Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07BXV
|
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| Former ID |
DNC009195
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| Drug Name |
PUUPEHENONE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H28O3
|
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| Canonical SMILES |
CC1(CCCC2(C1CCC3(C2C=C4C=C(C(=O)C=C4O3)O)C)C)C
|
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| InChI |
1S/C21H28O3/c1-19(2)7-5-8-20(3)17(19)6-9-21(4)18(20)11-13-10-14(22)15(23)12-16(13)24-21/h10-12,17-18,22H,5-9H2,1-4H3/t17-,18+,20-,21-/m0/s1
|
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| InChIKey |
LOCMLXSTDCXZFJ-YHELAOLJSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | mRNA of human 5-lipoxygenase | Target Info | Inhibitor | [1] | |
| Arachidonate 15-lipoxygenase | Target Info | Inhibitor | [1] | ||
| Arachidonate 12-lipoxygenase, 12S-type | Target Info | Inhibitor | [2] | ||
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesisPWY66-397:Resolvin D biosynthesis | |||||
| Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosishsa00590:Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| Serotonergic synapsehsa00590:Arachidonic acid metabolism | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL4 Signaling PathwayNetPath_16:IL4 Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| PathWhiz Pathway | Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism | ||||
| WikiPathways | Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism | |||||
| Eicosanoid SynthesisWP2650:Arachidonic acid metabolism | |||||
| References | |||||
| REF 1 | J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. | ||||
| REF 2 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
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