.5]nonane-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441773; BDBM50442864
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(2-(3-(4-(Aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL208638; BDBM50184499
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
2-((R)-3-{(R)-3-[(S)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-oxo-cyclohexyl}-propionylamino)-3-phenyl-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339594; BDBM50081425
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|
||||
| Activity |
Ki = 100000 nM
|
[47] | |||
| Compound Name |
5-(1-Methylpiperidin-4-yl)-1,2-oxazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287842; SCHEMBL15451916; BDBM50020027
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|
||||
| Activity |
IC50 = 100000 nM
|
[48] | |||
| Compound Name |
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-phenylbutanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327113; BDBM50046363; 1-(2-Phenyl-pentanoyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide
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||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[2-[2-[2-[2-[2-[2-[2-[2-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-10-[ethoxy(fluoro)phosphoryl]decanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377737; BDBM50410911
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||||
| Activity |
Ki ~ 100000 nM
|
[49] | |||
| Compound Name |
(S)-1-(9-Hydroxy-9H-3-aza-fluorene-9-carbonyl)-pyrrolidine-2-carboxylic acid 2-aminomethyl-5-chloro-benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372449; BDBM50164263
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||||
| Activity |
Ki ~ 100000 nM
|
[50] | |||
| Compound Name |
Substituted glycine deriv. 17
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228172; BDBM16143; 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}(phenyl)sulfonamido)acetic acid; 2-(N-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylanilino)acetic acid
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Cycloleucine deriv. 40
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228173; SCHEMBL6433828; BDBM16166; N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]cycloleucine ethyl ester; N-[(4-chloro-1-guanidino7-isoquinolinyl)sulphonyl]cycloleucine ethyl ester; N-[(4-chloro-1guanidino-7-isoquinolinyl)sulphonyl]cycloleucine ethyl ester; N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]cyclo-leucine ethyl ester
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-N,N-dimethyl-isobutyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308604; BDBM50129972
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||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740183; BDBM50499900
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238369; BDBM50009178
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|
||||
| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
2-[4-Chloro-7-(cyclopentylsulfamoyl)isoquinolin-1-yl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL390310; SCHEMBL6437267; BDBM16133; AKOS015966419; 1-guanidino-7-sulfonamidoisoquinoline 7; 1-Guanidino-4-chloro-7-cyclopentylsulfamoyl-isoquinoline
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-2-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-3-methylbenzimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585742; BDBM50093542
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||||
| Activity |
IC50 = 100000 nM
|
[52] | |||
| Compound Name |
Cyclic deriv. 34
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228238; BDBM16160
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|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
1-({4-Chloro-1-[(Diaminomethylidene)amino]isoquinolin-7-Yl}sulfonyl)-D-Proline
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Investigative | Compound Info | ||
| Synonyms |
cyclic deriv. 33; CHEMBL227990; SCHEMBL6434295; BDBM16159; (2R)-1-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylpyrrolidine-2-carboxylic Acid; Q27464723; N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-D-proline
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Cycloleucine deriv. 43
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227931; SCHEMBL6448314; BDBM16169
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|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
Substituted glycine deriv. 24
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266435; BDBM16150
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||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(2-Amino-4-nitro-benzyl)-1H-indole-5-carboxamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101559; BDBM50027290
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|
||||
| Activity |
Ki = 100000 nM
|
[3] | |||
| Compound Name |
(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599872; SCHEMBL3263999; BDBM50326055
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Substituted glycine deriv. 18
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227995; BDBM16144; 2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-})sulfonamido]acetic acid; 2-[benzyl-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[(2S)-3-(1,3-Benzothiazol-2-yl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290025; BDBM50090226
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||||
| Activity |
Ki = 109000 nM
|
[53] | |||
| Compound Name |
Amino-N-(3,5-bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644917; BDBM50333193
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||||
| Activity |
Ki = 110000 nM
|
[54] | |||
| Compound Name |
1H-Indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
1H-Indole-5-carboxamidine; 5-Amidinoindole; CHEMBL26490; SCHEMBL563181; CTK2I0095; ZINC1439372; 4714AH; BDBM50027306; AKOS006352033; AB18264; SC-58549; DB-074491; FT-0756503
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||||
| Activity |
Ki = 112000 nM
|
[3] | |||
| Compound Name |
(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 5-chloro-2-cyclopropylcarbamoylmethoxy-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108202; BDBM50066333; N-[2-(Cyclopropylcarbamoylmethoxy)-5-chlorobenzyl]-1-[(R)-2-cyclohexylglycyl]-L-prolinamide
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||||
| Activity |
Ki = 113000 nM
|
[55] | |||
| Compound Name |
2-(3,4-Dihydroxyphenyl)-5-[[4-[[2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxochromen-5-yl]oxymethyl]phenyl]methoxy]-3,7-dihydroxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069227; BDBM50260050
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|
||||
| Activity |
IC50 = 116000 nM
|
[32] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2R)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332612; BDBM50431215
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||||
| Activity |
Ki = 118300 nM
|
[56] | |||
| Compound Name |
(2S)-5-Amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332616; BDBM50431219
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|
||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332613; BDBM50431224
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|
||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332605; BDBM50431216
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||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
Chembl2332604
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448529; BDBM50431213
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|
||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-Amino-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-aminopropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332611; BDBM50431217
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|
||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332615; BDBM50431223
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|
||||
| Activity |
Ki ~ 120000 nM
|
[56] | |||
| Compound Name |
Tetrasodium;[4-[4-oxo-5-[(E)-4-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxybut-2-enoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060852; BDBM50260046
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|
||||
| Activity |
IC50 = 121000 nM
|
[32] | |||
| Compound Name |
Methyl 3-[4-[(6-carbamoylnaphthalene-2-carbonyl)amino]phenyl]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945669; BDBM50363656
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|
||||
| Activity |
IC50 ~ 125000 nM
|
[25] | |||
| Compound Name |
Diphenyl 1-(2,3,6-tri-isopropylbenzenesulfonyl)amino-2-(4-guanidinophenyl)-ethanephosphonate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL391916; BDBM50228411
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|
||||
| Activity |
IC50 = 125000 nM
|
[18] | |||
| Compound Name |
3-Benzylbenzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3247185; 3-benzylbenzenecarboximidamide; BDBM50010249; ZINC39191567
Click to Show/Hide
|
||||
| Activity |
Ki = 125892.54 nM
|
[27] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238362; BDBM50009171
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[11] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(cyanomethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238373; BDBM50009199
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|
||||
| Activity |
IC50 = 130000 nM
|
[11] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[3-(3-methyl-2-oxo-1,3-benzoxazol-6-yl)-2,5-dioxoimidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585738; BDBM50093549
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[17] | |||
| Compound Name |
N-(6-Bromo-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107871; Guanidine, N-(6-bromo-1-isoquinolinyl)-; BDBM50147403
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|
||||
| Activity |
Ki = 131400 nM
|
[9] | |||
| Compound Name |
1beta,5beta-Bis[4-(4-amidinobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL298256; SCHEMBL7416220; BDBM50093187; 1,5-di{4-[4-amino(imino)methylbenzylcarbamoyl]hexahydro-1-pyrazinylcarbonyloxy}cyclooctane
Click to Show/Hide
|
||||
| Activity |
Ki = 134000 nM
|
[26] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[3-[1-[(4-fluorophenyl)methyl]indol-3-yl]propanoylamino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910642; BDBM50355960
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[36] | |||
| Compound Name |
N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-(2-phenyl-ethenesulfonylamino)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352009; BDBM50110006; N-[[(E)-Styryl]sulfonyl]-D-Ser-Gly-(4-amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[19] | |||
| Compound Name |
(1R,6S,8S,8As)-6-amino-N-[(4-carbamimidoylphenyl)methyl]-6-(cyclohexen-1-ylmethyl)-1-ethyl-8-methoxy-5-oxo-1,2,3,7,8,8a-hexahydroindolizine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544558
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[31] | |||
| Compound Name |
(2S)-N-[(1R,2S)-3-Cyclohexyl-1-hydroxy-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[[(2S)-2-[4-(diaminomethylideneamino)butanoylamino]-3-phenylpropanoyl]amino]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308232; BDBM50039010; BMS-182627
Click to Show/Hide
|
||||
| Activity |
IC50 = 143000 nM
|
[57] | |||
| Compound Name |
3(2H)-Isoxazolone, 5-(4-methyl-4-piperidinyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1192583; CHEMBL543840; BDBM50020030; BDBM50113822; 5-(4-Methyl-piperidin-4-yl)-isoxazol-3-ol; hydrobromide
Click to Show/Hide
|
||||
| Activity |
IC50 = 146000 nM
|
[48] | |||
| Compound Name |
2-[(6-Amino-5-carbamimidoyl-3-chloropyrazin-2-yl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013182; SCHEMBL10087502; BDBM50379657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[58] | |||
| Compound Name |
5-[(2S,4R)-2-Benzylpiperidin-4-yl]-1,2-oxazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287846; SCHEMBL582064; BDBM50020032
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[48] | |||
| Compound Name |
(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2-carbamoylmethoxy-5-chloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108717; BDBM50066332; N-[2-(Carbamoylmethoxy)-5-chlorobenzyl]-1-[(R)-2-cyclohexylglycyl]-L-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 152000 nM
|
[55] | |||
| Compound Name |
1beta,5beta-Bis[4-(4-amidinophenylacetyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311482; BDBM50093192
Click to Show/Hide
|
||||
| Activity |
Ki = 155000 nM
|
[22] | |||
| Compound Name |
2-(5-Chloro-2-Thienyl)-N-{(3s)-1-[(1s)-1-Methyl-2-Morpholin-4-Yl-2-Oxoethyl]-2-Oxopyrrolidin-3-Yl}ethenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GW-813893; UNII-1Y3JD5PEMS; 1Y3JD5PEMS; CHEMBL220050; SCHEMBL675586; SCHEMBL675588; BDBM17643; DB07278; GW813893; N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1f; Q27096505
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 158000 nM
|
[59] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(2-oxo-3-propyl-1,3-benzoxazol-6-yl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585739; BDBM50093548
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[17] | |||
| Compound Name |
(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422533; BDBM50110005; Cbz-D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[19] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-carbamoylphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238366; BDBM50009175
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[11] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-thiocarbamoylphenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137311; BDBM50067527
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[12] | |||
| Compound Name |
1-(2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289395; BDBM50057826
Click to Show/Hide
|
||||
| Activity |
Ki = 165000 nM
|
[60] | |||
| Compound Name |
5-[(2R,4R)-2-Benzylpiperidin-4-yl]-1,2-oxazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287848; SCHEMBL581882; BDBM50020034
Click to Show/Hide
|
||||
| Activity |
IC50 = 169000 nM
|
[48] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[3-carbamoyl-4-(pyridin-4-ylmethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233150; BDBM50009206
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[11] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-dicyclohexylpropanoyl)pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555333
Click to Show/Hide
|
||||
| Activity |
Ki = 176000 nM
|
[61] | |||
| Compound Name |
2-(3,5-Dichloro-4-methyl-2-pyridinyl)guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55808; BDBM50108352; N-(3,5-Dichloro-4-methyl-pyridin-2-yl)-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 176500 nM
|
[62] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-methoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238363; BDBM50009172
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[11] | |||
| Compound Name |
2-[4-({5-[(E)-Amino(imino)methyl]-1H-benzimidazol-2-yl}oxy)phenyl]-1H-benzimidazole-5-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102002; BDBM50027302
Click to Show/Hide
|
||||
| Activity |
Ki ~ 200000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 224 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amiloride
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
Argatroban
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Acova; Argatrobanum; MMTQAP; MPQA; Novastan; Argatrobanum [Latin]; MITSUBISHI INHIBITOR; MCI 9038; MD 805; MD805; Argatroban (anhydrous); Argatroban [INN:JAN]; GN-1600; MCI-9038; MD-805; MQI-ARG-MCP; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-4-Methyl-1-((S)-N(sup 2)-(((RS)-1,2,3,4-tetrahydro-3-methyl-8-quinolyl)sulfonyl)arginyl)pipecolic acid; (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl)]-2-piperadinecarboxylic acid; (2r,4r)-4-methyl-1-[n2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-l-arginyl]-2-piperidinecarboxylic acid; 21R-Argatroban; 4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 257000 nM
|
[63] | |||
| Compound Name |
Dalfampridine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Ampyra (TN)
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[64] | |||
| Compound Name |
Benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzamidine; Benzimidamide; Benzenecarboximidamide; 618-39-3; Phenylamidine; UNII-KUE3ZY3J1F; NSC 243704; CCRIS 2952; Benzamidine (Protonated); EINECS 210-546-3; KUE3ZY3J1F; CHEMBL20936; CHEBI:41033; PXXJHWLDUBFPOL-UHFFFAOYSA-N; BDN; 1oss; 2ast; 1bra; Benzenecarboxamidine; 1v2m; 1v2j; 1h4w; 1ce5; 1c5o; 2j9n; 1f5k; 1c5p; 1v2v; 1v2s; 1v2l; 1c5z; 1v2u; AC1L1DFX; Lopac-B-6506; ACMC-1B9LG; SCHEMBL9207; Lopac0_000203; MLS001066369; GTPL7566; AC1Q1U98; DTXSID8045012; 1670-14-0 (hydrochloride); ZINC36634; CTK2F5055; 1w80; 1j16; 1j15; MolPort-000-001-395
Click to Show/Hide
|
||||
| Activity |
Ki = 350000 nM
|
[64] | |||
| Compound Name |
4-(5-Nitro-indol-1-ylmethyl)-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100296; 4-(5-Nitro-indol-1-ylmethyl)-benzamidine
Click to Show/Hide
|
||||
| Activity |
Ki > 400000 nM
|
[3] | |||
| Compound Name |
1-Benzyl-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101343; 1-Benzyl-1H-indole-5-carboxamidine; BDBM50027286
Click to Show/Hide
|
||||
| Activity |
Ki = 844000 nM
|
[3] | |||
| Compound Name |
(4-guanidino-benzyl)-carbamic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391969; (4-guanidino-benzyl)-carbamic acid benzyl ester
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[18] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(naphthalen-2-ylsulfonylamino)pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415479; BDBM50076724
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[65] | |||
| Compound Name |
2-Chloro-benzenesulfonic acid 3-(3-guanidino-propoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291062; BDBM50070598
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
(2S)-N-Cyclopentyl-2-[(6-methoxynaphthalen-2-yl)sulfonylamino]-N-methyl-5-[4-(methylamino)phenyl]pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7758; BDBM50076725
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[65] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-[(4-propylphenyl)sulfonylamino]pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553108; BDBM50076730
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[65] | |||
| Compound Name |
2-Chlorobenzenesulfonic acid 3-methyl-5-(1-amidinopiperidine-4-ylmethoxy)phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41876; SCHEMBL7446067; BDBM50070597; 2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-4-ylmethoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
3-(6-Chloronaphthalen-2-yl)sulfonyl-N-methyl-N-[1-(2-methylpyridin-4-yl)piperidin-4-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261646; SCHEMBL7013757; BDBM50372526
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[67] | |||
| Compound Name |
2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-3-ylmethoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41862; SCHEMBL7440084; BDBM50070600
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[2-oxo-3-(pyridin-4-ylmethyl)-1,3-benzoxazol-6-yl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585741; BDBM50093546
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[3-[3-(2-methylpropyl)-2-oxo-1,3-benzoxazol-6-yl]-2,5-dioxoimidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585740; BDBM50093547
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
3-Benzoyl-1H-indole-6-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102009; BDBM50027289; ZINC26745044
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[3] | |||
| Compound Name |
2-Chlorobenzenesulfonic acid 3-methyl-5-(4-guanidinobutoxy)phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287807; BDBM50070599; 2-Chloro-benzenesulfonic acid 3-(4-guanidino-butoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-5-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-1,3-benzoxazole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585743; BDBM50093545
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
2-Chlorophenyl[3-[2-[methyl(4-pyridyl)amino]ethoxy]-5-methylphenoxy] sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289951; SCHEMBL8545290; BDBM50064653; [3-methyl-5-[2-[methyl(pyridin-4-yl)amino]ethoxy]phenyl] 2-chlorobenzenesulfonate; 2-Chloro-benzenesulfonic acid 3-methyl-5-[2-(methyl-pyridin-4-yl-amino)-ethoxy]-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-2-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-1-methylbenzimidazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585747; BDBM50093543
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
(13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883461; BDBM50210073
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[68] | |||
| Compound Name |
2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287910; BDBM50070595
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[66] | |||
| Compound Name |
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)pent-4-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7587; BDBM50076722
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[65] | |||
| Compound Name |
(8e)-3-Amino-1-Methyl-15-[(1h-Pyrazol-1-Yl)methyl]-7,10,11,12,24,25-Hexahydro-6h,18h,23h-19,22-(Metheno)pyrido[4,3-J][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884851; BDBM50210127; GBT
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[68] | |||
| Compound Name |
3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64578; BDBM50115893; N-(4-Guanidinophenyl)-2-hydroxy-3-bromo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 205000 nM
|
[16] | |||
| Compound Name |
(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350657; BDBM50110013; Boc-L-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki = 210000 nM
|
[19] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238367; BDBM50009176
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[11] | |||
| Compound Name |
2-[4-[(3,3-Dimethyl-2,4-dihydro-1H-quinolin-8-yl)sulfonylamino]-5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-oxopentyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448420; BDBM50082580
Click to Show/Hide
|
||||
| Activity |
Ki = 210000 nM
|
[69] | |||
| Compound Name |
CGH-1484A free base
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-620VW8H64Y; CHEMBL263806; 620VW8H64Y; BDBM50090238; Q27263411
Click to Show/Hide
|
||||
| Activity |
Ki = 212000 nM
|
[70] | |||
| Compound Name |
1,4-Bis[methyl[1,4-dioxo-4-[4-(aminomethyl)benzylamino]butyl]aminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79822; BDBM50093133
Click to Show/Hide
|
||||
| Activity |
Ki = 214000 nM
|
[39] | |||
| Compound Name |
2-[3-(Phenylethynyl)-5-chloro-2-pyridinyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300030; BDBM50108371; N-(5-Chloro-3-phenylethynyl-pyridin-2-yl)-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 218000 nM
|
[71] | |||
| Compound Name |
Tert-butyl 3-[3-[5-[[(1S)-5-amino-1-cyanopentyl]carbamoyl]-2-(pyridin-4-ylmethoxy)anilino]-3-oxopropyl]indole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910640; BDBM50355958
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[36] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(3-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238368; BDBM50009177
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[11] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-2-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910638; BDBM50355956
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[36] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238370; BDBM50009179
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[11] | |||
| Compound Name |
1,4-Bis[methyl[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80210; BDBM50093131
Click to Show/Hide
|
||||
| Activity |
Ki > 230000 nM
|
[39] | |||
| Compound Name |
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[6-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]pyridin-2-yl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076224; BDBM50260053
Click to Show/Hide
|
||||
| Activity |
IC50 = 231000 nM
|
[32] | |||
| Compound Name |
N-(5-Bromo-isoquinolin-1-yl)-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110358; Guanidine, N-(5-bromo-1-isoquinolinyl)-; BDBM50147428
Click to Show/Hide
|
||||
| Activity |
Ki = 237800 nM
|
[9] | |||
| Compound Name |
Methyl 3-(2-methyl-1-oxopropoxy)(1)benzothieno(3,2-b)furan-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
LY 806303; CHEMBL268367; Methyl 3-(isobutyryloxy)benzo[4,5]thieno[3,2-b]furan-2-carboxylate; ACMC-20n5t0; Oprea1_823161; L-806303; CTK4C6335; DTXSID10933714; BDBM50280655; LY-806303; Methyl 3-[(2-methylpropanoyl)oxy][1]benzothieno[3,2-b]furan-2-carboxylate; 3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-carboxylic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[72] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910423; BDBM50355954
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[36] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39375; BDBM50090231
Click to Show/Hide
|
||||
| Activity |
Ki = 240000 nM
|
[53] | |||
| Compound Name |
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AEBSF HCl; AEBSF hydrochloride; AEBSF; Pefabloc SC; AEBSF (hydrochloride); AEBSF, Hydrochloride; MFCD00132962; 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride; 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochloride; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride; AEBSF.HCl; 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride; 30827-99-7 (HCl); Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1); AEBSF hydrochloride, 98%; 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride; 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; Benzenesulfonylfluoride, 4-(2-aminoethyl)-, hydrochloride (1:1); CHEMBL1256178; SR-01000075690; AEBSF-hydrochloride; PubChem14462; EU-0100132; ACMC-1CTY2; 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl; SCHEMBL25973; MLS002153464; AEBSF HCl Biochemistry grade; CTK1C4244; KS-00000VYT; DTXSID60184830; BCP32155; EX-A2487; Tox21_500132; ANW-43152; NSC727364; PC5642; Pefabloc(R) SC, analytical standard; s7378; SBB003219; AKOS015847774; CCG-207883; FS-5456; LP00132; NSC-727364; VZ27664; NCGC00093623-01; NCGC00260817-01; AK-82709; HY-12821; QC-10428; SMR001230821; SY007034; 4-(2-Aminoethyl)benzenesulfonylfluoride HCl; AB0014776; DB-047913; 2-AMINOETHYLPHENYLSULFONEHYDROCHLORIDE; FT-0616512; SW219355-1; 4-(2-Aminoethyl)Benzenesulfonyl Fluoride HCl; AEBSF Ready Made Solution, 100 mM in water; 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl; A 8456; A14270; K-7365; M01245; P-1195; [4-(2-aminoethyl)phenyl]fluorosulfone, chloride; Pefabloc, Antibiotic for Culture Media Use Only; 827A997; 4-(2-Aminoethyl)benzenesulfonylfluoridehydrochloride; SR-01000075690-1; 4-(2-aminoethyl)-benzenesulfonylfluoride hydrochloride; 4-(2-aminoethyl)benzenesulfonyl fluoride,hydrochloride; Benzenesulfonyl fluoride, p-(2-aminoethyl)-, hydrochloride; Pefabloc(R) SC, certified reference material, TraceCERT(R); 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, >=97%
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[43] | |||
| Compound Name |
(S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-amino)-acetyl]-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441468; BDBM50066331; N-(2,5-Dichlorobenzyl)-1-[(R)-N-[(diethylcarbamoyl)methyl]-2-cyclohexylglycyl]-L-prolinamide
Click to Show/Hide
|
||||
| Activity |
Ki = 244000 nM
|
[55] | |||
| Compound Name |
2-(5-Methylpyridin-2-yl)guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53031; SCHEMBL6440277; 2-(5-Methyl-2-pyridinyl)guanidine; BDBM50108365; ZINC13436477; N-(5-Methyl-pyridin-2-yl)-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 245000 nM
|
[62] | |||
| Compound Name |
2-[[6-Amino-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013180; BDBM50379654
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(2-oxopropoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238371; BDBM50009188
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[11] | |||
| Compound Name |
Benzyl 2-[[6-amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013178; BDBM50379655
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
Benzyl 2-[(6-amino-5-carbamoyl-3-chloropyrazin-2-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013184; BDBM50379659
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
2-[(6-Amino-5-carbamimidoylpyrazin-2-yl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013183; BDBM50379658
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
2-[[6-Amino-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013186; BDBM50379662
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
Benzyl 2-[[6-amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013185; BDBM50379660
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[5-oxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233152; BDBM50009209
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[11] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-quinolin-6-yloxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238377; BDBM50009203
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[11] | |||
| Compound Name |
Benzyl 2-[(6-amino-5-carbamimidoyl-3-chloropyrazin-2-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013181; BDBM50379656
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
2-[[6-Amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1962712; CHEMBL1909781; SCHEMBL10087509; BDBM50356121
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
[1-[(Benzyloxycarbonyl)amino]-4-aminobutyl]phosphonic acid diphenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9971041; CHEMBL1179439
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[73] | |||
| Compound Name |
2-[[6-Amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2013179; BDBM50379663
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[58] | |||
| Compound Name |
3,5-Dimethylbenzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,5-Dimethylbenzamidine; CHEMBL3247192; 3,5-DIMETHYL-BENZAMIDINE; Benzenecarboximidamide, 3,5-dimethyl-; 3,5-Dimethylbenzimidamide; SCHEMBL21792281; CTK4F7120; DTXSID90391752; ZINC1437802; BDBM50010256; Benzenecarboximidamide,3,5-dimethyl-; AKOS010915560; SC-40633
Click to Show/Hide
|
||||
| Activity |
Ki = 251188.64 nM
|
[27] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238365; BDBM50009174
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[11] | |||
| Compound Name |
(Alphae)-2-(Diaminomethyleneamino)-5-chloropyridine-3-acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294255; BDBM50108372; (E)-3-(5-Chloro-2-guanidino-pyridin-3-yl)-acrylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 278500 nM
|
[71] | |||
| Compound Name |
1-{4-[4-Amino(imino)methylphenylcarboxamidomethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42899; BDBM50101015
Click to Show/Hide
|
||||
| Activity |
Ki = 279000 nM
|
[26] | |||
| Compound Name |
Tetrasodium;[4-[4-oxo-5-[4-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxybutoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060094; BDBM50260056
Click to Show/Hide
|
||||
| Activity |
IC50 = 282000 nM
|
[32] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64740; BDBM50115891
Click to Show/Hide
|
||||
| Activity |
Ki = 283000 nM
|
[16] | |||
| Compound Name |
1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40491; BDBM50101019
Click to Show/Hide
|
||||
| Activity |
Ki = 287000 nM
|
[26] | |||
| Compound Name |
(2S)-6-Amino-2-[[(2S)-2-[[(2R,3R)-2-amino-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910422; BDBM50355953
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[36] | |||
| Compound Name |
1-{4-[4-Amino(imino)methylphenylcarbamoylmethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295007; BDBM50101022
Click to Show/Hide
|
||||
| Activity |
Ki = 293000 nM
|
[26] | |||
| Compound Name |
1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42898; BDBM50101016
Click to Show/Hide
|
||||
| Activity |
Ki = 310000 nM
|
[26] | |||
| Compound Name |
1,6-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,6-hexanedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307427; SCHEMBL7506036; BDBM50093170
Click to Show/Hide
|
||||
| Activity |
Ki = 316000 nM
|
[22] | |||
| Compound Name |
3-Phenylbenzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BIPHENYL-3-CARBOXAMIDINE; CHEMBL3247187; [1,1'-Biphenyl]-3-carboximidamide; 1,1'-Biphenyl-3-carboxamidine; SCHEMBL14676446; CTK1A1588; 3-phenylbenzene-1-carboximidamide; DTXSID30393699; ZINC1437951; BDBM50010252; AKOS006293461
Click to Show/Hide
|
||||
| Activity |
Ki = 316227.77 nM
|
[27] | |||
| Compound Name |
2-Methyl-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Methylbenzimidamide; 2-Methylbenzenecarboximidamide; 2-methylbenzamidine; CHEMBL3247182; o-Toluamidine; methyl-benzamidine; Benzamidine, 2-methyl-; SCHEMBL3368840; 2-Methylbenzenecarboximidamide #; Benzenecarboximidamide,2-methyl-; CTK4D9222; DTXSID00341884; ZINC1439402; 1807AJ; BDBM50010245; MFCD05663318; AKOS000184773; MCULE-3830416568; NE62768; SB34636; SC-40472; FT-0740244
Click to Show/Hide
|
||||
| Activity |
Ki = 316227.77 nM
|
[27] | |||
| Compound Name |
3-Methoxy-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Methoxybenzimidamide; 3-methoxybenzenecarboximidamide; 3-Methoxybenzamidine; CHEMBL3247189; Benzenecarboximidamide,3-methoxy-; 5-methoxybenzamidine; 3-methoxybenzenecarboxamidine; SCHEMBL428920; CTK4F5694; DTXSID00408426; 3-methoxybenzene-1-carboximidamide; Benzenecarboximidamide, 3-methoxy-; ZINC1439405; 2322AJ; BDBM50010253; STL253522; AKOS000168993; MCULE-9305717157; NE62873; SB36205; AK137713; DA-17011; BB 0238635; FT-0716825; ST45243326; Z-8586
Click to Show/Hide
|
||||
| Activity |
Ki = 316227.77 nM
|
[27] | |||
| Compound Name |
1beta-[[4-(4-Amidinobenzoylaminomethyl)piperidino]carbonyloxy]-5beta-[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295450; BDBM50101023
Click to Show/Hide
|
||||
| Activity |
Ki = 320000 nM
|
[26] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-propylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238364; BDBM50009173
Click to Show/Hide
|
||||
| Activity |
IC50 = 330000 nM
|
[11] | |||
| Compound Name |
2-Phenyl-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96917; SCHEMBL14599542; BDBM50100891; ZINC12354847; 2-Phenyl-1H-benzoimidazole-5-carboxamidine; 2-Phenyl-3H-benzoimidazole-5-carboxamidine; 2-phenyl-3H-benzimidazole-5-carboximidamide
Click to Show/Hide
|
||||
| Activity |
Ki = 350000 nM
|
[23] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[3-(1H-indol-3-yl)propanoylamino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910641; BDBM50355959
Click to Show/Hide
|
||||
| Activity |
IC50 = 370000 nM
|
[36] | |||
| Compound Name |
3-Carbamimidoylbenzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-4HDD4R2AEW; 4HDD4R2AEW; CHEMBL3247184; 3-CARBAMIMIDOYL-BENZOIC ACID; 3-amidinobenzoic acid; Ataluren metabolite M2; SCHEMBL431391; 3-(aminoiminomethyl)benzoic acid; CTK7D1934; DTXSID00962715; ZINC4202678; BDBM50010247; AKOS006276125; Cyclopentanecarboxylicacid, 2-hydroxy-, methyl ester, (1R,2S)-rel-
Click to Show/Hide
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||||
| Activity |
Ki = 398107.17 nM
|
[27] | |||
| Compound Name |
3-[Bis(6-aminohexyl)amino]tetrahydro-4H-thiopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318854; BDBM50079380; 3-[Bis-(6-amino-hexyl)-amino]-tetrahydro-thiopyran-4-one
Click to Show/Hide
|
||||
| Activity |
Ki = 400000 nM
|
[8] | |||
| Compound Name |
2-[(E)-1-[3-(Benzenesulfonamido)-5-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]ethylideneamino]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644912; BDBM50333192
Click to Show/Hide
|
||||
| Activity |
Ki = 400000 nM
|
[54] | |||
| Compound Name |
1H-Indole-5-carboximidamide, 1-ethyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322894; 1-Ethyl-1H-indole-5-carboxamidine; BDBM50027294
Click to Show/Hide
|
||||
| Activity |
Ki > 400000 nM
|
[3] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-amino-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238372; BDBM50009197
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[11] | |||
| Compound Name |
{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320407; BDBM50046369
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[41] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)acetyl]pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555753
Click to Show/Hide
|
||||
| Activity |
Ki = 414000 nM
|
[61] | |||
| Compound Name |
2-((R)-3-{(R)-3-[(S)-2-((S)-Benzyloxycarbonylamino)-3-phenyl-propionylamino]-2-oxo-cyclohexyl}-propionylamino)-3-(1H-indol-3-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127196; BDBM50081424
Click to Show/Hide
|
||||
| Activity |
Ki = 420000 nM
|
[47] | |||
| Compound Name |
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1H-indole-2-carbonyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108848; BDBM50046354; 1-(1H-Indole-2-carbonyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 420000 nM
|
[41] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(1R)-1,2,3,4-tetrahydroisoquinoline-1-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370421; BDBM50046370
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[41] | |||
| Compound Name |
3-[4-(Guanidinomethyl)phenyl]-6-methylenetetrahydro-2H-pyran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335908; BDBM50003742; N-[4-(6-Methylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine; (Lactone1)N-[4-(6-Methylene-2-oxo-tetrahydro-pyran-3-yl)-benzyl]-guanidine
Click to Show/Hide
|
||||
| Activity |
Ki = 466000 nM
|
[74] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46809; APC-1390; SCHEMBL7415218; BDBM50093142; BDBM50218667; 1beta,5beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane; 1,5-di{4-[4-amino(imino)methylaminobenzylcarbamoyl]hexahydro-1-pyrazinylcarbonyloxy}cyclooctane
Click to Show/Hide
|
||||
| Activity |
Ki = 494000 nM
|
[22] | |||
| Compound Name |
Pyridin-4-yl-(2-m-tolyloxy-ethyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23243; BDBM50289379; AKOS006022403
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
2-(Naphthalene-2-sulfonylamino)-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25835; BDBM50289376
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
N-(2-Phenoxyethyl)pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL285311; SCHEMBL6672805; BDBM50289374; ZINC28754772; AKOS010879683; (2-Phenoxy-ethyl)-pyridin-4-yl-amine; MCULE-7251389328; Z1317598163
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
N-[3-[2-(Pyridin-4-ylamino)ethoxy]phenyl]naphthalene-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23246; SCHEMBL8544836; BDBM50289381; Naphthalene-2-sulfonic acid {3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-amide
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
N-Methyl-N-[3-[2-(pyridin-4-ylamino)ethoxy]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282549; SCHEMBL8547694; BDBM50070596; N-Methyl-N-{3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
2-(4-Chloro-benzenesulfonylamino)-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23468; BDBM50289373
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
4-Chloro-N-(2-{3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-ethyl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25890; SCHEMBL9128291; BDBM50289382; N-[3-[2-(4-Pyridinylamino)ethoxy]phenethyl]-4-chlorobenzenesulfonamide; 4-chloro-N-[2-[3-[2-(pyridin-4-ylamino)ethoxy]phenyl]ethyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
4-Chloro-N-{3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23252; BDBM50126700; 4-chloro-N-[3-[2-(pyridin-4-ylamino)ethoxy]phenyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
4-[2-(3-Benzenesulfonylamino-phenoxy)-ethylamino]-pyridinium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23813; SCHEMBL8543078; BDBM50070632; N-[3-[2-(pyridin-4-ylamino)ethoxy]phenyl]benzenesulfonamide; N-{3-[2-(Pyridin-4-ylamino)-ethoxy]-phenyl}-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
4-(2-Hydroxyethylamino)-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-4-ylamino)ethanol; 2-[(pyridin-4-yl)amino]ethan-1-ol; CHEMBL24479; Ethanol,2-(4-pyridinylamino)-; MFCD08437502; 2-(pyridin-4-ylamino)ethan-1-ol; SCHEMBL714498; 2-(Pyridin-4-ylamino)-ethanol; 4-(2-hydroxyethylamino)pyridine; 2-(N-(4-pyridyl)amino)ethanol; CTK4E0898; DTXSID50590466; Ethanol, 2-(4-pyridinylamino)-; 4-((2-Hydroxyethyl)amino)pyridine; BDBM50289380; ZINC15443514; AKOS009227756; NE31100; DB-017135; FT-0749067; EN300-66163; A803703; Z1741967608
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23300; BDBM50289378
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
2-Benzenesulfonylamino-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281715; BDBM50289375
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[64] | |||
| Compound Name |
Benzamidine hydrochloride hydrate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzenecarboximidamide hydrochloride hydrate; benzamidine hydrate hydrochloride; Benzamidinehydrochloridehydrate; Benzamidinium chloride; benzamidine hydrochloride monohydrate; MFCD00066285; Amidinobenzene hydrochloride; benzenecarboximidamide;hydrate;hydrochloride; Benzamidine hydrochloride hydrate, 98%; Benzamidine hydrochloride, 99%; SMR000326732; Benzamidine HCl hydrate; ACMC-20a6bw; BENZAMIDINE HYDROCHLORIDE MONOHYDRATE 99+%; KSC491M3D; MLS000859669; MLS001056775; benzamidin hydrochloride hydrate; CHEMBL1528282; CTK3J1631; Benzenecarboximidamide HCl hydrate; DTXSID70585091; Benzimidamide hydrochloride hydrate; KS-00000EM9; STR01054; ANW-59130; SBB055167; benzimidamide hydrochloride monohydrate; AKOS015889025; benzenecarboxamidine, chloride, hydrate; AC-4789; PS-8610; AK-48017; Benzamidine hydrochloride hydrate, >=99%; SC-05937; SY018319; benzenecarboximidamide hydrate hydrochloride; AB0061775; AM20030117; FT-0622633; FT-0695723; B-0500; Z-4439; Benzenecarboximidamide, hydrochloride, hydrate (1:1:); F0001-0736
Click to Show/Hide
|
||||
| Activity |
Ki = 501187.23 nM
|
[27] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-5-oxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233151; BDBM50009208
Click to Show/Hide
|
||||
| Activity |
IC50 = 510000 nM
|
[11] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoyl-4-phenoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238379; BDBM50009205
Click to Show/Hide
|
||||
| Activity |
IC50 = 510000 nM
|
[11] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-1-[6-aminohexyl(cyclohexyl)amino]-1-oxo-3-phenylpropan-2-yl]-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101236; BDBM50079383
Click to Show/Hide
|
||||
| Activity |
Ki = 520000 nM
|
[8] | |||
| Compound Name |
[5-[4-[2-[4-(2-Aminoethyl)phenyl]ethylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-[4-(2-aminoethyl)phenyl]ethylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307597; BDBM50093179
Click to Show/Hide
|
||||
| Activity |
Ki = 570000 nM
|
[22] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-1-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910639; BDBM50355957
Click to Show/Hide
|
||||
| Activity |
IC50 = 570000 nM
|
[36] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[3-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330791
Click to Show/Hide
|
||||
| Activity |
Ki = 572000 nM
|
[61] | |||
| Compound Name |
1,3-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]adamantane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78283; BDBM50093196
Click to Show/Hide
|
||||
| Activity |
Ki = 576000 nM
|
[22] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-3-[[2-(4-fluorophenyl)acetyl]amino]-4-(pyridin-4-ylmethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910424; BDBM50355955
Click to Show/Hide
|
||||
| Activity |
IC50 = 590000 nM
|
[36] | |||
| Compound Name |
(4-{2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-3-phenyl-propionylamino}-phenyl)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3084799; BDBM50092337; [4-[[1-Oxo-2-[[4-(aminomethyl)cyclohexyl]carbonylamino]-3-phenylpropyl]amino]phenyl]acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 620000 nM
|
[75] | |||
| Compound Name |
4-(Hydroxymethyl)benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Hydroxymethyl-benzamidine; CHEMBL184048; 4-(hydroxymethyl)benzenecarboximidamide; SCHEMBL1587086; CTK1J2205; DTXSID30332280; ZINC6535656; BDBM50153443; AKOS009343458; DB02585; SC-40280; Benzenecarboximidamide, 4-(hydroxymethyl)-; Q27093558
Click to Show/Hide
|
||||
| Activity |
Ki = 630957.34 nM
|
[27] | |||
| Compound Name |
1beta,5beta-Bis[4-[2-(1-amidino-4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77043; SCHEMBL7425638; BDBM50093181
Click to Show/Hide
|
||||
| Activity |
Ki = 632000 nM
|
[22] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1,2,3,4-tetrahydroquinoline-2-carbonyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370422; BDBM50046357
Click to Show/Hide
|
||||
| Activity |
IC50 = 660000 nM
|
[41] | |||
| Compound Name |
(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42495; BDBM50066336; (S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide
Click to Show/Hide
|
||||
| Activity |
Ki = 691000 nM
|
[55] | |||
| Compound Name |
(3Aalpha,6aalpha)-3beta,6beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]hexahydrofuro[3,2-b]furan
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306620; apc2059; BDBM50093153
Click to Show/Hide
|
||||
| Activity |
Ki = 700000 nM
|
[22] | |||
| Compound Name |
1-(4-Carbamimidoyl-2-chloro-benzyl)-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102141; BDBM50027287
Click to Show/Hide
|
||||
| Activity |
Ki > 700000 nM
|
[3] | |||
| Compound Name |
[(2S,3S)-3-[[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxymethyl]-2-bicyclo[2.2.2]oct-5-enyl]methyl 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77007; BDBM50093182
Click to Show/Hide
|
||||
| Activity |
Ki = 700000 nM
|
[22] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343518; BDBM50029503
Click to Show/Hide
|
||||
| Activity |
IC50 = 740000 nM
|
[76] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122894
Click to Show/Hide
|
||||
| Activity |
Ki = 744000 nM
|
[61] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431675
Click to Show/Hide
|
||||
| Activity |
Ki = 744000 nM
|
[61] | |||
| Compound Name |
1,4-Bis[1,4-dioxo-4-[4-(aminomethyl)benzylamino]butylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76733; BDBM50093143
Click to Show/Hide
|
||||
| Activity |
Ki = 769000 nM
|
[39] | |||
| Compound Name |
(2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(2S)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336471; BDBM50029505
Click to Show/Hide
|
||||
| Activity |
IC50 = 850000 nM
|
[76] | |||
| Compound Name |
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-methoxy-2-phenylacetyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107598; BDBM50046371; 1-(2-Methoxy-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 860000 nM
|
[41] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-4-(4-phenoxyphenyl)piperazin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233153; BDBM50009210
Click to Show/Hide
|
||||
| Activity |
IC50 = 960000 nM
|
[11] | |||
| Compound Name |
1,10-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,10-decanedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76883; SCHEMBL7570914; BDBM50093178
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[Methyl(2-piperidin-4-ylethyl)carbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406737; BDBM50093200
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(4-guanidinophenylacetyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309830; SCHEMBL7422920; BDBM50093173
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(5-aminopentylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42900; SCHEMBL7421769; SCHEMBL7950272; BDBM50093158; BDBM50218668
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-[4alpha-(aminomethyl)cyclohexane-1beta-ylmethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263454; SCHEMBL7420561; BDBM50093160
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80878; BDBM50093152
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[1,4-dioxo-4-[methyl[4-(aminomethyl)benzyl]amino]butylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78757; BDBM50093138
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
1beta,5beta-Bis[4-[3-(4-guanidinophenyl)propionyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306622; SCHEMBL7426287; BDBM50093166
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[1,5-dioxo-5-[4-(aminomethyl)benzylamino]pentylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306537; BDBM50093141
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
Mupain-1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734777; BDBM50499239
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[77] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78173; BDBM50093188
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-methylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77361; BDBM50093149
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160944; BDBM50110018
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
4-Amino-4-{[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371217; L-Glu-Gly-(4-Amidinobenzyl)NH2; BDBM50110011
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
1beta-[[4-(4-Amidinophenylacetyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38054; BDBM50101017
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
1,4-Bis[1,4-dioxo-4-(4-guanidinobenzylamino)butylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309788; BDBM50093136
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
N-[(6-Amino-2-methylpyridin-3-yl)methyl]-1-[[4-(pyrazol-1-ylmethyl)phenyl]methyl]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884830; BDBM50210072
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[68] | |||
| Compound Name |
1,8-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,8-octanedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311655; SCHEMBL7504794; BDBM50093175
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-11-(carboxymethyl)-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735080; BDBM50499240
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[77] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(6-aminopyridin-3-yl)propanoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310412; BDBM50093177
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
3-[2-Amino-3-(4-methanesulfonyl-piperazin-1-yl)-3-oxo-propyl]-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL411506; BDBM50060020
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[15] | |||
| Compound Name |
1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylaminomethyl]piperidino]carbonyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296733; BDBM50101021
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
2-Acetylamino-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349545; BDBM50110021; Ac-D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
1beta,5beta-Bis[4-[4-(aminomethyl)benzylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431969; SCHEMBL7469000; BDBM50093157
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
Tetrasodium;[4-[4-oxo-5-[3-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxypropoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088333; BDBM50260055
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[32] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332870
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[61] | |||
| Compound Name |
1-Methyl-1h-indole-5-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101878; SCHEMBL1817590; 1-Methyl-1H-indole-5-carboxamidine; BDBM50027300; 1-METHYLINDOLE-5-CARBOXIMIDAMIDE
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
[5-[4-[[4-(Aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312023; BDBM50093180
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
4-Tert-Butoxycarbonylamino-4-{[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160580; BDBM50110007
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
1beta,5beta-Bis[3-(4-guanidinobenzyl)ureidoacetoxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75749; BDBM50093132
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-piperidin-4-ylpropylcarbamoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77998; BDBM50093194
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
3-Hydroxy-N-{[4-(N-hydroxycarbamimidoyl)-benzylcarbamoyl]-methyl}-2-phenylmethanesulfonylamino-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157479; BDBM50110009
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
3-Nitrobenzamidine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
m-Nitrobenzamidine hydrochloride; 3-NITROBENZENE-1-CARBOXIMIDAMIDE HYDROCHLORIDE; 3-Nitrobenzenecarboximidamide hydrochloride; 3-Nitrobenzimidamide hydrochloride; 3-nitrobenzenecarboximidamide;hydrochloride; ACMC-1AWL2; SCHEMBL1262882; CHEMBL3350788; 3-nitro-benzamidine hydrochloride; CTK8C5933; KS-00001KOC; DTXSID00971847; 3-nitrobenzenecarboxamidine, chloride; MFCD00012844; NSC310196; AKOS008090187; AKOS015889236; 3-Nitrobenzamidine hydrochloride, 95%; AB01110; CD-0706; MCULE-5916113905; NE10715; NSC-310196; BP-12505; SC-41158; DB-052910; FT-0640382; ST51006852; F1905-7011; 3-Nitrobenzene-1-carboximidamide--hydrogen chloride (1/1)
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[27] | |||
| Compound Name |
1,4-Bis[[2-oxo-2-(1-amidino-4-piperidinylmethylamino)ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297408; BDBM50101014
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-4-guanidinobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644915; BDBM50333191
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[54] | |||
| Compound Name |
1beta,5beta-Bis[4-(6-aminohexylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307927; SCHEMBL7421921; BDBM50093203
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-imidazol-1-ylbutanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76967; BDBM50093150
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43463; BDBM50093140
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-[(E)-N'-Methoxycarbonylcarbamimidoyl]phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42364; BDBM50101020
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
1beta,5beta-Bis[4-[2-[1-(1-iminoethyl)-4-piperidinyl]ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77326; BDBM50093201
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(4-aminobutylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77183; SCHEMBL7426001; BDBM50093159
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77182; CHEMBL308763; BDBM50093176; BDBM50093193
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-6-guanidinohexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644916; BDBM50333197
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[54] | |||
| Compound Name |
1beta,5beta-Bis[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75624; SCHEMBL7446733; BDBM50093171
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(1-amidino-4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77949; SCHEMBL7962399; BDBM50093162
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(1-amidino-4-piperidinylacetyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75635; SCHEMBL7958531; BDBM50093168
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-3-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333238
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[61] | |||
| Compound Name |
1beta,5beta-Bis[4-[3-(1-amidino-4-piperidinyl)propionyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76424; SCHEMBL7420671; BDBM50093186
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
Vaborbactam
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RPX-7009; RPX7009; UNII-1C75676F8V; CHEMBL3317857; 1C75676F8V; Vaborbactam [INN]; RPX 7009; Vaborbactam. RPX7009; Vaborbactam (USAN/INN); Vaborbactam [USAN:INN]; SCHEMBL620289; GTPL10871; Vabomere (vaborbactam + meropenem); EX-A2589; BDBM50089084; MFCD28502176; AKOS032961376; CS-6445; DB12107; SB17184; compound 9f [PMID: 25782055]; NCGC00510003-01; HY-19930; D10998; Q27252228
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[78] | |||
| Compound Name |
1beta,5beta-Bis[4-[1-(1-iminoethyl)-4-piperidinylmethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309395; BDBM50093174
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobutylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80930; SCHEMBL7422418; SCHEMBL7964955; BDBM50093148
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-pyridin-4-ylethylcarbamoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263244; BDBM50093172
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311043; BDBM50093198
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,7-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,7-heptanedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76796; SCHEMBL7508800; BDBM50093183
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1H-Indole-6-carboximidamide, 3-(2,2,2-trifluoroacetyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415700; BDBM50027292; 3-(2,2,2-Trifluoro-acetyl)-1H-indole-6-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
(2R)-2-Amino-N-[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]-5-(diaminomethylideneamino)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644913; BDBM50333195; (R)-2-amino-N-(3,5-bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-5-guanidinopentanamide
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[54] | |||
| Compound Name |
1,9-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,9-nonanedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75972; SCHEMBL7499097; BDBM50093199
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310290; BDBM50084616
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
1,4-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75750; BDBM50093167
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylamino]butyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289918; BDBM50101012
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(5-imidazol-1-ylpentanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80502; BDBM50093195
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(3-aminopropylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307637; SCHEMBL7428254; SCHEMBL7962495; BDBM50093202
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(2-aminopyrimidin-5-yl)propanoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77074; BDBM50093165
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79655; BDBM50093134
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
(S)-N-((1-Carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568067; BDBM50303778
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[42] | |||
| Compound Name |
1,4-Bis[1,3-dioxo-3-[4-(aminomethyl)benzylamino]propylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77521; BDBM50093146
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
3-(3-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133027; BDBM50067523; 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(3-carbamimidoyl-phenyl)-propionic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[12] | |||
| Compound Name |
[5-[4-(6-Imidazol-1-ylhexanoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(6-imidazol-1-ylhexanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76070; BDBM50093155
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-[4-(methylaminomethyl)benzylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307479; BDBM50093189
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-piperidin-4-ylbutanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308630; BDBM50093161
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[1,5-dioxo-5-(4-guanidinobenzylamino)pentylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79545; BDBM50093147
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(6-imidazol-1-ylhexanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263557; BDBM50093191
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1beta,5beta-Bis[4-(5-aminopentylcarbamoyl)piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308764; SCHEMBL7424637; BDBM50093190
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[[2-oxo-2-[2-(1-amidino-4-piperidinyl)ethylamino]ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406192; BDBM50101013
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
1-{4-[4-Amino(imino)methylphenylsulfonamidomethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42037; BDBM50101024
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[26] | |||
| Compound Name |
1alpha,4beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]cyclohexane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308632; SCHEMBL7421119; BDBM50093164
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[1,3-dioxo-3-(4-guanidinobenzylamino)propylaminomethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46120; BDBM50093144
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
1,4-Bis[[2-oxo-2-(4-guanidinobenzylamino)ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77911; BDBM50093135
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-5-guanidinopentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644914; BDBM50333196
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[54] | |||
| Compound Name |
1beta,5beta-Bis[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307374; BDBM50093151
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1,4-Bis[[(R)-1-methyl-2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310289; BDBM50093139
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[(3-methyl-2,5-dioxoimidazolidin-1-yl)methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238361; BDBM50009170
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135198; BDBM50067530
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[12] | |||
| Compound Name |
1beta,5beta-Bis[4-[4-(2-aminoethyl)phenylacetyl]piperazinocarbonyloxy]cyclooctane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75679; SCHEMBL7415237; BDBM50093197
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
Boc-D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440919; BDBM50110004
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
1,4-Bis[[3-oxo-3-(4-guanidinobenzylamino)propyl]carbamoyloxymethyl]benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408300; BDBM50093145
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[39] | |||
| Compound Name |
(3Aalpha,6aalpha)-2beta,5beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]octahydropentalene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308074; BDBM50093184
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
1H-Indole-6-carboximidamide, 3-acetyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321524; 3-Acetyl-1H-indole-6-carboxamidine; BDBM50027283
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
2-Amino-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345236; L-Ser-Gly-(4-Amidinobenzyl)NH2; BDBM50110017
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(pyridin-4-ylamino)propanoyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312463; BDBM50093169
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-pyridin-4-ylsulfanylpropanoyl)piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306258; BDBM50093163
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[22] | |||
| Compound Name |
[Amino-[[4-[(4-nitrophenoxy)sulfonylmethyl]phenyl]methylsulfanyl]methylidene]azanium;bromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3250026; BDBM50009926
Click to Show/Hide
|
||||
| Activity |
Ki = 1150000 nM
|
[79] | |||
| Compound Name |
3-Amidinophenylpyruvic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3247194; meta-Appa; 3-(3-carbamimidoylphenyl)-2-oxopropanoic acid; SCHEMBL19990975; CTK4J6570; DTXSID00200801; BDBM50010303; 2-Oxo-3-(3-amidinophenyl)propanoic acid; Benzenepropanoic acid,3-(aminoiminomethyl)-a-oxo-; Benzenepropanoic acid, 3-(aminoiminomethyl)-alpha-oxo-
Click to Show/Hide
|
||||
| Activity |
Ki = 1584893.19 nM
|
[27] | |||
| Compound Name |
3-(Hydroxymethyl)benzene-1-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3247181; SCHEMBL8542393; DTXSID60655656; 3-(HYDROXYMETHYL)BENZAMIDINE; BDBM50010244; ZINC36949597; AKOS009346014; SC-38638
Click to Show/Hide
|
||||
| Activity |
Ki = 2511886.43 nM
|
[27] | |||
| Compound Name |
1-Phenylguanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenylguanidine; N-Phenylguanidine; 2-phenylguanidine; GUANIDINE, PHENYL-; alpha-Phenylguanidine; N-Phenyl-guanidine; 1N-amino(immino)methylaniline; CHEMBL14047; EINECS 217-898-7; phenyl guanidine; Monophenylguanidin; N-phenyl guanidine; N-Phenylguanidine #; Guanidine, N-phenyl-; Phenylguanidine mononitrate; SCHEMBL256023; BDBM93095; DTXSID70173836; ALBB-019781; ZINC4276940; BDBM50053620; MFCD00092876; AKOS000266439; MCULE-1696687582; guanidine, N-phenyl-, carbonate(1:1); AM803464; AS-39432; SC-43561; L-4044; J-007368; Q27464460; F2158-0402
Click to Show/Hide
|
||||
| Activity |
Ki = 2610000 nM
|
[80] | |||
| Compound Name |
2-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-cyclohexyl]-propionylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76087; BDBM50081423; N-[3-[(1R,3R)-3-[[N-(Benzyloxycarbonyl)phenylalanyl]amino]-2-oxocyclohexyl]propionyl]phenylalanine
Click to Show/Hide
|
||||
| Activity |
Ki = 3000000 nM
|
[47] | |||
| Compound Name |
3,4-Dimethyl-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,4-DIMETHYLBENZIMIDAMIDE; 3,4-dimethylbenzenecarboximidamide; 3,4-DIMETHYLBENZAMIDINE; CHEMBL3247190; Benzenecarboximidamide, 3,4-dimethyl-; SCHEMBL8404520; CTK4F7119; DTXSID20411058; ZINC1437801; 5252AH; BDBM50010254; Benzenecarboximidamide,3,4-dimethyl-; AKOS002392067; AB21798; NE63197; AK153697; SC-40487; DB-067536; FT-0726516; 3,4-DIMETHYLBENZENE-1-CARBOXIMIDAMIDE; 130D472; A818194
Click to Show/Hide
|
||||
| Activity |
Ki = 3162277.66 nM
|
[27] | |||
| Compound Name |
4-Nitrobenzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Nitro-benzamidine; 4-nitrobenzenecarboximidamide; p-Nitrobenzamidine; Benzenecarboximidamide, 4-nitro-; EINECS 246-952-2; 4-nitrobenzimidamide; SCHEMBL628983; Benzenecarboximidamide,4-nitro-; CHEMBL3350787; BDBM93099; CTK4F5697; DTXSID20180075; ZINC2565176; MFCD01027042; STK396205; AKOS005431301; MB01641; MCULE-6868165476; SC-39188; DB-067394; BB 0240258; FT-0701588; 12N753; N-1005
Click to Show/Hide
|
||||
| Activity |
Ki = 3981071.71 nM
|
[27] | |||
| Compound Name |
3-Bromo-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Bromobenzimidamide; 3-bromobenzenecarboximidamide; 3-bromobenzamidine; 3-bromobenzene-1-carboximidamide; CHEMBL3247191; Benzenecarboximidamide, 3-bromo-; SCHEMBL423581; Benzenecarboximidamide,3-bromo-; CTK4F7182; DTXSID90404972; ZINC1437887; 2211AJ; BDBM50010255; MFCD05662834; AKOS009302769; MCULE-9122583730; NE62735; SB36260; AS-61010; BC005185; SC-40679; FT-0769077
Click to Show/Hide
|
||||
| Activity |
Ki = 7943282.35 nM
|
[27] | |||
| Compound Name |
Chembl317425
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370334; BDBM50079382
Click to Show/Hide
|
||||
| Activity |
Ki = 9000000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 8 | 4-Heterocyclohexanone-based inhibitors of the serine protease plasmin. J Med Chem. 1999 Jul 29;42(15):2969-76. | ||||
| REF 9 | Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. | ||||
| REF 10 | Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3063-8. | ||||
| REF 11 | Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin. Bioorg Med Chem. 2014 Apr 1;22(7):2339-52. | ||||
| REF 12 | Design of benzamidine-type inhibitors of factor Xa. J Med Chem. 1998 Oct 22;41(22):4240-50. | ||||
| REF 13 | Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2297-302. | ||||
| REF 14 | Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. | ||||
| REF 15 | Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. J Med Chem. 1997 Sep 12;40(19):3091-9. | ||||
| REF 16 | 4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2023-6. | ||||
| REF 17 | Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine. Bioorg Med Chem. 2015 Jul 1;23(13):3696-704. | ||||
| REF 18 | Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem. 2007 Dec 27;50(26):6638-46. | ||||
| REF 19 | 4-amidinobenzylamine-based inhibitors of urokinase. Bioorg Med Chem Lett. 2002 Feb 25;12(4):645-8. | ||||
| REF 20 | Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active factor Xa inhibitors. Bioorg Med Chem. 2008 Mar 15;16(6):3125-40. | ||||
| REF 21 | Discovery of imidazo[1,5-c]imidazol-3-ones: weakly basic, orally active factor Xa inhibitors. J Med Chem. 2008 Jun 26;51(12):3422-36. | ||||
| REF 22 | Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2361-6. | ||||
| REF 23 | Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. | ||||
| REF 24 | Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one. Bioorg Med Chem. 2009 Dec 1;17(23):7993-8002. | ||||
| REF 25 | Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA). Bioorg Med Chem. 2012 Feb 15;20(4):1557-68. | ||||
| REF 26 | Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1629-33. | ||||
| REF 27 | Inhibition of four human serine proteases by substituted benzamidines. J Med Chem. 1978 Dec;21(12):1202-7. | ||||
| REF 28 | Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):67-73. | ||||
| REF 29 | Active site-directed plasmin inhibitors: Extension on the P2 residue. Bioorg Med Chem. 2016 Feb 15;24(4):545-53. | ||||
| REF 30 | Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1960-5. | ||||
| REF 31 | Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2907-11. | ||||
| REF 32 | Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. J Med Chem. 2017 Jan 26;60(2):641-657. | ||||
| REF 33 | Design and synthesis of conformationally constrained arginal thrombin inhibitors. Bioorg Med Chem Lett. 1997 Sep 9;7(17):2205-10. | ||||
| REF 34 | Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2947-50. | ||||
| REF 35 | Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens. J Nat Prod. 2007 Oct;70(10):1611-5. | ||||
| REF 36 | Identification of novel plasmin inhibitors possessing nitrile moiety as warhead. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6305-9. | ||||
| REF 37 | Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. J Med Chem. 2005 May 19;48(10):3586-604. | ||||
| REF 38 | Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors. Bioorg Med Chem Lett. 2005 Jan 3;15(1):185-9. | ||||
| REF 39 | Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2357-60. | ||||
| REF 40 | The discovery of orally available thrombin inhibitors: optimisation of the P1 pharmacophore. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1103-8. | ||||
| REF 41 | Highly selective tripeptide thrombin inhibitors. J Med Chem. 1993 Feb 5;36(3):314-9. | ||||
| REF 42 | Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75. | ||||
| REF 43 | Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase. J Med Chem. 2012 Sep 13;55(17):7900-8. | ||||
| REF 44 | Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. J Med Chem. 2013 Apr 25;56(8):3273-80. | ||||
| REF 45 | Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa. Bioorg Med Chem. 2009 Feb 1;17(3):1193-206. | ||||
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