TTD | Drug: D0GS7N

Drug General Information
Drug ID	D0GS7N
Former ID	DNC011714
Drug Name	L-158809
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[544926]
Structure		Download 2D MOL 3D MOL
Formula	C24H23N7
Canonical SMILES	CCC1=NC2=C(N1C3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=C(C=C2<br />C)C
InChI	1S/C23H21N7/c1-4-20-25-21-14(2)13-15(3)24-23(21)30(20)17-11-9-16(10-12-17)18-7-5-6-8-19(18)22-26-28-29-27-22/h5-13H,4H2,1-3H3,(H,26,27,28,29)
InChIKey	ZXLFZNWBWMYLDB-UHFFFAOYSA-N
PubChem Compound ID	183134
Target and Pathway
Target(s)	Type-2 angiotensin II receptor	Target Info	Inhibitor	[551261]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Renin-angiotensin system
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544926	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001562)
Ref 551261	Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).

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Drug Information