Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T41141
|
||||
Former ID |
TTDR01031
|
||||
Target Name |
Cathepsin L
|
||||
Gene Name |
CTSL
|
||||
Synonyms |
MEP; Major excreted protein; CTSL
|
||||
Target Type |
Clinical Trial
|
||||
Disease | Asthma [ICD10: J45] | ||||
Coagulation [ICD10: I80-I82] | |||||
Function |
Important for the overall degradation of proteins inlysosomes.
|
||||
BioChemical Class |
Peptidase
|
||||
Target Validation |
T41141
|
||||
UniProt ID | |||||
EC Number |
EC 3.4.22.15
|
||||
Sequence |
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV |
||||
Drugs and Mode of Action | |||||
Inhibitor | (3-Bromobenzoylpyridine)thiosemicarbazone | Drug Info | [531200] | ||
(S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate | Drug Info | [527872] | |||
(S)-tert-butyl 1-oxohexan-2-ylcarbamate | Drug Info | [527872] | |||
1-(1,3-diphenylpropylidene)thiosemicarbazide | Drug Info | [529432] | |||
1-(phenyl(p-tolyl)methylene)thiosemicarbazide | Drug Info | [529432] | |||
6-(benzylamino)-9-butyl-9H-purine-2-carbonitrile | Drug Info | [529240] | |||
9-benzyl-6-(benzylamino)-9H-purine-2-carbonitrile | Drug Info | [529240] | |||
BIPHENYL-4-YL-ACETALDEHYDE | Drug Info | [551374] | |||
Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | Drug Info | [531200] | |||
Bis(3-bromophenyl)(5-hydroxy)thiosemicarbazone | Drug Info | [531200] | |||
Bis(3-Fluorophenyl)-ketone]thiosemicarbazone | Drug Info | [530644] | |||
CAA0225 | Drug Info | [529990] | |||
Cysteinesulfonic Acid | Drug Info | [551393] | |||
KGP94 | Drug Info | [531200] | |||
L-006235-1 | Drug Info | [527882] | |||
L-873724 | Drug Info | [528921] | |||
MDL-2170 | Drug Info | [530104] | |||
N-(4-phenylbenzoyl)-phenylalanyl-glycine-nitrile | Drug Info | [527885] | |||
N-(benzyloxycarbonyl)-leucyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-isoleucyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-leucyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-methionyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-norleucyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-tyrosyl-glycine-nitrile | Drug Info | [527885] | |||
N-(tert-butoxycarbonyl)-valyl-glycine-nitrile | Drug Info | [527885] | |||
N-acetyl-phenylalanyl-glycine-nitrile | Drug Info | [527885] | |||
N-benzoyl-phenylalanyl-glycine-nitrile | Drug Info | [527885] | |||
[(3-Bromophenyl)-m-tolyl-ketone]thiosemicarbazone | Drug Info | [530644] | |||
[(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone | Drug Info | [530644] | |||
[2-Phenylacetophenone]thiosemicarbazone | Drug Info | [531200] | |||
Pathways | |||||
KEGG Pathway | Lysosome | ||||
Phagosome | |||||
Antigen processing and presentation | |||||
Proteoglycans in cancer | |||||
Rheumatoid arthritis | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
Reactome | Endosomal/Vacuolar pathway | ||||
Collagen degradation | |||||
Degradation of the extracellular matrix | |||||
Trafficking and processing of endosomal TLR | |||||
Assembly of collagen fibrils and other multimeric structures | |||||
MHC class II antigen presentation | |||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
References | |||||
Ref 527872 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. Epub 2005 Nov 15.Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?. | ||||
Ref 527882 | J Med Chem. 2005 Dec 1;48(24):7535-43.Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. | ||||
Ref 527885 | J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. | ||||
Ref 528921 | Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. Epub 2007 Jun 10.The identification of potent, selective, and bioavailable cathepsin S inhibitors. | ||||
Ref 529240 | J Med Chem. 2008 Feb 14;51(3):545-52. Epub 2008 Jan 4.Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. | ||||
Ref 529432 | Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. Epub 2008 Apr 8.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. | ||||
Ref 529990 | Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis. Biol Pharm Bull. 2009 Mar;32(3):475-9. | ||||
Ref 530104 | J Med Chem. 2009 May 14;52(9):3093-7.Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. | ||||
Ref 530644 | Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.