Drug General Information
Drug ID	D0MI0T
Former ID	DNC012700
Drug Name	Macrocyclic Quinazolinone analogue
Indication	Discovery agent		Investigative	[551315]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Type-2 angiotensin II receptor	Target Info	Inhibitor	[551315]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Renin-angiotensin system
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551315	The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996).
Ref 551315	The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996).

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