Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T10091
|
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| Former ID |
TTDR00221
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| Target Name |
Rhodopsin
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| Gene Name |
RHO
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| Synonyms |
Opsin-2; RHO
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| Target Type |
Research
|
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| Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
| Function |
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
|
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| BioChemical Class |
GPCR rhodopsin
|
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| Target Validation |
T10091
|
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| UniProt ID | |||||
| Sequence |
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAI YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA |
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| Inhibitor | (Hydroxyethyloxy)Tri(Ethyloxy)Octane | Drug Info | [1] | ||
| Alpha-D-Mannose | Drug Info | [1] | |||
| B-2-Octylglucoside | Drug Info | [1] | |||
| B-Nonylglucoside | Drug Info | [2] | |||
| B-Octylglucoside | Drug Info | [1] | |||
| Beta-D-Mannose | Drug Info | [1] | |||
| Heptane-1,2,3-Triol | Drug Info | [1] | |||
| Heptyl 1-Thiohexopyranoside | Drug Info | [2] | |||
| Hexadecanal | Drug Info | [3] | |||
| Lauryl Dimethylamine-N-Oxide | Drug Info | [1] | |||
| N-Acetylmethionine | Drug Info | [2] | |||
| NSC-88915 | Drug Info | [4] | |||
| Palmitic Acid | Drug Info | [1] | |||
| Phosphonoserine | Drug Info | [1] | |||
| Phosphonothreonine | Drug Info | [1] | |||
| Pathways | |||||
| KEGG Pathway | Phototransduction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | ||||
| Pathway Interaction Database | Rods | ||||
| Reactome | The canonical retinoid cycle in rods (twilight vision) | ||||
| Inactivation, recovery and regulation of the phototransduction cascade | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Visual phototransduction | |||||
| Regulation of Microtubule Cytoskeleton | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrin-mediated Cell Adhesion | |||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 3 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
| REF 4 | J Med Chem. 2008 Sep 11;51(17):5297-303. Epub 2008 Aug 16.Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. | ||||
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