| Drug General Information |
| Drug ID |
D05BHG
|
| Former ID |
DNC002812
|
| Drug Name |
Phosphonothreonine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C4H10NO6P
|
| Canonical SMILES |
CC(C(C(=O)O)N)OP(=O)(O)O
|
| InChI |
1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10)/t2-,3+/m1/s1
|
| InChIKey |
USRGIUJOYOXOQJ-GBXIJSLDSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14294, 825557, 7890851, 11564534, 24710793, 24898147, 34611601, 49836632, 57570938, 76834844, 91701989, 111871183, 117393471, 126529769, 129414926, 132520520, 134979445, 137182204, 138390728, 138458696, 162160767, 162160770, 162249571, 162497134, 184816426, 202556746, 226427346, 252377767, 252502914
|
| Target and Pathway |
| Target(s) |
Aurora kinase A |
Target Info |
Inhibitor |
[1]
|
|---|
| Cell division protein kinase 7 |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C, theta type |
Target Info |
Inhibitor |
[1]
|
| Mitogen-activated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
| Rhodopsin |
Target Info |
Inhibitor |
[1]
|
| MAP kinase p38 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Oocyte meiosishsa03022:Basal transcription factors
|
|
Nucleotide excision repair
|
|
Cell cyclehsa04064:NF-kappa B signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Tight junction
|
|
T cell receptor signaling pathway
|
|
Inflammatory mediator regulation of TRP channels
|
|
Adipocytokine signaling pathway
|
|
Measleshsa04010:MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Chemokine signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Oocyte meiosis
|
|
mTOR signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Adrenergic signaling in cardiomyocytes
|
|
Dorso-ventral axis formation
|
|
TGF-beta signaling pathway
|
|
Axon guidance
|
|
VEGF signaling pathway
|
|
Osteoclast differentiation
|
|
Focal adhesion
|
|
Adherens junction
|
|
Gap junction
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Platelet activation
|
|
Toll-like receptor signaling pathway
|
|
NOD-like receptor signaling pathway
|
|
Natural killer cell mediated cytotoxicity
|
|
B cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
TNF signaling pathway
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Neurotrophin signaling pathway
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Cholinergic synapse
|
|
Serotonergic synapse
|
|
Long-term depression
|
|
Regulation of actin cytoskeleton
|
|
Insulin signaling pathway
|
|
GnRH signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
Estrogen signaling pathway
|
|
Melanogenesis
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Type II diabetes mellitus
|
|
Aldosterone-regulated sodium reabsorption
|
|
Alzheimer's disease
|
|
Prion diseases
|
|
Alcoholism
|
|
Shigellosis
|
|
Salmonella infection
|
|
Pertussis
|
|
Leishmaniasis
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis C
|
|
Hepatitis B
|
|
Influenza A
|
|
Pathways in cancer
|
|
Viral carcinogenesis
|
|
Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
Colorectal cancer
|
|
Renal cell carcinoma
|
|
Pancreatic cancer
|
|
Endometrial cancer
|
|
Glioma
|
|
Prostate cancer
|
|
Thyroid cancer
|
|
Melanoma
|
|
Bladder cancer
|
|
Chronic myeloid leukemia
|
|
Acute myeloid leukemia
|
|
Non-small cell lung cancer
|
|
Central carbon metabolism in cancer
|
|
Choline metabolism in cancerhsa04744:Phototransductionhsa04010:MAPK signaling pathway
|
|
RIG-I-like receptor signaling pathway
|
|
Leukocyte transendothelial migration
|
|
Dopaminergic synapse
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Epstein-Barr virus infection
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
RANKL Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
|
Apoptosis signaling pathway
|
|
EGF receptor signaling pathway
|
|
Endothelin signaling pathway
|
|
FGF signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
T cell activation
|
|
VEGF signaling pathway
|
|
Wnt signaling pathway
|
|
5HT2 type receptor mediated signaling pathway
|
|
Histamine H1 receptor mediated signaling pathway
|
|
Oxytocin receptor mediated signaling pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathway
|
|
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
|
|
B cell activation
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Interferon-gamma signaling pathway
|
|
Interleukin signaling pathway
|
|
PDGF signaling pathway
|
|
Parkinson disease
|
|
TGF-beta signaling pathway
|
|
Ras Pathway
|
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
CCKR signaling map STP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00003:Alzheimer disease-amyloid secretase pathway
|
|
Oxidative stress response
|
|
p53 pathway feedback loops 2
|
|
p38 MAPK pathway
|
|
Pathway Interaction Database
|
Aurora B signaling
|
|
Signaling by Aurora kinases
|
|
Integrin-linked kinase signaling
|
|
PLK1 signaling events
|
|
Aurora A signalingretinoic_acid_pathway:Retinoic acid receptors-mediated signalingendothelinpathway:Endothelins
|
|
TCR signaling in naï
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
TCR signaling in naï
|
|
Thromboxane A2 receptor signaling
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
Downstream signaling in naï
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
BCR signaling pathway
|
|
Signaling events mediated by PRL
|
|
ErbB4 signaling events
|
|
GMCSF-mediated signaling events
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
S1P3 pathway
|
|
EPHB forward signaling
|
|
Osteopontin-mediated events
|
|
S1P4 pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
TRAIL signaling pathway
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
S1P1 pathway
|
|
Regulation of Telomerase
|
|
Netrin-mediated signaling events
|
|
Glucocorticoid receptor regulatory network
|
|
Arf6 downstream pathway
|
|
mTOR signaling pathway
|
|
Class IB PI3K non-lipid kinase events
|
|
IL2-mediated signaling events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Ras signaling in the CD4+ TCR pathway
|
|
Ceramide signaling pathway
|
|
Integrins in angiogenesis
|
|
IFN-gamma pathway
|
|
ErbB1 downstream signaling
|
|
ATF-2 transcription factor network
|
|
ErbB2/ErbB3 signaling events
|
|
BMP receptor signaling
|
|
ALK1 signaling events
|
|
PDGFR-beta signaling pathway
|
|
Neurotrophic factor-mediated Trk receptor signaling
|
|
Syndecan-1-mediated signaling events
|
|
Retinoic acid receptors-mediated signaling
|
|
Nongenotropic Androgen signaling
|
|
CXCR3-mediated signaling events
|
|
VEGFR1 specific signals
|
|
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Syndecan-2-mediated signaling events
|
|
Cellular roles of Anthrax toxin
|
|
S1P2 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
Alpha-synuclein signaling
|
|
FGF signaling pathway
|
|
Signaling events mediated by focal adhesion kinaserhodopsin_pathway:Visual signal transduction: Rodsrhoa_pathway:RhoA signaling pathway
|
|
Signaling mediated by p38-gamma and p38-delta
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Insulin Signalling
|
|
Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Regulation of PLK1 Activity at G2/M TransitionR-HSA-427413:NoRC negatively regulates rRNA expression
|
|
Formation of TC-NER Pre-Incision Complex
|
|
Dual incision in TC-NER
|
|
Gap-filling DNA repair synthesis and ligation in TC-NER
|
|
Cyclin E associated events during G1/S transition
|
|
Cyclin D associated events in G1
|
|
Cyclin A/B1 associated events during G2/M transition
|
|
Cyclin A:Cdk2-associated events at S phase entry
|
|
RNA Polymerase I Transcription InitiationR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Effects of PIP2 hydrolysis
|
|
Inactivation, recovery and regulation of the phototransduction cascade
|
|
FCERI mediated NF-kB activation
|
|
G alpha (z) signalling eventsR-HSA-112409:RAF-independent MAPK1/3 activation
|
|
MAPK1 (ERK2) activation
|
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
|
ERK/MAPK targets
|
|
Regulation of actin dynamics for phagocytic cup formation
|
|
Oxidative Stress Induced Senescence
|
|
Senescence-Associated Secretory Phenotype (SASP)
|
|
Oncogene Induced Senescence
|
|
FCERI mediated MAPK activation
|
|
Regulation of HSF1-mediated heat shock response
|
|
NCAM signaling for neurite out-growth
|
|
Recycling pathway of L1
|
|
CREB phosphorylation through the activation of Ras
|
|
Activation of the AP-1 family of transcription factors
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Negative regulation of FGFR1 signaling
|
|
Negative regulation of FGFR2 signaling
|
|
Negative regulation of FGFR3 signaling
|
|
Negative regulation of FGFR4 signaling
|
|
RHO GTPases Activate WASPs and WAVEs
|
|
RAF/MAP kinase cascade
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
|
Negative regulation of MAPK pathway
|
|
Signal attenuation
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Growth hormone receptor signalingR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
|
|
G alpha (i) signalling eventsR-HSA-168638:NOD1/2 Signaling Pathway
|
|
p38MAPK events
|
|
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
|
CDO in myogenesis
|
|
DSCAM interactions
|
|
VEGFA-VEGFR2 Pathway
|
|
WikiPathways
|
EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Gastric Cancer Network 1
|
|
Integrated Breast Cancer Pathway
|
|
APC/C-mediated degradation of cell cycle proteinsWP45:G1 to S cell cycle control
|
|
Eukaryotic Transcription Initiation
|
|
Cardiac Hypertrophic Response
|
|
S Phase
|
|
HIV Life Cycle
|
|
Nucleotide Excision Repair
|
|
RNA Polymerase II Transcription
|
|
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
|
|
mRNA Capping
|
|
Mitotic G2-G2/M phases
|
|
Mitotic G1-G1/S phases
|
|
MicroRNAs in cardiomyocyte hypertrophyWP69:TCR Signaling Pathway
|
|
Calcium Regulation in the Cardiac Cell
|
|
Insulin Signaling
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Corticotropin-releasing hormone
|
|
Signaling Pathways in Glioblastoma
|
|
miRs in Muscle Cell Differentiation
|
|
TCR signaling
|
|
Netrin-1 signaling
|
|
GPCR downstream signaling
|
|
Effects of PIP2 hydrolysis
|
|
Apoptotic execution phaseWP75:Toll-like receptor signaling pathway
|
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
Vitamin A and Carotenoid Metabolism
|
|
DNA Damage Response (only ATM dependent)
|
|
TCR Signaling Pathway
|
|
ErbB Signaling Pathway
|
|
Hypothetical Network for Drug Addiction
|
|
Senescence and Autophagy in Cancer
|
|
EPO Receptor Signaling
|
|
Regulation of Actin Cytoskeleton
|
|
IL-2 Signaling Pathway
|
|
MAPK Cascade
|
|
IL-4 Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
IL-3 Signaling Pathway
|
|
Bladder Cancer
|
|
MAP kinase activation in TLR cascade
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
RAF/MAP kinase cascade
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
EBV LMP1 signaling
|
|
Signal Transduction of S1P Receptor
|
|
Nifedipine Activity
|
|
Aryl Hydrocarbon Receptor
|
|
PDGF Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Spinal Cord Injury
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
IL-9 Signaling Pathway
|
|
Endothelin Pathways
|
|
IL17 signaling pathway
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Opioid Signalling
|
|
IL-1 signaling pathway
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Signaling by FGFR
|
|
Integrin-mediated Cell Adhesion
|
|
L1CAM interactions
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Heart Development
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Osteopontin Signaling
|
|
IL-5 Signaling PathwayWP455:GPCRs, Class A Rhodopsin-like
|
|
Visual phototransduction
|
|
Regulation of Microtubule Cytoskeleton
|
|
Integrin-mediated Cell AdhesionWP75:Toll-like receptor signaling pathway
|
|
Parkinsons Disease Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Myogenesis
|
|
DSCAM interactions
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
