Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02ZPE
|
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| Former ID |
DNC007821
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| Drug Name |
NSC-30552
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C24H26O6
|
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| Canonical SMILES |
CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C<br />)C)O)C
|
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| InChI |
1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
|
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| InChIKey |
GNRIZKKCNOBBMO-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Arachidonate 12-lipoxygenase, 12S-type | Target Info | Inhibitor | [1] | |
| Arachidonate 15-lipoxygenase | Target Info | Inhibitor | [1] | ||
| BioCyc Pathway | Lipoxin biosynthesisPWY66-397:Resolvin D biosynthesis | ||||
| Lipoxin biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channelshsa00590:Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| PathWhiz Pathway | Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism | ||||
| WikiPathways | Arachidonic acid metabolism | ||||
| Eicosanoid SynthesisWP2650:Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. | ||||
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