| Drug General Information |
| Drug ID |
D05FJM
|
| Former ID |
DNC010933
|
| Drug Name |
PUUPEHEDIONE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H26O3
|
| Canonical SMILES |
CC1(CCCC2(C1CCC3(C2=CC4=CC(=O)C(=O)C=C4O3)C)C)C
|
| InChI |
1S/C21H26O3/c1-19(2)7-5-8-20(3)17(19)6-9-21(4)18(20)11-13-10-14(22)15(23)12-16(13)24-21/h10-12,17H,5-9H2,1-4H3/t17-,20-,21-/m0/s1
|
| InChIKey |
QLFLHSQZFRDPFM-YYWHXJBOSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of human 5-lipoxygenase |
Target Info |
Inhibitor |
[1]
|
|---|
| Arachidonate 15-lipoxygenase |
Target Info |
Inhibitor |
[1]
|
| Arachidonate 12-lipoxygenase, 12S-type |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
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Leukotriene biosynthesis
|
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Lipoxin biosynthesis
|
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Aspirin triggered resolvin D biosynthesis
|
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Aspirin triggered resolvin E biosynthesisPWY66-397:Resolvin D biosynthesis
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Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis
|
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KEGG Pathway
|
Arachidonic acid metabolism
|
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Metabolic pathways
|
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Serotonergic synapse
|
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Ovarian steroidogenesis
|
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Toxoplasmosishsa00590:Arachidonic acid metabolism
|
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Linoleic acid metabolism
|
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Serotonergic synapsehsa00590:Arachidonic acid metabolism
|
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Inflammatory mediator regulation of TRP channels
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NetPath Pathway
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IL4 Signaling PathwayNetPath_16:IL4 Signaling Pathway
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
|
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Pathway Interaction Database
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IL4-mediated signaling events
|
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PathWhiz Pathway
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Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
|
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WikiPathways
|
Arachidonic acid metabolism
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Eicosanoid Synthesis
|
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Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism
|
|
Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
|
| References |
| REF 1 | J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. |
|---|
