Drug Information
Drug General Information | |||||
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Drug ID |
D0U2SS
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Former ID |
DNC004595
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Drug Name |
MDL-2170
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Synonyms |
MDL-28170
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Terminated | [545554] | ||
Structure |
Download2D MOL |
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Formula |
C22H26N2O4
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Canonical SMILES |
CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
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InChI |
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20+/m0/s1
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InChIKey |
NGBKFLTYGSREKK-VQTJNVASSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Calpain | Target Info | Inhibitor | [529828] | |
Cathepsin B | Target Info | Inhibitor | [530104] | ||
Cathepsin L | Target Info | Inhibitor | [530104] | ||
Cysteine protease falcipain-2 | Target Info | Inhibitor | [528208] | ||
Reactome | Degradation of the extracellular matrixR-HSA-1442490:Collagen degradation | ||||
Trafficking and processing of endosomal TLR | |||||
Assembly of collagen fibrils and other multimeric structures | |||||
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
Collagen degradation | |||||
Degradation of the extracellular matrix | |||||
MHC class II antigen presentation | |||||
References | |||||
Ref 528208 | J Med Chem. 2006 Jun 1;49(11):3064-7.Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents. | ||||
Ref 529828 | Bioorg Med Chem Lett. 2009 Jan 15;19(2):502-7. Epub 2008 Nov 14.Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. | ||||
Ref 530104 | J Med Chem. 2009 May 14;52(9):3093-7.Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. |
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