TTD | Drug: D09NBP

Drug General Information
Drug ID	D09NBP
Former ID	DNC011263
Drug Name	(3-Bromobenzoylpyridine)thiosemicarbazone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531200]
Structure		Download 2D MOL 3D MOL
Formula	C13H11BrN4S
Canonical SMILES	C1=CC(=CC(=C1)Br)C(=NNC(=S)N)C2=CN=CC=C2
InChI	1S/C13H11BrN4S/c14-11-5-1-3-9(7-11)12(17-18-13(15)19)10-4-2-6-16-8-10/h1-8H,(H3,15,18,19)/b17-12-
InChIKey	DPTPEKAUCAAQNG-ATVHPVEESA-N
PubChem Compound ID	52940642
Target and Pathway
Target(s)	Cathepsin L	Target Info	Inhibitor	[531200]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Proteoglycans in cancer
	Rheumatoid arthritis
NetPath Pathway	IL4 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Collagen degradation
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 531200	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.
Ref 531200	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

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Drug Information