Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07UWV
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| Former ID |
DAP000758
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| Drug Name |
Argatroban
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| Synonyms |
Acova; Argatrobanum; MMTQAP; MPQA; Novastan; Argatrobanum [Latin]; MITSUBISHI INHIBITOR; MCI 9038; MD 805; MD805; Argatroban (anhydrous); Argatroban [INN:JAN]; GN-1600; MCI-9038; MD-805; MQI-ARG-MCP; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-4-Methyl-1-((S)-N(sup 2)-(((RS)-1,2,3,4-tetrahydro-3-methyl-8-quinolyl)sulfonyl)arginyl)pipecolic acid; (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl)]-2-piperadinecarboxylic acid; (2r,4r)-4-methyl-1-[n2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-l-arginyl]-2-piperidinecarboxylic acid; 21R-Argatroban; 4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Approved | [1], [2] | |
| Therapeutic Class |
Anticoagulants
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| Structure |
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Download2D MOL |
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| Formula |
C23H36N6O5S
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| Canonical SMILES |
CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C
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| InChI |
1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1
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| InChIKey |
KXNPVXPOPUZYGB-IOVMHBDKSA-N
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| CAS Number |
CAS 74863-84-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14786817, 14786818, 26719855, 44423523, 46386718, 49681688, 50015606, 50111795, 76329972, 87225383, 92308497, 92309228, 103072462, 103079898, 103339406, 103945452, 104408187, 117541869, 123120899, 124658931, 125311690, 126664536, 128449126, 135062360, 136379666, 152059031, 152212228, 160814640, 162011683, 162178885, 162254934, 163089948, 163670117, 164788049, 172080306, 174006836, 174473281, 174530566, 175607554, 176484535, 178103001, 179116564, 179295943, 179323694, 184643919, 184816446, 198993723, 203355751, 204433880, 210279520
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| ChEBI ID |
CHEBI:94385
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| ADReCS Drug ID | BADD_D00161 | |||
| SuperDrug ATC ID |
B01AE03
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| SuperDrug CAS ID |
cas=074863846
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6385). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation. J Biol Chem. 2002 Dec 27;277(52):50439-44. | |||
| REF 4 | New anticoagulants. Am Heart J. 2001 Aug;142(2 Suppl):S3-8. | |||
| REF 5 | Enzyme-controlling medicines: introduction. Semin Thromb Hemost. 1997;23(6):493-501. | |||
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