Patent(s) and the Corresponding Patented Drug(s) |
Top |
United States Patent and Trademark Office (USPTO) |
Patent ID |
US9598426 |
Title |
Organic compounds |
Abstract |
Provided are PDE1 inhibitors of Formula I, processes for their production and their use as pharmaceuticals, and pharmaceutical compositions comprising them. |
Applicant(s) |
INTRA-CELLULAR THERAPIES, INC. |
Representative Drug(s) |
D0E9JC |
Drug Info
|
N.A. |
Click to Show More |
[1] |
2
|
D0Z1CK
|
Drug Info
|
N.A.
|
[1] |
3
|
D0HO1Q
|
Drug Info
|
N.A.
|
[1] |
Patent ID |
US9598426 |
Title |
Organic compounds |
Abstract |
Provided are PDE1 inhibitors of Formula I, processes for their production and their use as pharmaceuticals, and pharmaceutical compositions comprising them. |
Applicant(s) |
INTRA-CELLULAR THERAPIES, INC. |
Representative Drug(s) |
D0E9JC |
Drug Info
|
N.A. |
Click to Show More |
[1] |
2
|
D0Z1CK
|
Drug Info
|
N.A.
|
[1] |
3
|
D0HO1Q
|
Drug Info
|
N.A.
|
[1] |
Patent ID |
US9598426 |
Title |
Organic compounds |
Abstract |
Provided are PDE1 inhibitors of Formula I, processes for their production and their use as pharmaceuticals, and pharmaceutical compositions comprising them. |
Applicant(s) |
INTRA-CELLULAR THERAPIES, INC. |
Representative Drug(s) |
D0E9JC |
Drug Info
|
N.A. |
Click to Show More |
[1] |
2
|
D0Z1CK
|
Drug Info
|
N.A.
|
[1] |
3
|
D0HO1Q
|
Drug Info
|
N.A.
|
[1] |
Patent ID |
US9173884 |
Title |
Inhibitors of phosphodiesterase 11 (PDE11) |
Abstract |
The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject. |
Applicant(s) |
Trustees of Boston College |
Patent ID |
US9173884 |
Title |
Inhibitors of phosphodiesterase 11 (PDE11) |
Abstract |
The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject. |
Applicant(s) |
Trustees of Boston College |
Patent ID |
US9173884 |
Title |
Inhibitors of phosphodiesterase 11 (PDE11) |
Abstract |
The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject. |
Applicant(s) |
Trustees of Boston College |
Patent ID |
US9173884 |
Title |
Inhibitors of phosphodiesterase 11 (PDE11) |
Abstract |
The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject. |
Applicant(s) |
Trustees of Boston College |
Patent ID |
US10105367 |
Title |
Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones |
Abstract |
Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders. |
Applicant(s) |
DART NEUROSCIENCE (CAYMAN) LTD. |
Representative Drug(s) |
D0WS3T |
Drug Info
|
IC50 < 100nM |
[3] |
Patent ID |
US10092575 |
Title |
Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds |
Abstract |
Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders. |
Applicant(s) |
Dart NeuroScience (Cayman) Ltd. |
Representative Drug(s) |
D0NI7A |
Drug Info
|
N.A. |
Click to Show More |
[4] |
2
|
D03GTM
|
Drug Info
|
N.A.
|
[4] |
3
|
D0J1LK
|
Drug Info
|
N.A.
|
[4] |
Patent ID |
US10092575 |
Title |
Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds |
Abstract |
Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders. |
Applicant(s) |
Dart NeuroScience (Cayman) Ltd. |
Representative Drug(s) |
D0NI7A |
Drug Info
|
N.A. |
Click to Show More |
[4] |
2
|
D03GTM
|
Drug Info
|
N.A.
|
[4] |
3
|
D0J1LK
|
Drug Info
|
N.A.
|
[4] |
Patent ID |
US10092575 |
Title |
Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds |
Abstract |
Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders. |
Applicant(s) |
Dart NeuroScience (Cayman) Ltd. |
Representative Drug(s) |
D0NI7A |
Drug Info
|
N.A. |
Click to Show More |
[4] |
2
|
D03GTM
|
Drug Info
|
N.A.
|
[4] |
3
|
D0J1LK
|
Drug Info
|
N.A.
|
[4] |
Patent ID |
US10034861 |
Title |
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
Abstract |
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. |
Applicant(s) |
H. Lundbeck A/S |
Representative Drug(s) |
D06WJK |
Drug Info
|
IC50 = 1.6 nM |
Click to Show More |
[5] |
2
|
D0V8ZY
|
Drug Info
|
IC50 = 1.6 nM
|
[5] |
3
|
D00LVD
|
Drug Info
|
IC50 = 5.9 nM
|
[5] |
Patent ID |
US10034861 |
Title |
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
Abstract |
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. |
Applicant(s) |
H. Lundbeck A/S |
Representative Drug(s) |
D06WJK |
Drug Info
|
IC50 = 1.6 nM |
Click to Show More |
[5] |
2
|
D0V8ZY
|
Drug Info
|
IC50 = 1.6 nM
|
[5] |
3
|
D00LVD
|
Drug Info
|
IC50 = 5.9 nM
|
[5] |
Patent ID |
US10034861 |
Title |
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
Abstract |
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. |
Applicant(s) |
H. Lundbeck A/S |
Representative Drug(s) |
D06WJK |
Drug Info
|
IC50 = 1.6 nM |
Click to Show More |
[5] |
2
|
D0V8ZY
|
Drug Info
|
IC50 = 1.6 nM
|
[5] |
3
|
D00LVD
|
Drug Info
|
IC50 = 5.9 nM
|
[5] |