TTD | Drug: D04AOA

Drug General Information
Drug ID	D04AOA
Former ID	DNC012760
Drug Name	SC-51895
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[545549]
Structure		Download 2D MOL 3D MOL
Formula	C25H30N6O
Canonical SMILES	CCCCC1=CN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CCC<br />C
InChI	1S/C25H30N6O/c1-3-5-9-21-18-30(16-6-4-2)25(32)31(21)17-19-12-14-20(15-13-19)22-10-7-8-11-23(22)24-26-28-29-27-24/h7-8,10-15,18H,3-6,9,16-17H2,1-2H3,(H,26,27,28,29)
InChIKey	JYOGXGMOSXSRMV-UHFFFAOYSA-N
PubChem Compound ID	9954408
Target and Pathway
Target(s)	Type-2 angiotensin II receptor	Target Info	Inhibitor	[551257]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Renin-angiotensin system
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545549	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003677)
Ref 551257	N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists, Bioorg. Med. Chem. Lett. 3(6):1055-1060 (1993).

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Drug Information