Target Validation Information
Target ID T09909
Target Name Type-2 angiotensin II receptor
Target Type
Successful
Drug Potency against Target SC-55634 Drug Info IC50 = 4.9 nM
SC-51895 Drug Info IC50 = 12 nM
Sar-Arg-Val-Tyr-Ile-His-Pro-Ile Drug Info IC50 = 0.1 nM [530232]
PD-123319 Drug Info IC50 = 210 nM [530232]
Macrocyclic Quinazolinone analogue Drug Info IC50 = 20 nM
L-158809 Drug Info IC50 = 37 nM
L-158282 Drug Info IC50 = 3 nM
L-162313 Drug Info IC50 = 2 nM [530937]
Sar-Arg-Val-Tyr-Ile-His-Pro-Ala Drug Info IC50 = 5.1 nM [530232]
SC-50560 Drug Info IC50 = 5.6 nM
L-162234 Drug Info IC50 = 0.45 nM [525772]
L-159689 Drug Info IC50 = 0.7 nM
L-159093 Drug Info IC50 = 4500 nM [533939]
Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH Drug Info IC50 = 1.3 nM [530734]
ANGIOTENSIN II Drug Info IC50 = 2 nM
Forasartan Drug Info IC50 = 6.9 nM
SARALASIN Drug Info Ki = 0.15 nM [529789]
SC-52892 Drug Info IC50 = 6.5 nM
References
Ref 530232J Med Chem. 1991 Nov;34(11):3248-60.Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Ref 530232J Med Chem. 1991 Nov;34(11):3248-60.Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Ref 530937Bioorg Med Chem. 2010 Jun 15;18(12):4570-90. Epub 2010 Apr 9.Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition.
Ref 530232J Med Chem. 1991 Nov;34(11):3248-60.Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Ref 525772J Med Chem. 2000 May 18;43(10):1993-2006.Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.
Ref 533939J Med Chem. 1993 Oct 15;36(21):3207-10.A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.
Ref 530734J Med Chem. 1991 Apr;34(4):1514-7.1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
Ref 529789J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.