Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T35527
|
||||
Former ID |
TTDR00239
|
||||
Target Name |
Arachidonate 12-lipoxygenase, 12S-type
|
||||
Gene Name |
ALOX12
|
||||
Synonyms |
12-LOX; 12-lipoxygenase; Platelet-type lipoxygenase 12; ALOX12
|
||||
Target Type |
Discontinued
|
||||
Function |
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
|
||||
BioChemical Class |
Oxidoreductases acting on single donors
|
||||
Target Validation |
T35527
|
||||
UniProt ID | |||||
EC Number |
EC 1.13.11.31
|
||||
Sequence |
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS VTI |
||||
Drugs and Mode of Action | |||||
Inhibitor | (+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol | Drug Info | [526556] | ||
(+)-(5S,8S,10S)-20-methoxypuupehenol | Drug Info | [526556] | |||
(+)-(5S,8S,9R,10S)-20-methoxypuupehenone | Drug Info | [526556] | |||
(-)-7-N-methyldibromophakellin | Drug Info | [527187] | |||
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol | Drug Info | [527145] | |||
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol | Drug Info | [527145] | |||
CHLOROPUUPEHENONE | Drug Info | [526556] | |||
Dimethylnordihydroguarierate acid | Drug Info | [526556] | |||
DYSIDENIN | Drug Info | [529029] | |||
Isojaspic acid | Drug Info | [530468] | |||
Jaspic acid | Drug Info | [526556] | |||
NEODYSIDENIN | Drug Info | [529029] | |||
NSC-125034 | Drug Info | [529029] | |||
NSC-172033 | Drug Info | [529029] | |||
NSC-292213 | Drug Info | [529029] | |||
NSC-30552 | Drug Info | [529029] | |||
NSC-661755 | Drug Info | [529029] | |||
Polybrominated diphenyl ether derivative | Drug Info | [527145] | |||
PUUPEHEDIONE | Drug Info | [530468] | |||
PUUPEHENONE | Drug Info | [526556] | |||
Pathways | |||||
BioCyc Pathway | Lipoxin biosynthesis | ||||
KEGG Pathway | Arachidonic acid metabolism | ||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channels | |||||
PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
WikiPathways | Arachidonic acid metabolism | ||||
Eicosanoid Synthesis | |||||
References | |||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 527145 | J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. | ||||
Ref 527187 | J Nat Prod. 2004 Aug;67(8):1256-61.An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.