TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T89034 Plasminogen D07UWV Argatroban Approved 92722 C23H36N6O5S 508.6 C[C@@H]1CCN([C@H](C1)C(=O)O)C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C Ki = 257000 nM Non binder T89034 Plasminogen D08YIN Dalfampridine Approved 1727 C5H6N2 94.11 C1=CN=CC=C1N Ki > 2000000 nM Non binder T89034 Plasminogen D0I0RJ Amiloride Approved 16231 C6H8ClN7O 229.63 C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N IC50 > 250000 nM Non binder T89034 Plasminogen B03IEV 1,10-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,10-decanedione Investigative 44315826 C36H54N12O4 718.9 C1CN(CCN1C(=O)CCCCCCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B04MPX [5-[4-[Methyl(2-piperidin-4-ylethyl)carbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate Investigative 44315805 C36H58N10O6 726.9 CN(CCC1CCNCC1)C(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B0B7ZQ N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655489 C24H27N9O5S 553.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)S(=O)(=O)N IC50 = 260000 nM Non binder T89034 Plasminogen B0B8NX (S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide Investigative 10669349 C20H27Cl2N3O2 412.3 C1CCC(CC1)[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3=C(C=CC(=C3)Cl)Cl)N Ki = 691000 nM Non binder T89034 Plasminogen B0BRT2 (2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(naphthalen-2-ylsulfonylamino)pent-4-ynamide Investigative 44264598 C28H31N3O3S 489.6 CNC1=CC=C(C=C1)C#CC[C@@H](C(=O)N(C)C2CCCC2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3 Ki > 200000 nM Non binder T89034 Plasminogen B0E1OY 1beta,5beta-Bis[4-(4-guanidinophenylacetyl)piperazinocarbonyloxy]cyclooctane Investigative 18397357 C36H50N10O6 718.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B0IK7T 2-Chloro-benzenesulfonic acid 3-(3-guanidino-propoxy)-5-methyl-phenyl ester Investigative 44287937 C17H20ClN3O4S 397.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCN=C(N)N Ki > 200000 nM Non binder T89034 Plasminogen B0IM5G Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[6-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]pyridin-2-yl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate Investigative 137649275 C37H17NNa8O38S8 1524 C1=CC(=NC(=C1)COC2=CC(=CC3=C2C(=O)C(=C(O3)C4=CC(=C(C=C4)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COC5=CC(=CC6=C5C(=O)C(=C(O6)C7=CC(=C(C=C7)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] IC50 = 231000 nM Non binder T89034 Plasminogen B0JM6L 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(5-aminopentylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 18397370 C33H54N10O6 686.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCCCN Ki > 1000000 nM Non binder T89034 Plasminogen B0M8CX 1beta,5beta-Bis[4-[4alpha-(aminomethyl)cyclohexane-1beta-ylmethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44315644 C36H64N8O6 704.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3CCC(CC3)CN)OC(=O)N4CCN(CC4)C(=O)NCC5CCC(CC5)CN Ki > 1000000 nM Non binder T89034 Plasminogen B0NBW2 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 44316051 C35H50N10O6 706.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N Ki > 1000000 nM Non binder T89034 Plasminogen B0RW3P Pyridin-4-yl-(2-m-tolyloxy-ethyl)-amine Investigative 44459497 C14H16N2O 228.29 CC1=CC(=CC=C1)OCCNC2=CC=NC=C2 Ki > 500000 nM Non binder T89034 Plasminogen B0TDN5 2-[[6-Amino-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid Investigative 136264091 C7H10N6O3 226.19 C1=C(N=C(C(=N1)/C(=N/O)/N)N)NCC(=O)O IC50 > 250000 nM Non binder T89034 Plasminogen B0UT5V Methyl 3-(2-methyl-1-oxopropoxy)(1)benzothieno(3,2-b)furan-2-carboxylate Investigative 3660962 C16H14O5S 318.3 CC(C)C(=O)OC1=C(OC2=C1SC3=CC=CC=C32)C(=O)OC IC50 = 240000 nM Non binder T89034 Plasminogen B1AZX5 1,4-Bis[1,4-dioxo-4-[methyl[4-(aminomethyl)benzyl]amino]butylaminomethyl]benzene Investigative 44315609 C34H44N6O4 600.8 CN(CC1=CC=C(C=C1)CN)C(=O)CCC(=O)NCC2=CC=C(C=C2)CNC(=O)CCC(=O)N(C)CC3=CC=C(C=C3)CN Ki > 1000000 nM Non binder T89034 Plasminogen B1CR2E 1beta,5beta-Bis[4-[3-(4-guanidinophenyl)propionyl]piperazinocarbonyloxy]cyclooctane Investigative 18397347 C38H54N10O6 746.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B1CUF3 (1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester Investigative 10293977 C18H27N5O5 393.4 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N Ki = 210000 nM Non binder T89034 Plasminogen B1DO6Q N-[(1S)-5-Amino-1-cyanopentyl]-3-[[2-(4-fluorophenyl)acetyl]amino]-4-(pyridin-4-ylmethoxy)benzamide Investigative 57400705 C27H28FN5O3 489.5 C1=CC(=CC=C1CC(=O)NC2=C(C=CC(=C2)C(=O)N[C@@H](CCCCN)C#N)OCC3=CC=NC=C3)F IC50 = 590000 nM Non binder T89034 Plasminogen B1FYN7 1,4-Bis[1,5-dioxo-5-[4-(aminomethyl)benzylamino]pentylaminomethyl]benzene Investigative 44315849 C34H44N6O4 600.8 C1=CC(=CC=C1CN)CNC(=O)CCCC(=O)NCC2=CC=C(C=C2)CNC(=O)CCCC(=O)NCC3=CC=C(C=C3)CN Ki > 1000000 nM Non binder T89034 Plasminogen B1GUP7 Mupain-1 Investigative 101862198 C51H73N13O16S2 1188.3 C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N1)N)C(=O)O)CC(=O)O)CC(C)C)CC3=CC=C(C=C3)O)CCCN=C(N)N)CO)CC4=CC=C(C=C4)O Ki > 1000000 nM Non binder T89034 Plasminogen B1MDZ2 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 44315643 C34H54N10O6 698.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen B1P5DO 3-Bromo-benzamidine Investigative 4620241 C7H7BrN2 199.05 C1=CC(=CC(=C1)Br)C(=N)N Ki = 7943282.35 nM Non binder T89034 Plasminogen B1SK6R [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-methylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carboxylate Investigative 44315788 C36H58N10O6 726.9 CN1CCC(CC1)CCNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B1X2VI (2S)-N-Cyclopentyl-2-[(6-methoxynaphthalen-2-yl)sulfonylamino]-N-methyl-5-[4-(methylamino)phenyl]pent-4-ynamide Investigative 44264660 C29H33N3O4S 519.7 CNC1=CC=C(C=C1)C#CC[C@@H](C(=O)N(C)C2CCCC2)NS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)OC Ki > 200000 nM Non binder T89034 Plasminogen B1XDJ2 D-Ser-Gly-(4-Amidinobenzyl)NH2 Investigative 9922131 C13H19N5O3 293.32 C1=CC(=CC=C1CNC(=O)CNC(=O)[C@@H](CO)N)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B21UTS (2S)-N-[(4-Aminocyclohexyl)methyl]-1-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)acetyl]pyrrolidine-2-carboxamide;hydrochloride Investigative 45264998 C29H36ClN3O2 494.1 C1C[C@H](N(C1)C(=O)CC2C3=CC=CC=C3C=CC4=CC=CC=C24)C(=O)NCC5CCC(CC5)N.Cl Ki = 414000 nM Non binder T89034 Plasminogen B24EPB N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[4-(2-oxopropoxy)phenyl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655495 C27H30N8O5 546.6 CC(=O)COC1=CC=C(C=C1)N2CC(=O)N(C2=O)CC3=CC4=CN=C(N=C4N3C)C(=O)N[C@@H](CCCCN)C#N IC50 = 250000 nM Non binder T89034 Plasminogen B25GKP 1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane Investigative 10439687 C36H56N8O6 696.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CCCC5CCNCC5 Ki = 310000 nM Non binder T89034 Plasminogen B27WSD (2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-[(4-propylphenyl)sulfonylamino]pent-4-ynamide Investigative 10390481 C27H35N3O3S 481.7 CCCC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC#CC2=CC=C(C=C2)NC)C(=O)N(C)C3CCCC3 Ki > 200000 nM Non binder T89034 Plasminogen B2CL5M 2-(Naphthalene-2-sulfonylamino)-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide Investigative 44459488 C26H31N5O4S 509.6 C1CCN(CC1)C(=O)[C@@H](CCNC2=CC=NC=C2)NC(=O)CNS(=O)(=O)C3=CC4=CC=CC=C4C=C3 Ki > 500000 nM Non binder T89034 Plasminogen B2FL3D 2-Chlorobenzenesulfonic acid 3-methyl-5-(1-amidinopiperidine-4-ylmethoxy)phenyl ester Investigative 9910982 C20H24ClN3O4S 437.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCC3CCN(CC3)C(=N)N Ki > 200000 nM Non binder T89034 Plasminogen B2JKZ7 N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-5-oxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655504 C24H27FN8O2 478.5 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CN(CC3=O)C4=CC=C(C=C4)F IC50 = 510000 nM Non binder T89034 Plasminogen B2LT3J N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655491 C25H25N9O3 499.5 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)C#N IC50 = 210000 nM Non binder T89034 Plasminogen B2NL6X N-[(1S)-5-Amino-1-cyanopentyl]-4-(pyridin-4-ylmethoxy)benzamide Investigative 57402478 C19H22N4O2 338.4 C1=CC(=CC=C1C(=O)N[C@@H](CCCCN)C#N)OCC2=CC=NC=C2 IC50 = 240000 nM Non binder T89034 Plasminogen B37FNY (2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1,2,3,4-tetrahydroquinoline-2-carbonyl)pyrrolidine-2-carboxamide Investigative 10409551 C21H30N6O3 414.5 C1C[C@H](N(C1)C(=O)C2CCC3=CC=CC=C3N2)C(=O)N[C@@H](CCCN=C(N)N)C=O IC50 = 660000 nM Non binder T89034 Plasminogen B39FGY 3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide Investigative 44304139 C15H15BrN4O2 363.21 CC1=CC(=C(C(=C1)Br)O)C(=O)NC2=CC=C(C=C2)N=C(N)N Ki = 205000 nM Non binder T89034 Plasminogen B3CY5U [5-[4-[2-[4-(2-Aminoethyl)phenyl]ethylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-[4-(2-aminoethyl)phenyl]ethylcarbamoyl]piperazine-1-carboxylate Investigative 44315914 C40H60N8O6 749 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3=CC=C(C=C3)CCN)OC(=O)N4CCN(CC4)C(=O)NCCC5=CC=C(C=C5)CCN Ki = 570000 nM Non binder T89034 Plasminogen B3DSG9 [Amino-[[4-[(4-nitrophenoxy)sulfonylmethyl]phenyl]methylsulfanyl]methylidene]azanium;bromide Investigative 90655701; 118705719 C15H16BrN3O5S2 462.3 C1=CC(=CC=C1CSC(=[NH2+])N)CS(=O)(=O)OC2=CC=C(C=C2)[N+](=O)[O-].[Br-] Ki = 1150000 nM Non binder T89034 Plasminogen B3M5YL 3-(6-Chloronaphthalen-2-yl)sulfonyl-N-methyl-N-[1-(2-methylpyridin-4-yl)piperidin-4-yl]propanamide Investigative 10117027 C25H28ClN3O3S 486 CC1=NC=CC(=C1)N2CCC(CC2)N(C)C(=O)CCS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)Cl Ki > 200000 nM Non binder T89034 Plasminogen B3O1MD 3-Carbamimidoylbenzoic Acid Investigative 3676069 C8H8N2O2 164.16 C1=CC(=CC(=C1)C(=O)O)C(=N)N Ki = 398107.17 nM Non binder T89034 Plasminogen B3UPV7 3-Phenylbenzenecarboximidamide Investigative 3564407 C13H12N2 196.25 C1=CC=C(C=C1)C2=CC(=CC=C2)C(=N)N Ki = 316227.77 nM Non binder T89034 Plasminogen B3WGY4 2-((R)-3-{(R)-3-[(S)-2-((S)-Benzyloxycarbonylamino)-3-phenyl-propionylamino]-2-oxo-cyclohexyl}-propionylamino)-3-(1H-indol-3-yl)-propionic acid Investigative 11802399 C37H40N4O7 652.7 C1C[C@@H](C(=O)[C@@H](C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)CCC(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)O Ki = 420000 nM Non binder T89034 Plasminogen B41TDK 1,6-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,6-hexanedione Investigative 44315832 C32H46N12O4 662.8 C1CN(CCN1C(=O)CCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N Ki = 316000 nM Non binder T89034 Plasminogen B41YXL N-(2-Phenoxyethyl)pyridin-4-amine Investigative 44459487 C13H14N2O 214.26 C1=CC=C(C=C1)OCCNC2=CC=NC=C2 Ki > 500000 nM Non binder T89034 Plasminogen B43UJG 4-Amino-4-{[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-butyric acid Investigative 73350148 C15H21N5O4 335.36 C1=CC(=CC=C1CNC(=O)CNC(=O)[C@H](CCC(=O)O)N)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B46YQJ N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-1-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide Investigative 57400764 C31H31N5O3 521.6 C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4 IC50 = 570000 nM Non binder T89034 Plasminogen B4CJ5A 1beta-[[4-(4-Amidinophenylacetyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44289295 C35H54N8O6 682.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B4CQ1W 2-[3-(Phenylethynyl)-5-chloro-2-pyridinyl]guanidine Investigative 44298525 C14H11ClN4 270.72 C1=CC=C(C=C1)C#CC2=C(N=CC(=C2)Cl)N=C(N)N Ki = 218000 nM Non binder T89034 Plasminogen B4EZ5H N-(5-Bromo-isoquinolin-1-yl)-guanidine Investigative 44339233 C10H9BrN4 265.11 C1=CC2=C(C=CN=C2N=C(N)N)C(=C1)Br Ki = 237800 nM Non binder T89034 Plasminogen B4H7LS (2S)-N-[(2S)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(1R)-1,2,3,4-tetrahydroisoquinoline-1-carbonyl]pyrrolidine-2-carboxamide Investigative 9801905 C21H30N6O3 414.5 C1C[C@H](N(C1)C(=O)[C@H]2C3=CC=CC=C3CCN2)C(=O)N[C@@H](CCCN=C(N)N)C=O IC50 = 430000 nM Non binder T89034 Plasminogen B4M8CU (4-{2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-3-phenyl-propionylamino}-phenyl)-acetic acid Investigative 10322647 C25H31N3O4 437.5 C1CC(CCC1CN)C(=O)NC(CC2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC(=O)O IC50 = 620000 nM Non binder T89034 Plasminogen B4QA6S (Alphae)-2-(Diaminomethyleneamino)-5-chloropyridine-3-acrylic acid Investigative 44298377 C9H9ClN4O2 240.64 C1=C(C=NC(=C1/C=C/C(=O)O)N=C(N)N)Cl Ki = 278500 nM Non binder T89034 Plasminogen B4R2BH 2-[4-[(3,3-Dimethyl-2,4-dihydro-1H-quinolin-8-yl)sulfonylamino]-5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-oxopentyl]guanidine Investigative 11756005 C24H40N6O4S 508.7 CC1(CC2=C(C(=CC=C2)S(=O)(=O)NC(CCCN=C(N)N)C(=O)N3CCC(CC3)CCO)NC1)C Ki = 210000 nM Non binder T89034 Plasminogen B4U2LW 3-[Bis(6-aminohexyl)amino]tetrahydro-4H-thiopyran-4-one Investigative 10664145 C17H35N3OS 329.5 C1CSCC(C1=O)N(CCCCCCN)CCCCCCN Ki = 400000 nM Non binder T89034 Plasminogen B4VAC3 1,4-Bis[1,4-dioxo-4-(4-guanidinobenzylamino)butylaminomethyl]benzene Investigative 44315846 C32H40N10O4 628.7 C1=CC(=CC=C1CNC(=O)CCC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CCC(=O)NCC3=CC=C(C=C3)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B4W3NK N-[(6-Amino-2-methylpyridin-3-yl)methyl]-1-[[4-(pyrazol-1-ylmethyl)phenyl]methyl]pyrazole-4-carboxamide Investigative 134130781 C22H23N7O 401.5 CC1=C(C=CC(=N1)N)CNC(=O)C2=CN(N=C2)CC3=CC=C(C=C3)CN4C=CC=N4 IC50 > 1000000 nM Non binder T89034 Plasminogen B53DIN 3-[4-(Guanidinomethyl)phenyl]-6-methylenetetrahydro-2H-pyran-2-one Investigative 10264543 C14H17N3O2 259.3 C=C1CCC(C(=O)O1)C2=CC=C(C=C2)CN=C(N)N Ki = 466000 nM Non binder T89034 Plasminogen B53VWR Tert-butyl 3-[3-[5-[[(1S)-5-amino-1-cyanopentyl]carbamoyl]-2-(pyridin-4-ylmethoxy)anilino]-3-oxopropyl]indole-1-carboxylate Investigative 57390236 C35H40N6O5 624.7 CC(C)(C)OC(=O)N1C=C(C2=CC=CC=C21)CCC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4 IC50 = 220000 nM Non binder T89034 Plasminogen B54PRQ Benzyl 2-[[6-amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetate Investigative 136266885 C14H15ClN6O3 350.76 C1=CC=C(C=C1)COC(=O)CNC2=NC(=C(N=C2Cl)/C(=N/O)/N)N IC50 > 250000 nM Non binder T89034 Plasminogen B56DJG 1,3-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]adamantane Investigative 44315449 C40H56N12O6 800.9 C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)OCC34CC5CC(C3)CC(C5)(C4)COC(=O)N6CCN(CC6)C(=O)NCC7=CC=C(C=C7)N=C(N)N Ki = 576000 nM Non binder T89034 Plasminogen B5A2UB N-[3-[2-(Pyridin-4-ylamino)ethoxy]phenyl]naphthalene-2-sulfonamide Investigative 15227625 C23H21N3O3S 419.5 C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NC3=CC(=CC=C3)OCCNC4=CC=NC=C4 Ki > 500000 nM Non binder T89034 Plasminogen B5F9LD Benzyl 2-[(6-amino-5-carbamoyl-3-chloropyrazin-2-yl)amino]acetate Investigative 70689516 C14H14ClN5O3 335.74 C1=CC=C(C=C1)COC(=O)CNC2=NC(=C(N=C2Cl)C(=O)N)N IC50 > 250000 nM Non binder T89034 Plasminogen B5NPB7 1,8-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,8-octanedione Investigative 9810198 C34H50N12O4 690.8 C1CN(CCN1C(=O)CCCCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B5O3JK 1-Phenylguanidine Investigative 16157 C7H9N3 135.17 C1=CC=C(C=C1)N=C(N)N Ki = 2610000 nM Non binder T89034 Plasminogen B5S3JN (3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-11-(carboxymethyl)-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid Investigative 127037469 C54H77N13O16S2 1228.4 C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N1)N)C(=O)O)CC(=O)O)CC(C)C)CC3=CC=C(C=C3)O)CC4CCN(CC4)C(=N)N)CO)CC5=CC=C(C=C5)O Ki > 1000000 nM Non binder T89034 Plasminogen B5W6NO (2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid Investigative 44347573 C29H36F3N3O4 547.6 C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O Ki = 744000 nM Non binder T89034 Plasminogen B5YW4G N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-4-(4-phenoxyphenyl)piperazin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655506 C31H32N8O4 580.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CC(=O)N(CC3=O)C4=CC=C(C=C4)OC5=CC=CC=C5 IC50 = 960000 nM Non binder T89034 Plasminogen B60XYD 2-[(E)-1-[3-(Benzenesulfonamido)-5-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]ethylideneamino]guanidine Investigative 53322612 C18H23N9O2S 429.5 C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NS(=O)(=O)C2=CC=CC=C2)/C(=N/N=C(N)N)/C Ki = 400000 nM Non binder T89034 Plasminogen B65DTR [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(6-aminopyridin-3-yl)propanoyl]piperazine-1-carboxylate Investigative 44315852 C35H50N10O6 706.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CN=C(C=C5)N Ki > 1000000 nM Non binder T89034 Plasminogen B6BMZ9 3-[2-Amino-3-(4-methanesulfonyl-piperazin-1-yl)-3-oxo-propyl]-benzamidine Investigative 4713416 C15H23N5O3S 353.4 CS(=O)(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)N)N Ki > 1000000 nM Non binder T89034 Plasminogen B6CMA3 2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-3-ylmethoxy)-5-methyl-phenyl ester Investigative 44287798 C20H24ClN3O4S 437.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCC3CCCN(C3)C(=N)N Ki > 200000 nM Non binder T89034 Plasminogen B6D1VB 1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylaminomethyl]piperidino]carbonyloxymethyl]benzene Investigative 44289263 C36H58N8O6 698.9 C1CN(CCC1CN)C(=O)NCC2CCN(CC2)C(=O)OCC3=CC=C(C=C3)COC(=O)N4CCC(CC4)CNC(=O)N5CCC(CC5)CN Ki > 1000000 nM Non binder T89034 Plasminogen B6HSN9 2-{(R)-3-[(R)-3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-cyclohexyl]-propionylamino}-3-phenyl-propionic acid Investigative 10438758 C35H39N3O7 613.7 C1C[C@@H](C(=O)[C@@H](C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)CCC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O Ki = 3000000 nM Non binder T89034 Plasminogen B6MR9Z 2-Acetylamino-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-propionamide Investigative 10131788 C15H21N5O4 335.36 CC(=O)N[C@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B6MWG7 1beta,5beta-Bis[4-[4-(aminomethyl)benzylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 18397354 C36H52N8O6 692.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)CN)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)CN Ki > 1000000 nM Non binder T89034 Plasminogen B6O3KR 1,4-Bis[1,4-dioxo-4-[4-(aminomethyl)benzylamino]butylaminomethyl]benzene Investigative 44315607 C32H40N6O4 572.7 C1=CC(=CC=C1CN)CNC(=O)CCC(=O)NCC2=CC=C(C=C2)CNC(=O)CCC(=O)NCC3=CC=C(C=C3)CN Ki = 769000 nM Non binder T89034 Plasminogen B6RQ5D Tetrasodium;[4-[4-oxo-5-[3-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxypropoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate Investigative 137642080 C33H20Na4O22S4 988.7 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C=C3OCCCOC4=CC(=CC5=C4C(=O)C=C(O5)C6=CC=C(C=C6)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+] IC50 > 1000000 nM Non binder T89034 Plasminogen B6ST8W (2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid Investigative 44347533 C28H35F3N4O4 548.6 C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=N3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O Ki > 1000000 nM Non binder T89034 Plasminogen B6WB1G 1-Methyl-1h-indole-5-carboximidamide Investigative 18545754 C10H11N3 173.21 CN1C=CC2=C1C=CC(=C2)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B6Z1CQ [5-[4-[[4-(Aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carboxylate Investigative 44315391 C40H68N8O6 757 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC34CCC(CC3)(CC4)CN)OC(=O)N5CCN(CC5)C(=O)NCC67CCC(CC6)(CC7)CN Ki > 1000000 nM Non binder T89034 Plasminogen B70AVX 4-Tert-Butoxycarbonylamino-4-{[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-butyric acid Investigative 44372724 C20H29N5O6 435.5 CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B7B1JV N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-[2-oxo-3-(pyridin-4-ylmethyl)-1,3-benzoxazol-6-yl]imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 122179838 C31H30N10O5 622.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC5=C(C=C4)N(C(=O)O5)CC6=CC=NC=C6 IC50 > 200000 nM Non binder T89034 Plasminogen B7JQS3 N-Methyl-N-[3-[2-(pyridin-4-ylamino)ethoxy]phenyl]benzenesulfonamide Investigative 11811066 C20H21N3O3S 383.5 CN(C1=CC(=CC=C1)OCCNC2=CC=NC=C2)S(=O)(=O)C3=CC=CC=C3 Ki > 500000 nM Non binder T89034 Plasminogen B7O3FM 1beta,5beta-Bis[3-(4-guanidinobenzyl)ureidoacetoxy]cyclooctane Investigative 44315758 C30H42N10O6 638.7 C1CC(CCCC(C1)OC(=O)CNC(=O)NCC2=CC=C(C=C2)N=C(N)N)OC(=O)CNC(=O)NCC3=CC=C(C=C3)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen B7RI4S 2-[(6-Amino-5-carbamimidoylpyrazin-2-yl)amino]acetic acid Investigative 70683232 C7H10N6O2 210.19 C1=C(N=C(C(=N1)C(=N)N)N)NCC(=O)O IC50 > 250000 nM Non binder T89034 Plasminogen B7XBU2 3,4-Dimethyl-benzamidine Investigative 5221300 C9H12N2 148.2 CC1=C(C=C(C=C1)C(=N)N)C Ki = 3162277.66 nM Non binder T89034 Plasminogen B7XE9V 2-[[6-Amino-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid Investigative 70695842 C8H11N7O3 253.22 C1=C(N=C(C(=N1)C(=O)N=C(N)N)N)NCC(=O)O IC50 > 250000 nM Non binder T89034 Plasminogen B83JAT [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-piperidin-4-ylpropylcarbamoyl)piperazine-1-carboxylate Investigative 44315641 C36H58N10O6 726.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen B8G7RC (3Aalpha,6aalpha)-3beta,6beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]hexahydrofuro[3,2-b]furan Investigative 9896889 C34H46N12O8 750.8 C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N Ki = 700000 nM Non binder T89034 Plasminogen B8JTK2 2-(4-Chloro-benzenesulfonylamino)-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide Investigative 44459090 C22H28ClN5O4S 494 C1CCN(CC1)C(=O)[C@@H](CCNC2=CC=NC=C2)NC(=O)CNS(=O)(=O)C3=CC=C(C=C3)Cl Ki > 500000 nM Non binder T89034 Plasminogen B8MF4U 3-Hydroxy-N-{[4-(N-hydroxycarbamimidoyl)-benzylcarbamoyl]-methyl}-2-phenylmethanesulfonylamino-propionamide Investigative 44372840 C20H25N5O6S 463.5 C1=CC=C(C=C1)CS(=O)(=O)N[C@H](CO)C(=O)NCC(=O)NCC2=CC=C(C=C2)/C(=N/O)/N Ki > 1000000 nM Non binder T89034 Plasminogen B8NHO4 3-Nitrobenzamidine hydrochloride Investigative 12456162 C7H8ClN3O2 201.61 C1=CC(=CC(=C1)[N+](=O)[O-])C(=N)N.Cl Ki = 1000000 nM Non binder T89034 Plasminogen B8O2DV 1,4-Bis[[2-oxo-2-(1-amidino-4-piperidinylmethylamino)ethyl]carbamoyloxymethyl]benzene Investigative 44289153 C28H44N10O6 616.7 C1CN(CCC1CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3CCN(CC3)C(=N)N)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen B8VYZ0 Benzyl 2-[[6-amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetate Investigative 57404503 C15H16ClN7O3 377.78 C1=CC=C(C=C1)COC(=O)CNC2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N IC50 > 250000 nM Non binder T89034 Plasminogen B8W9GQ N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[3-[3-(2-methylpropyl)-2-oxo-1,3-benzoxazol-6-yl]-2,5-dioxoimidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 122179837 C29H33N9O5 587.6 CC(C)CN1C2=C(C=C(C=C2)N3CC(=O)N(C3=O)CC4=CC5=CN=C(N=C5N4C)C(=O)N[C@@H](CCCCN)C#N)OC1=O IC50 > 200000 nM Non binder T89034 Plasminogen B9AN7K N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-4-guanidinobutanamide Investigative 53321291 C17H28N12O 416.5 C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NC(=O)CCCN=C(N)N)/C(=N/N=C(N)N)/C Ki = 1000000 nM Non binder T89034 Plasminogen B9HXG4 (2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(2S)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide Investigative 44358867 C22H34N6O3 430.5 C[C@](CCCN=C(N)N)(C=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=CC=C2)NC IC50 = 850000 nM Non binder T89034 Plasminogen B9I3UR (2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid Investigative 44347477 C28H35F3N4O4 548.6 C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CC=NC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O Ki = 744000 nM Non binder T89034 Plasminogen B9IJC0 2-Methyl-benzamidine Investigative 576480 C8H10N2 134.18 CC1=CC=CC=C1C(=N)N Ki = 316227.77 nM Non binder T89034 Plasminogen B9K5NJ 3-Benzoyl-1H-indole-6-carboxamidine Investigative 44331672 C16H13N3O 263.29 C1=CC=C(C=C1)C(=O)C2=CNC3=C2C=CC(=C3)C(=N)N Ki > 200000 nM Non binder T89034 Plasminogen B9MU1R 1beta,5beta-Bis[4-(6-aminohexylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 18397360 C32H60N8O6 652.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCCCCCN)OC(=O)N3CCN(CC3)C(=O)NCCCCCCN Ki > 1000000 nM Non binder T89034 Plasminogen B9OBX0 2-Phenyl-1H-benzimidazole-5-carboxamidine Investigative 11009950 C14H12N4 236.27 C1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N Ki = 350000 nM Non binder T89034 Plasminogen B9WUT5 [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-imidazol-1-ylbutanoyl)piperazine-1-carboxylate Investigative 44315850 C34H50N10O6 694.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCN5C=CN=C5 Ki > 1000000 nM Non binder T89034 Plasminogen B9ZS3P 1beta,5beta-Bis[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 44315845 C34H46N6O6 634.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=CC=C3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=CC=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BA0CY1 N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(3-sulfamoylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655492 C24H27N9O5S 553.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC(=CC=C4)S(=O)(=O)N IC50 = 220000 nM Non binder T89034 Plasminogen BA4F9W [5-[4-[[4-[(E)-N'-Methoxycarbonylcarbamimidoyl]phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate Investigative 44289180 C37H57N9O8 755.9 COC(=O)/N=C(\\C1=CC=C(C=C1)CNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5)/N Ki > 1000000 nM Non binder T89034 Plasminogen BA7SG3 3-Methoxy-benzamidine Investigative 5108695 C8H10N2O 150.18 COC1=CC=CC(=C1)C(=N)N Ki = 316227.77 nM Non binder T89034 Plasminogen BAH0Z8 1beta,5beta-Bis[4-[2-[1-(1-iminoethyl)-4-piperidinyl]ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44315635 C38H66N10O6 759 CC(=N)N1CCC(CC1)CCNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCCC5CCN(CC5)C(=N)C Ki > 1000000 nM Non binder T89034 Plasminogen BARC31 N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[[5-oxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655505 C30H32N8O3 552.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3CN(CC3=O)C4=CC=C(C=C4)OC5=CC=CC=C5 IC50 > 250000 nM Non binder T89034 Plasminogen BBSN72 2-(5-Methylpyridin-2-yl)guanidine Investigative 10219529 C7H10N4 150.18 CC1=CN=C(C=C1)N=C(N)N Ki = 245000 nM Non binder T89034 Plasminogen BC18OI 1beta,5beta-Bis[4-(4-aminobutylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 18397353 C28H52N8O6 596.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCCCN)OC(=O)N3CCN(CC3)C(=O)NCCCCN Ki > 1000000 nM Non binder T89034 Plasminogen BC7L3X [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylate Investigative 44315392 C35H56N10O6 712.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCC(CC5)N Ki > 1000000 nM Non binder T89034 Plasminogen BCAL64 3-Hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide Investigative 44304104 C22H18N4O2 370.4 C1=CC=C2C=C3C=C(C(=CC3=CC2=C1)C(=O)NC4=CC=C(C=C4)N=C(N)N)O Ki = 283000 nM Non binder T89034 Plasminogen BD68OR N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-6-guanidinohexanamide Investigative 53325236 C19H32N12O 444.5 C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NC(=O)CCCCCN=C(N)N)/C(=N/N=C(N)N)/C Ki = 1000000 nM Non binder T89034 Plasminogen BD8A6V N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-quinolin-6-yloxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655500 C33H31N9O4 617.7 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC6=C(C=C5)N=CC=C6 IC50 > 250000 nM Non binder T89034 Plasminogen BDKG59 N-[(1S)-5-Amino-1-cyanopentyl]-3-[(2-naphthalen-2-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide Investigative 57393799 C31H31N5O3 521.6 C1=CC=C2C=C(C=CC2=C1)CC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4 IC50 = 220000 nM Non binder T89034 Plasminogen BDOA26 1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 10055497 C35H55N9O6 697.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5 Ki = 287000 nM Non binder T89034 Plasminogen BE4NJ5 1beta,5beta-Bis[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane Investigative 44315605 C36H62N6O6 674.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCCC3CCNCC3)OC(=O)N4CCN(CC4)C(=O)CCCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen BE6QN7 1beta,5beta-Bis[4-(1-amidino-4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 18397380 C34H60N12O6 732.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCN(CC5)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BE89LK 4-Chloro-N-(2-{3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-ethyl)-benzenesulfonamide Investigative 19388089 C21H22ClN3O3S 431.9 C1=CC(=CC(=C1)OCCNC2=CC=NC=C2)CCNS(=O)(=O)C3=CC=C(C=C3)Cl Ki > 500000 nM Non binder T89034 Plasminogen BEB74W (2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2S)-2-methoxy-2-phenylacetyl]pyrrolidine-2-carboxamide Investigative 44337989 C20H29N5O4 403.5 CO[C@@H](C1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)NC(CCCN=C(N)N)C=O IC50 = 860000 nM Non binder T89034 Plasminogen BEC0I4 2-Chlorobenzenesulfonic acid 3-methyl-5-(4-guanidinobutoxy)phenyl ester Investigative 44288029 C18H22ClN3O4S 411.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCN=C(N)N Ki > 200000 nM Non binder T89034 Plasminogen BEF5R0 1-(4-Carbamimidoyl-2-chloro-benzyl)-1H-indole-5-carboxamidine Investigative 44331643 C17H16ClN5 325.8 C1=CC(=C(C=C1C(=N)N)Cl)CN2C=CC3=C2C=CC(=C3)C(=N)N Ki > 700000 nM Non binder T89034 Plasminogen BEO67L 1beta,5beta-Bis[4-(1-amidino-4-piperidinylacetyl)piperazinocarbonyloxy]cyclooctane Investigative 18397341 C34H58N10O6 702.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CC5CCN(CC5)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BF8ON7 (2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-3-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid Investigative 44347479 C28H35F3N4O4 548.6 C1C[C@H](N(C1)C(=O)CC(C2=CC=CC=C2)C3=CN=CC=C3)C(=O)NCC4CCC(CC4)N.C(=O)(C(F)(F)F)O Ki > 1000000 nM Non binder T89034 Plasminogen BFGD03 1beta,5beta-Bis[4-[3-(1-amidino-4-piperidinyl)propionyl]piperazinocarbonyloxy]cyclooctane Investigative 18397345 C36H62N10O6 730.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CCC5CCN(CC5)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BFM5W3 Vaborbactam Investigative 56649692 C12H16BNO5S 297.14 B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)CC2=CC=CS2)O IC50 > 1000000 nM Non binder T89034 Plasminogen BG1L8J 1beta,5beta-Bis[4-[1-(1-iminoethyl)-4-piperidinylmethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44315636 C36H62N10O6 730.9 CC(=N)N1CCC(CC1)CNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5CCN(CC5)C(=N)C Ki > 1000000 nM Non binder T89034 Plasminogen BG50PZ 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobutylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 22010099 C32H52N10O6 672.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCCN Ki > 1000000 nM Non binder T89034 Plasminogen BG7V4I Benzamidine hydrochloride hydrate Investigative 16219042 C7H11ClN2O 174.63 C1=CC=C(C=C1)C(=N)N.O.Cl Ki = 501187.23 nM Non binder T89034 Plasminogen BGAM94 (2S)-6-Amino-2-[[(2S)-2-[[(2R,3R)-2-amino-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Investigative 57390228 C21H35N5O3 405.5 CC[C@@H](C)[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N)N IC50 = 290000 nM Non binder T89034 Plasminogen BGO57Z 1-{4-[4-Amino(imino)methylphenylcarbamoylmethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane Investigative 44289296 C36H56N8O6 696.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCC(CC4)CC(=O)NC5=CC=C(C=C5)C(=N)N Ki = 293000 nM Non binder T89034 Plasminogen BGX91W N-[3-(1,3-Benzothiazol-2-yl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide Investigative 44287043 C28H36N4O3S2 540.7 CCC1CCN(CC1)C(=O)C(CC2=NC3=CC=CC=C3S2)NS(=O)(=O)C4=CC=CC5=C4NCC(C5)(C)C Ki = 240000 nM Non binder T89034 Plasminogen BI1R2Q Benzyl 2-[(6-amino-5-carbamimidoyl-3-chloropyrazin-2-yl)amino]acetate Investigative 57404502 C14H15ClN6O2 334.76 C1=CC=C(C=C1)COC(=O)CNC2=NC(=C(N=C2Cl)C(=N)N)N IC50 > 250000 nM Non binder T89034 Plasminogen BI34AP [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-pyridin-4-ylethylcarbamoyl)piperazine-1-carboxylate Investigative 44315675 C35H50N10O6 706.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5=CC=NC=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BI40YG 1-{4-[4-Amino(imino)methylphenylcarboxamidomethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane Investigative 44289336 C36H56N8O6 696.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCC(CC4)CNC(=O)C5=CC=C(C=C5)C(=N)N Ki = 279000 nM Non binder T89034 Plasminogen BI75RZ [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate Investigative 44315642 C35H56N10O6 712.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen BID0U2 (2R)-2-Amino-N-[(2S)-1-[6-aminohexyl(cyclohexyl)amino]-1-oxo-3-phenylpropan-2-yl]-3-methylpentanamide Investigative 44332152 C27H46N4O2 458.7 CCC(C)[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(CCCCCCN)C2CCCCC2)N Ki = 520000 nM Non binder T89034 Plasminogen BJ0K3H N-[(1S)-5-Amino-1-cyanopentyl]-5-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-1,3-benzoxazole-2-carboxamide Investigative 122179840 C24H23FN6O4 478.5 C1C(=O)N(C(=O)N1C2=CC=C(C=C2)F)CC3=CC4=C(C=C3)OC(=N4)C(=O)N[C@@H](CCCCN)C#N IC50 > 200000 nM Non binder T89034 Plasminogen BJ1U8N 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride Investigative 186136 C8H11ClFNO2S 239.7 C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl IC50 = 240000 nM Non binder T89034 Plasminogen BJ37QX N-[(1S)-5-Amino-1-cyanopentyl]-3-[3-(1H-indol-3-yl)propanoylamino]-4-(pyridin-4-ylmethoxy)benzamide Investigative 57397312 C30H32N6O3 524.6 C1=CC=C2C(=C1)C(=CN2)CCC(=O)NC3=C(C=CC(=C3)C(=O)N[C@@H](CCCCN)C#N)OCC4=CC=NC=C4 IC50 = 370000 nM Non binder T89034 Plasminogen BJ7RE1 2-[[6-Amino-3-chloro-5-(diaminomethylidenecarbamoyl)pyrazin-2-yl]amino]acetic acid Investigative 11277660 C8H10ClN7O3 287.66 C(C(=O)O)NC1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N IC50 > 250000 nM Non binder T89034 Plasminogen BJB5I0 1,7-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,7-heptanedione Investigative 44315831 C33H48N12O4 676.8 C1CN(CCN1C(=O)CCCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BJM6H2 [1-[(Benzyloxycarbonyl)amino]-4-aminobutyl]phosphonic acid diphenyl ester Investigative 10895700 C24H27N2O5P 454.5 C1=CC=C(C=C1)COC(=O)NC(CCCN)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3 IC50 > 250000 nM Non binder T89034 Plasminogen BK2PW0 N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-carbamoyl-4-phenoxyphenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655502 C31H31N9O5 609.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC(=C(C=C4)OC5=CC=CC=C5)C(=O)N IC50 = 510000 nM Non binder T89034 Plasminogen BK7J6D [(2S,3S)-3-[[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxymethyl]-2-bicyclo[2.2.2]oct-5-enyl]methyl 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate Investigative 44315664 C38H52N12O6 772.9 C1CC2C=CC1[C@@H]([C@H]2COC(=O)N3CCN(CC3)C(=O)NCC4=CC=C(C=C4)N=C(N)N)COC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N Ki = 700000 nM Non binder T89034 Plasminogen BK7N4X 2-Chlorophenyl[3-[2-[methyl(4-pyridyl)amino]ethoxy]-5-methylphenoxy] sulfone Investigative 10094378 C21H21ClN2O4S 432.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCN(C)C3=CC=NC=C3 Ki > 200000 nM Non binder T89034 Plasminogen BKCY57 1H-Indole-6-carboximidamide, 3-(2,2,2-trifluoroacetyl)- Investigative 44331988 C11H8F3N3O 255.2 C1=CC2=C(C=C1C(=N)N)NC=C2C(=O)C(F)(F)F Ki > 1000000 nM Non binder T89034 Plasminogen BKF8A4 (2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-(1H-indole-2-carbonyl)pyrrolidine-2-carboxamide Investigative 44337935 C20H26N6O3 398.5 C1C[C@H](N(C1)C(=O)C2=CC3=CC=CC=C3N2)C(=O)NC(CCCN=C(N)N)C=O IC50 = 420000 nM Non binder T89034 Plasminogen BKQP83 (2R)-2-Amino-N-[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]-5-(diaminomethylideneamino)pentanamide Investigative 53317375 C18H31N13O 445.5 C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NC(=O)[C@@H](CCCN=C(N)N)N)/C(=N/N=C(N)N)/C Ki = 1000000 nM Non binder T89034 Plasminogen BKX0G2 1,9-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,9-nonanedione Investigative 44315848 C35H52N12O4 704.9 C1CN(CCN1C(=O)CCCCCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BKXL29 1,4-Bis[[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene Investigative 9872983 C30H36N6O6 576.6 C1=CC(=CC=C1CN)CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3=CC=C(C=C3)CN Ki > 1000000 nM Non binder T89034 Plasminogen BL3G5E (2S)-N-[(4-Aminocyclohexyl)methyl]-1-[3-(1,3-benzodioxol-5-yl)-3-pyridin-3-ylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid Investigative 44347623 C29H35F3N4O6 592.6 C1C[C@H](N(C1)C(=O)CC(C2=CC3=C(C=C2)OCO3)C4=CN=CC=C4)C(=O)NCC5CCC(CC5)N.C(=O)(C(F)(F)F)O Ki = 572000 nM Non binder T89034 Plasminogen BLHQ82 1,4-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]benzene Investigative 44315677 C36H46N12O6 742.8 C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)OCC3=CC=C(C=C3)COC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BLOX84 Chembl317425 Investigative 73353028 C20H29N3O3S 391.5 CC[C@H](C)[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC2CSCCC2=O)N Ki = 9000000 nM Non binder T89034 Plasminogen BLRQ02 (S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-amino)-acetyl]-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide Investigative 10744643 C26H38Cl2N4O3 525.5 CCN(CC)C(=O)CN[C@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NCC3=C(C=CC(=C3)Cl)Cl Ki = 244000 nM Non binder T89034 Plasminogen BLWG35 1,4-Bis[methyl[1,4-dioxo-4-[4-(aminomethyl)benzylamino]butyl]aminomethyl]benzene Investigative 44315608 C34H44N6O4 600.8 CN(CC1=CC=C(C=C1)CN(C)C(=O)CCC(=O)NCC2=CC=C(C=C2)CN)C(=O)CCC(=O)NCC3=CC=C(C=C3)CN Ki = 214000 nM Non binder T89034 Plasminogen BM9N8C 1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylamino]butyl]carbamoyloxymethyl]benzene Investigative 44289264 C32H54N8O6 646.8 C1CN(CCC1CN)C(=O)NCCCCNC(=O)OCC2=CC=C(C=C2)COC(=O)NCCCCNC(=O)N3CCC(CC3)CN Ki > 1000000 nM Non binder T89034 Plasminogen BMTK54 [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(5-imidazol-1-ylpentanoyl)piperazine-1-carboxylate Investigative 44316065 C35H52N10O6 708.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCCN5C=CN=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BN19PZ 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(3-aminopropylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 22010100 C31H50N10O6 658.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCN Ki > 1000000 nM Non binder T89034 Plasminogen BN3B0I 3-Amidinophenylpyruvic acid Investigative 3016780 C10H10N2O3 206.2 C1=CC(=CC(=C1)C(=N)N)CC(=O)C(=O)O Ki = 1584893.19 nM Non binder T89034 Plasminogen BN3C2F 1beta,5beta-Bis[4-[2-(1-amidino-4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 18397342 C36H64N12O6 761 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCN(CC5)C(=N)N Ki = 632000 nM Non binder T89034 Plasminogen BN7U2Z 4-Chloro-N-{3-[2-(pyridin-4-ylamino)-ethoxy]-phenyl}-benzenesulfonamide Investigative 15227963 C19H18ClN3O3S 403.9 C1=CC(=CC(=C1)OCCNC2=CC=NC=C2)NS(=O)(=O)C3=CC=C(C=C3)Cl Ki > 500000 nM Non binder T89034 Plasminogen BN85OD [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(2-aminopyrimidin-5-yl)propanoyl]piperazine-1-carboxylate Investigative 44315851 C34H49N11O6 707.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CN=C(N=C5)N Ki > 1000000 nM Non binder T89034 Plasminogen BNC1Q7 1,4-Bis[methyl[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene Investigative 44316050 C32H40N6O6 604.7 CN(CC(=O)NCC1=CC=C(C=C1)CN)C(=O)OCC2=CC=C(C=C2)COC(=O)N(C)CC(=O)NCC3=CC=C(C=C3)CN Ki > 230000 nM Non binder T89034 Plasminogen BNS8F1 1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 44315744 C35H49N9O6 691.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=CC=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BOL28Z (S)-N-((1-Carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide Investigative 45486354 C32H55N13O4 685.9 CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC1CCN(CC1)C(=N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC2=CC=CC=C2 Ki > 1000000 nM Non binder T89034 Plasminogen BOL5J8 1,4-Bis[1,3-dioxo-3-[4-(aminomethyl)benzylamino]propylaminomethyl]benzene Investigative 44315637 C30H36N6O4 544.6 C1=CC(=CC=C1CN)CNC(=O)CC(=O)NCC2=CC=C(C=C2)CNC(=O)CC(=O)NCC3=CC=C(C=C3)CN Ki > 1000000 nM Non binder T89034 Plasminogen BP02UV 3-(3-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid Investigative 10718240 C19H22N6O5S 446.5 C1=CC(=CC(=C1)C(=N)N)CC(C(=O)O)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BPH6K7 [5-[4-(6-Imidazol-1-ylhexanoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(6-imidazol-1-ylhexanoyl)piperazine-1-carboxylate Investigative 44315604 C36H56N8O6 696.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCCCCN3C=CN=C3)OC(=O)N4CCN(CC4)C(=O)CCCCCN5C=CN=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BPJL62 1beta,5beta-Bis[4-[4-(methylaminomethyl)benzylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44315915 C38H56N8O6 720.9 CNCC1=CC=C(C=C1)CNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)CNC Ki > 1000000 nM Non binder T89034 Plasminogen BPS72M N-[(1S)-5-Amino-1-cyanopentyl]-2-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-1-methylbenzimidazole-5-carboxamide Investigative 122179844 C31H31N7O4 565.6 CN1C2=C(C=C(C=C2)C(=O)N[C@@H](CCCCN)C#N)N=C1CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OC5=CC=CC=C5 IC50 > 200000 nM Non binder T89034 Plasminogen BQ57NV (13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one Investigative 134131084 C29H33N7O3 527.6 CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCCC/C=C\\CCOC2=CC(=N1)N)N=C3 IC50 > 200000 nM Non binder T89034 Plasminogen BQR8W9 Tetrasodium;[4-[4-oxo-5-[4-[4-oxo-7-sulfonatooxy-2-(4-sulfonatooxyphenyl)chromen-5-yl]oxybutoxy]-7-sulfonatooxychromen-2-yl]phenyl] sulfate Investigative 137637957 C34H22Na4O22S4 1002.8 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C=C3OCCCCOC4=CC(=CC5=C4C(=O)C=C(O5)C6=CC=C(C=C6)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+] IC50 = 282000 nM Non binder T89034 Plasminogen BQT31C 2-[[6-Amino-3-chloro-5-[(Z)-N'-hydroxycarbamimidoyl]pyrazin-2-yl]amino]acetic acid Investigative 136268735 C7H9ClN6O3 260.64 C(C(=O)O)NC1=NC(=C(N=C1Cl)/C(=N/O)/N)N IC50 > 250000 nM Non binder T89034 Plasminogen BQU29F [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-piperidin-4-ylbutanoyl)piperazine-1-carboxylate Investigative 44315674 C36H57N9O6 711.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen BR1T4G 1,4-Bis[1,5-dioxo-5-(4-guanidinobenzylamino)pentylaminomethyl]benzene Investigative 44315743 C34H44N10O4 656.8 C1=CC(=CC=C1CNC(=O)CCCC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CCCC(=O)NCC3=CC=C(C=C3)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BRSM43 3-(Hydroxymethyl)benzene-1-carboximidamide Investigative 43165100 C8H10N2O 150.18 C1=CC(=CC(=C1)C(=N)N)CO Ki = 2511886.43 nM Non binder T89034 Plasminogen BRT12F N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-propylphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655488 C27H32N8O3 516.6 CCCC1=CC=C(C=C1)N2CC(=O)N(C2=O)CC3=CC4=CN=C(N=C4N3C)C(=O)N[C@@H](CCCCN)C#N IC50 = 330000 nM Non binder T89034 Plasminogen BRV7C5 [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(6-imidazol-1-ylhexanoyl)piperazine-1-carboxylate Investigative 44316026 C36H54N10O6 722.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCCCN5C=CN=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BS01HF 1beta,5beta-Bis[4-(5-aminopentylcarbamoyl)piperazinocarbonyloxy]cyclooctane Investigative 18397359 C30H56N8O6 624.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCCCCN)OC(=O)N3CCN(CC3)C(=O)NCCCCCN Ki > 1000000 nM Non binder T89034 Plasminogen BS5JV1 1,4-Bis[[2-oxo-2-[2-(1-amidino-4-piperidinyl)ethylamino]ethyl]carbamoyloxymethyl]benzene Investigative 44289132 C30H48N10O6 644.8 C1CN(CCC1CCNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCCC3CCN(CC3)C(=N)N)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BS7C3I 1beta-[[4-(4-Amidinobenzoylaminomethyl)piperidino]carbonyloxy]-5beta-[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane Investigative 44289354 C37H57N7O6 695.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCCC3CCNCC3)OC(=O)N4CCC(CC4)CNC(=O)C5=CC=C(C=C5)C(=N)N Ki = 320000 nM Non binder T89034 Plasminogen BSE39M CGH-1484A free base Investigative 9962561 C41H56FN7O6S2 826.1 CC1(CC2=C(C(=CC(=C2)CCC(=O)N3CCN(CC3)CC(=O)N4CCOCC4)S(=O)(=O)N[C@@H](CC5=NC6=CC=CC=C6S5)C(=O)N7CCC(CC7)CCF)NC1)C Ki = 212000 nM Non binder T89034 Plasminogen BSHJ62 1-{4-[4-Amino(imino)methylphenylsulfonamidomethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane Investigative 44289297 C35H56N8O7S 732.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCC(CC4)CNS(=O)(=O)C5=CC=C(C=C5)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BSIA45 1alpha,4beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]cyclohexane Investigative 18397340 C36H52N12O6 748.9 C1CC(CCC1COC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)COC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BSTG05 1,4-Bis[1,3-dioxo-3-(4-guanidinobenzylamino)propylaminomethyl]benzene Investigative 44315610 C30H36N10O4 600.7 C1=CC(=CC=C1CNC(=O)CC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CC(=O)NCC3=CC=C(C=C3)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BSYN97 4-[2-(3-Benzenesulfonylamino-phenoxy)-ethylamino]-pyridinium Investigative 15227967 C19H19N3O3S 369.4 C1=CC=C(C=C1)S(=O)(=O)NC2=CC(=CC=C2)OCCNC3=CC=NC=C3 Ki > 500000 nM Non binder T89034 Plasminogen BT40PV (2S)-N-[(2S)-5-(Diaminomethylideneamino)-2-methyl-1-oxopentan-2-yl]-1-[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]pyrrolidine-2-carboxamide Investigative 44358866 C22H32N6O3 428.5 C[C@](CCCN=C(N)N)(C=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CC3=CC=CC=C3CN2 IC50 = 740000 nM Non binder T89034 Plasminogen BTC93D 1,4-Bis[[2-oxo-2-(4-guanidinobenzylamino)ethyl]carbamoyloxymethyl]benzene Investigative 44315844 C30H36N10O6 632.7 C1=CC(=CC=C1CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3=CC=C(C=C3)N=C(N)N)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BTO2K6 4-(Hydroxymethyl)benzamidine Investigative 448513 C8H10N2O 150.18 C1=CC(=CC=C1CO)C(=N)N Ki = 630957.34 nM Non binder T89034 Plasminogen BTRI91 4-(2-Hydroxyethylamino)-pyridine Investigative 17750368 C7H10N2O 138.17 C1=CN=CC=C1NCCO Ki > 500000 nM Non binder T89034 Plasminogen BU2T4G 2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester Investigative 44287797 C19H24ClN3O4S 425.9 CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCCN=C(N)N Ki > 200000 nM Non binder T89034 Plasminogen BU37NM 3,5-Dimethylbenzenecarboximidamide Investigative 3357702 C9H12N2 148.2 CC1=CC(=CC(=C1)C(=N)N)C Ki = 251188.64 nM Non binder T89034 Plasminogen BU7X8W 1H-Indole-5-carboximidamide, 1-ethyl- Investigative 28742032 C11H13N3 187.24 CCN1C=CC2=C1C=CC(=C2)C(=N)N Ki > 400000 nM Non binder T89034 Plasminogen BU81YN N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-5-guanidinopentanamide Investigative 53323948 C18H30N12O 430.5 C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NC(=O)CCCCN=C(N)N)/C(=N/N=C(N)N)/C Ki = 1000000 nM Non binder T89034 Plasminogen BUHW20 N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-[4-(2-amino-2-oxoethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655496 C26H29N9O5 547.6 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=C(C=C4)OCC(=O)N IC50 = 400000 nM Non binder T89034 Plasminogen BUS19I 1beta,5beta-Bis[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane Investigative 44315913 C34H60N8O6 676.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5 Ki > 1000000 nM Non binder T89034 Plasminogen BV0UD4 1,4-Bis[[(R)-1-methyl-2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene Investigative 44316049 C32H40N6O6 604.7 C[C@H](C(=O)NCC1=CC=C(C=C1)CN)NC(=O)OCC2=CC=C(C=C2)COC(=O)N[C@H](C)C(=O)NCC3=CC=C(C=C3)CN Ki > 1000000 nM Non binder T89034 Plasminogen BV3U9R N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(3-cyanophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655494 C25H25N9O3 499.5 CN1C(=CC2=CN=C(N=C21)C(=O)N[C@@H](CCCCN)C#N)CN3C(=O)CN(C3=O)C4=CC=CC(=C4)C#N IC50 = 220000 nM Non binder T89034 Plasminogen BV54EL 2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide Investigative 44459496 C26H31N5O4S 509.6 C1CCN(CC1)C(=O)[C@H](CCNC2=CC=NC=C2)NC(=O)CNS(=O)(=O)C3=CC4=CC=CC=C4C=C3 Ki > 500000 nM Non binder T89034 Plasminogen BVLI64 N-[(1S)-5-Amino-1-cyanopentyl]-7-methyl-6-[(3-methyl-2,5-dioxoimidazolidin-1-yl)methyl]pyrrolo[2,3-d]pyrimidine-2-carboxamide Investigative 90655485 C19H24N8O3 412.4 CN1CC(=O)N(C1=O)CC2=CC3=CN=C(N=C3N2C)C(=O)N[C@@H](CCCCN)C#N IC50 > 1000000 nM Non binder T89034 Plasminogen BW17DK {2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester Investigative 44337899 C24H38N6O4 474.6 CC(C)(C)OC(=O)N[C@@H](CN1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O)C2=CC=CC=C2 IC50 = 400000 nM Non binder T89034 Plasminogen BW73KZ [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate Investigative 9875345 C36H52N12O6 748.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N Ki = 494000 nM Non binder T89034 Plasminogen BWFB16 3-(4-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester Investigative 10695159 C21H23N5O5S 457.5 CCOC(=O)C(CC1=CC=C(C=C1)C(=N)N)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C#N Ki > 1000000 nM Non binder T89034 Plasminogen BWJ92U 1beta,5beta-Bis[4-[4-(2-aminoethyl)phenylacetyl]piperazinocarbonyloxy]cyclooctane Investigative 18397350 C38H54N6O6 690.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3=CC=C(C=C3)CCN)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)CCN Ki > 1000000 nM Non binder T89034 Plasminogen BXNG21 Boc-D-Ser-Gly-(4-Amidinobenzyl)NH2 Investigative 44372738 C18H27N5O5 393.4 CC(C)(C)OC(=O)N[C@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BY3B4R 1,4-Bis[[3-oxo-3-(4-guanidinobenzylamino)propyl]carbamoyloxymethyl]benzene Investigative 44315843 C32H40N10O6 660.7 C1=CC(=CC=C1CNC(=O)CCNC(=O)OCC2=CC=C(C=C2)COC(=O)NCCC(=O)NCC3=CC=C(C=C3)N=C(N)N)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BY6S4B (3Aalpha,6aalpha)-2beta,5beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]octahydropentalene Investigative 44315678 C36H50N12O6 746.9 C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)OC3CC4CC(CC4C3)OC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen BY7Z4D 1H-Indole-6-carboximidamide, 3-acetyl- Investigative 44331989 C11H11N3O 201.22 CC(=O)C1=CNC2=C1C=CC(=C2)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BYF65K 2-Amino-N-[(4-carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-propionamide Investigative 9922130 C13H19N5O3 293.32 C1=CC(=CC=C1CNC(=O)CNC(=O)[C@H](CO)N)C(=N)N Ki > 1000000 nM Non binder T89034 Plasminogen BYTF26 4-Nitrobenzamidine Investigative 117475 C7H7N3O2 165.15 C1=CC(=CC=C1C(=N)N)[N+](=O)[O-] Ki = 3981071.71 nM Non binder T89034 Plasminogen BYVP36 [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(pyridin-4-ylamino)propanoyl]piperazine-1-carboxylate Investigative 44316015 C35H50N10O6 706.8 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCNC5=CC=NC=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BZ3T9W 2-Benzenesulfonylamino-N-[(R)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide Investigative 44459377 C22H29N5O4S 459.6 C1CCN(CC1)C(=O)[C@@H](CCNC2=CC=NC=C2)NC(=O)CNS(=O)(=O)C3=CC=CC=C3 Ki > 500000 nM Non binder T89034 Plasminogen BZ56DU (2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)pent-4-ynamide Investigative 10345602 C28H35N3O3S 493.7 CNC1=CC=C(C=C1)C#CC[C@@H](C(=O)N(C)C2CCCC2)NS(=O)(=O)C3=CC4=C(CCCC4)C=C3 Ki > 200000 nM Non binder T89034 Plasminogen BZ8Q2B [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-pyridin-4-ylsulfanylpropanoyl)piperazine-1-carboxylate Investigative 44315912 C35H49N9O6S 723.9 C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCSC5=CC=NC=C5 Ki > 1000000 nM Non binder T89034 Plasminogen BZYL38 (8e)-3-Amino-1-Methyl-15-[(1h-Pyrazol-1-Yl)methyl]-7,10,11,12,24,25-Hexahydro-6h,18h,23h-19,22-(Metheno)pyrido[4,3-J][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-One Investigative 134131589 C29H33N7O3 527.6 CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCCC/C=C/CCOC2=CC(=N1)N)N=C3 IC50 > 200000 nM Non binder T89034 Plasminogen D07SFI Benzamidine Investigative 2332 C7H8N2 120.15 C1=CC=C(C=C1)C(=N)N Ki = 350000 nM Non binder T89034 Plasminogen D08OCL 4-(5-Nitro-indol-1-ylmethyl)-benzamidine Investigative 44331823 C16H14N4O2 294.31 C1=CC(=CC=C1CN2C=CC3=C2C=CC(=C3)[N+](=O)[O-])C(=N)N Ki > 400000 nM Non binder T89034 Plasminogen D0F6EZ (4-guanidino-benzyl)-carbamic acid benzyl ester Investigative 44436702 C16H18N4O2 298.34 C1=CC=C(C=C1)COC(=O)NCC2=CC=C(C=C2)N=C(N)N Ki > 1000000 nM Non binder T89034 Plasminogen D0M2PE 1-Benzyl-1H-indole-5-carboxamidine Investigative 29012033 C16H15N3 249.31 C1=CC=C(C=C1)CN2C=CC3=C2C=CC(=C3)C(=N)N Ki = 844000 nM Non binder