Drug Information

Drug General Information
Drug ID
D06PRT
Former ID
DNC002436
Drug Name
Phosphonoserine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL
Formula
C3H8NO6P
Canonical SMILES
C(C(C(=O)O)N)OP(=O)(O)O
InChI
1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey
BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID
68841
PubChem Substance ID
4251, 825453, 841619, 7890432, 7980684, 8145118, 8192381, 11113423, 15340053, 17405445, 24277998, 26751660, 29203220, 43125355, 46505297, 46517825, 47440569, 50068315, 50104360, 50104361, 53777992, 56435316, 56435317, 56435318, 57317099, 57410966, 79764880, 85165191, 85240002, 87574914, 90341677, 91701988, 92298672, 92304275, 103204663, 103843432, 104343198, 117626830, 121361478, 121362097, 124750074, 124886904, 126523129, 127591104, 131331990, 132521938, 135028622, 135651511, 135676490, 136023595
Target and Pathway
Target(s) 3-phosphoinositide dependent protein kinase-1 Target Info Inhibitor [551393]
Phosphomannomutase/phosphoglucomutase Target Info Inhibitor [551393]
Glycogen phosphorylase, muscle form Target Info Inhibitor [551393]
Rhodopsin Target Info Inhibitor [551393]
Protein kinase C, theta type Target Info Inhibitor [551393]
BioCyc Pathway Glycogenolysis
KEGG Pathway PPAR signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Toxoplasmosis
Hepatitis C
Proteoglycans in cancer
Endometrial cancer
Prostate cancer
Non-small cell lung cancer
Choline metabolism in cancerhsa00500:Starch and sucrose metabolism
Metabolic pathways
Glucagon signaling pathwayhsa04744:Phototransductionhsa04064:NF-kappa B signaling pathway
Vascular smooth muscle contraction
Tight junction
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measles
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
p53 pathway
Ras Pathway
p53 pathway feedback loops 2
CCKR signaling map STP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
T cell activation
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database BCR signaling pathway
Insulin Pathway
TCR signaling in na&#xef
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
TCR signaling in na&#xef
FAS (CD95) signaling pathway
mTOR signaling pathway
CXCR4-mediated signaling events
IGF1 pathway
Class I PI3K signaling events
ErbB1 downstream signaling
IL8- and CXCR2-mediated signaling events
CXCR3-mediated signaling events
VEGFR1 specific signals
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Class I PI3K signaling events mediated by Akt
IL8- and CXCR1-mediated signaling events
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathway
TGF-beta receptor signalingrhodopsin_pathway:Visual signal transduction: Rodsendothelinpathway:Endothelins
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Insulin Signalling
Reactome GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin alphaIIb beta3 signaling
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in CancerR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
G alpha (z) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Insulin Signaling
EGF/EGFR Signaling Pathway
Focal Adhesion
Cardiac Hypertrophic Response
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
BDNF signaling pathway
Interleukin-11 Signaling Pathway
B Cell Receptor Signaling Pathway
Signaling Pathways in Glioblastoma
TSH signaling pathway
TCR signaling
Signaling by Insulin receptor
Integrin-mediated Cell Adhesion
GPVI-mediated activation cascade
GPCR downstream signaling
Costimulation by the CD28 family
MicroRNAs in cardiomyocyte hypertrophyWP500:Glycogen Metabolism
Metabolism of carbohydratesWP455:GPCRs, Class A Rhodopsin-like
Visual phototransduction
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Integrin-mediated Cell AdhesionWP69:TCR Signaling Pathway
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
miRs in Muscle Cell Differentiation
Netrin-1 signaling
Effects of PIP2 hydrolysis
Apoptotic execution phase
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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