TTD | Drug: D00VAN

Drug General Information
Drug ID	D00VAN
Former ID	DNC010337
Drug Name	[(3-Bromophenyl)-m-tolyl-ketone]thiosemicarbazone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530644]
Structure		Download 2D MOL 3D MOL
Formula	C15H14BrN3S
Canonical SMILES	CC1=CC=CC(=C1)C(=NNC(=S)N)C2=CC(=CC=C2)Br
InChI	1S/C15H14BrN3S/c1-10-4-2-5-11(8-10)14(18-19-15(17)20)12-6-3-7-13(16)9-12/h2-9H,1H3,(H3,17,19,20)/b18-14+
InChIKey	UUHYYCURIRMTND-NBVRZTHBSA-N
PubChem Compound ID	46232847
Target and Pathway
Target(s)	Cathepsin L	Target Info	Inhibitor	[530644]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Proteoglycans in cancer
	Rheumatoid arthritis
NetPath Pathway	IL4 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Collagen degradation
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 530644	Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Ref 530644	Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.

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Drug Information