Target Information
Target General Infomation | |||||
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Target ID |
T83875
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Former ID |
TTDS00289
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Target Name |
Amine oxidase [flavin-containing] A
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Gene Name |
MAOA
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Synonyms |
MAO-A; Monoamine oxidase; Monoamine oxidase A; MAOA
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Target Type |
Successful
|
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Disease | Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | ||||
Alzheimer disease [ICD9: 331; ICD10: G30] | |||||
Alcohol use disorders [ICD9: 303; ICD10: F10.2] | |||||
Depression [ICD9: 311; ICD10: F30-F39] | |||||
Epilepsy [ICD10: G40] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Mood disorder [ICD10: F30-F39] | |||||
Major depressive episode without melancholia [ICD10: F30-F39] | |||||
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
Parkinson's disease; Major depressive disorder [ICD9:332, 296.2, 296.3, 710.0; ICD10: G20, F32, F33, M32] | |||||
Vitiligo [ICD9: 709.01; ICD10: L80] | |||||
Function |
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
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BioChemical Class |
Oxidoreductases acting on CH-NH2 group of donors
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Target Validation |
T83875
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UniProt ID | |||||
EC Number |
EC 1.4.3.4
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Sequence |
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS |
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Drugs and Mode of Action | |||||
Drug(s) | Clorgyline | Drug Info | Approved | Parkinson's disease; Major depressive disorder | [537290], [541746], [551871] |
Isocarboxazid | Drug Info | Approved | Depression | [538453], [542218] | |
Moclobemide | Drug Info | Approved | Depression | [536361], [542451] | |
Tranylcypromine | Drug Info | Approved | Major depressive episode without melancholia | [551871] | |
Psoralen | Drug Info | Phase 3 | Discovery agent | [524054] | |
TRYPTAMINE | Drug Info | Phase 3 | Discovery agent | [521730], [538764] | |
CHF-3381 | Drug Info | Phase 2 | Neuropathic pain | [529017], [536374] | |
CX157 | Drug Info | Phase 2 | Mood disorder | [523264] | |
Ladostigil | Drug Info | Phase 2 | Alzheimer disease | [531772] | |
PIPERINE | Drug Info | Phase 1/2 | Vitiligo | [523529], [539613] | |
Desoxypeganine | Drug Info | Phase 1 | Alcohol use disorders | [529540] | |
Befloxatone | Drug Info | Discontinued in Phase 3 | Major depressive disorder | [541747], [544889] | |
Brofaromine | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [544708] | |
CS-722 | Drug Info | Discontinued in Phase 2 | Epilepsy | [545373] | |
ESUPRONE | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [545896] | |
RS-8359 | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [544693] | |
BW-1370U87 | Drug Info | Discontinued in Phase 1 | Major depressive disorder | [545298] | |
Bifemelane | Drug Info | Terminated | Alzheimer disease | [533445] | |
E-2011 | Drug Info | Terminated | Anxiety disorder | [545345] | |
Inhibitor | (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine | Drug Info | [530683] | ||
(+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one | Drug Info | [530683] | |||
(+/-)-2-(4'-Butoxyphenyl)thiomorpholine | Drug Info | [530683] | |||
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one | Drug Info | [530683] | |||
(+/-)-2-(4'-Ethoxyphenyl)thiomorpholine | Drug Info | [530683] | |||
(+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one | Drug Info | [530683] | |||
(+/-)-2-(4'-Methoxyphenyl)thiomorpholine | Drug Info | [530683] | |||
(+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one | Drug Info | [530683] | |||
(+/-)-2-(4'-Propoxyphenyl)thiomorpholine | Drug Info | [530683] | |||
(+/-)-2-Phenylthiomorpholin-5-one | Drug Info | [530683] | |||
(+/-)-2-Phenylthiomorpholine | Drug Info | [530683] | |||
(6-Benzyloxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
(6-Butoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
(6-Ethoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
(6-Methoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
(6-methylthio-2-naphthyl)isopropylamine | Drug Info | [529986] | |||
(6-Propoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
(7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile | Drug Info | [530434] | |||
(E)-5-(3-Chlorostyryl)isatin | Drug Info | [530056] | |||
(E)-5-(3-Fluorostyryl)isatin | Drug Info | [530056] | |||
(E)-5-Styrylisatin | Drug Info | [530056] | |||
(R)-Indan-1-yl-methyl-prop-2-ynyl-amine | Drug Info | [526455] | |||
(R,S)-N-(R-phenylethyl)-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
(R/R)BEFLOXATONE | Drug Info | [526287] | |||
(S)-2-amino-1-(4-butylthiophenyl)-propane | Drug Info | [528855] | |||
(S)-2-amino-1-(4-ethylthiophenyl)-propane | Drug Info | [528855] | |||
(S)-2-amino-1-(4-methylthiophenyl)-propane | Drug Info | [528855] | |||
(S)-2-amino-1-(4-propylthiophenyl)-propane | Drug Info | [528855] | |||
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole | Drug Info | [526994] | |||
1-(1-Naphthyl)-2-aminopropane | Drug Info | [529986] | |||
1-(2-Naphthyl)-2-aminopropane | Drug Info | [529986] | |||
1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine | Drug Info | [527928] | |||
1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine | Drug Info | [527928] | |||
1-(3-benzylquinoxalin-2-yl)hydrazine | Drug Info | [527928] | |||
1-(4-(benzyloxy)phenyl)propan-2-amine | Drug Info | [529986] | |||
1-(4-butoxyphenyl)propan-2-amine | Drug Info | [529986] | |||
1-(4-ethoxyphenyl)propan-2-amine | Drug Info | [529986] | |||
1-(4-propoxyphenyl)propan-2-amine | Drug Info | [529986] | |||
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole | Drug Info | [526993] | |||
2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole | Drug Info | [551222] | |||
2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole | Drug Info | [551222] | |||
2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidazole | Drug Info | [529853] | |||
2-(3-benzylquinoxalin-2-ylamino)ethanol | Drug Info | [527928] | |||
2-(4,5-dihydro-1H-imidazol-2-yl)quinoline | Drug Info | [529853] | |||
2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole | Drug Info | [529853] | |||
2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole | Drug Info | [528409] | |||
2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole | Drug Info | [529853] | |||
2-Amino-1-(4-methylthiophenyl)propane | Drug Info | [529986] | |||
2-BFi | Drug Info | [525733] | |||
2-Bromo-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
2-Chloro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
2-Chloro-N-(3-morpholinopropyl)nicotinamide | Drug Info | [530675] | |||
2-Furan-2-yl-4,5-dihydro-1H-imidazole | Drug Info | [526918] | |||
2-oxo-N-m-tolyl-2H-chromene-3-carboxamide | Drug Info | [530001] | |||
2-oxo-N-p-tolyl-2H-chromene-3-carboxamide | Drug Info | [530001] | |||
2-oxo-N-phenyl-2H-chromene-3-carboxamide | Drug Info | [530001] | |||
2-Phenethyl-4,5-dihydro-1H-imidazole | Drug Info | [526918] | |||
2-Phenoxymethyl-4,5-dihydro-1H-imidazole | Drug Info | [526918] | |||
2-phenyl-5H-indeno[1,2-d]pyrimidine | Drug Info | [529077] | |||
2-phenyl-9H-indeno[2,1-d]pyrimidine | Drug Info | [529077] | |||
2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide | Drug Info | [530434] | |||
3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin | Drug Info | [529735] | |||
3,4-Benzo-7-acetonyloxy-8-methoxycoumarin | Drug Info | [529735] | |||
3,4-Benzo-7-acetonyloxy-8-methylcoumarin | Drug Info | [529735] | |||
3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | Drug Info | [531067] | |||
3-aminoacetamido-4'-methylfuro[3,2-g]coumarin | Drug Info | [528005] | |||
3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine | Drug Info | [527928] | |||
3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide | Drug Info | [531067] | |||
3-methyl-2(1H)-thioxo-4(3H)-quinazolinone | Drug Info | [529873] | |||
4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin | Drug Info | [529735] | |||
4,9-Dihydro-3H-beta-carboline | Drug Info | [526994] | |||
4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid | Drug Info | [530001] | |||
4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one | Drug Info | [530434] | |||
4-Chloro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
4-Chloro-N-(3-morpholinopropyl)nicotinamide | Drug Info | [530675] | |||
4-methyl-2H-benzofuro[3,2-g]chromen-2-one | Drug Info | [528005] | |||
4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one | Drug Info | [529735] | |||
5,6-Dichloro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
5,6-Dichloro-N-(3-morpholinopropyl)nicotinamide | Drug Info | [530675] | |||
5-Azidomethyl-3-pyrrol-1-yl-oxazolidin-2-one | Drug Info | [526287] | |||
5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
5-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one | Drug Info | [526287] | |||
5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
5-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
5-Methoxymethyl-3-pyrrol-1-yl-oxazolidin-2-one | Drug Info | [526287] | |||
6,11-dihydro-5H-benzo[a]carbazole | Drug Info | [529077] | |||
6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one | Drug Info | [529735] | |||
6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
6-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
6-Chloro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
6-Chloro-N-(3-morpholinopropyl)nicotinamide | Drug Info | [530675] | |||
6-Fluoro-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
6-Hydroxy-N-(2-morpholinoethyl)nicotinamide | Drug Info | [530675] | |||
6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526994] | |||
6-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [526994] | |||
7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin | Drug Info | [529080] | |||
7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin | Drug Info | [529735] | |||
7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin | Drug Info | [529735] | |||
7-acetonyloxy-3-acetylamino-8-methoxycoumarin | Drug Info | [528005] | |||
7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
7-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | Drug Info | [551374] | |||
7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526918] | |||
7-Methoxy-9H-beta-carboline | Drug Info | [526993] | |||
8-(3-Bromobenzyloxy)caffeine | Drug Info | [530647] | |||
8-(3-Chlorobenzyloxy)caffeine | Drug Info | [530647] | |||
8-(3-Fluorobenzyloxy)caffeine | Drug Info | [530647] | |||
8-(3-Methoxybenzyloxy)caffeine | Drug Info | [530647] | |||
8-(3-Methylbenzyloxy)caffeine | Drug Info | [530647] | |||
8-Benzyloxycaffeine | Drug Info | [530647] | |||
8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
8-Bromo-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
8-Methoxy-4,9-dihydro-3H-beta-carboline | Drug Info | [526993] | |||
8-[(3-Trifluoromethyl)benzyloxy]caffeine | Drug Info | [530647] | |||
9-(3-aminopropoxy)-7H-furo[3,2-g]chromen-7-one | Drug Info | [528005] | |||
9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info | [526993] | |||
Befloxatone | Drug Info | [534110] | |||
Beta-methoxyamphetamine | Drug Info | [529986] | |||
BW-1370U87 | Drug Info | [533985], [551871] | |||
C-(1H-Indol-3-yl)-methylamine | Drug Info | [526993] | |||
CGS-19281A | Drug Info | [526994] | |||
CHF-3381 | Drug Info | [536374] | |||
Cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine | Drug Info | [529607] | |||
Cis-2-phenylcyclopropylamine | Drug Info | [529607] | |||
Clorgyline | Drug Info | [537290] | |||
CS-722 | Drug Info | [526826] | |||
CX157 | Drug Info | [530498] | |||
DECYL(DIMETHYL)PHOSPHINE OXIDE | Drug Info | [551374] | |||
ESUPRONE | Drug Info | [534393], [551871] | |||
Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate | Drug Info | [530001] | |||
FA-70 | Drug Info | [543637] | |||
Flavin-Adenine Dinucleotide | Drug Info | [551393] | |||
HARMINE | Drug Info | [530562] | |||
HYDRAZINECARBOXAMIDE | Drug Info | [527283] | |||
IPRONIAZIDE | Drug Info | [530675] | |||
Isocarboxazid | Drug Info | [537841] | |||
Isopsoralen | Drug Info | [535106] | |||
Ladostigil | Drug Info | [531772] | |||
Moclobemide | Drug Info | [535620] | |||
N'-(2-phenylallyl)hydrazine hydrochloride | Drug Info | [528105] | |||
N-((1H-indol-2-yl)methyl)(phenyl)methanamine | Drug Info | [529768] | |||
N-((1H-indol-2-yl)methyl)-2-phenylethanamine | Drug Info | [529768] | |||
N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine | Drug Info | [529768] | |||
N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine | Drug Info | [529768] | |||
N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine | Drug Info | [529768] | |||
N-(1H-Indol-2-ylmethyl)-N-phenylamine | Drug Info | [529768] | |||
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide | Drug Info | [531067] | |||
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-(2-Phenylethyl)-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-(3-Phenylpropyl)-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide | Drug Info | [530001] | |||
N-(4-Phenylbutyl)-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-(benzyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-(propargyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-2-phenylethyl-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-Benzyl,N-methyl-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
N-Benzyl-(6-methoxy-2-naphthyl)-2-aminopropane | Drug Info | [529986] | |||
N-Benzyl-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-benzyl-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine | Drug Info | [529768] | |||
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine | Drug Info | [528641] | |||
N-Methyl,N-phenyl-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-methyl-N-(prop-2-ynyl)-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-Phenyl-1-methyl-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-Phenyl-1H-indole-2-carboxamide | Drug Info | [529768] | |||
N-phenyl-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N-propargyl-1H-pyrrole-2-carboxamide | Drug Info | [528641] | |||
N2-[4-(benzyloxy)benzyl]glycinamide | Drug Info | [529025] | |||
N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide | Drug Info | [529025] | |||
N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide | Drug Info | [529025] | |||
NSC-656158 | Drug Info | [530662] | |||
Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate | Drug Info | [529853] | |||
PIPERINE | Drug Info | [530562] | |||
PNU-22394 | Drug Info | [526993] | |||
Psoralen | Drug Info | [535106] | |||
RS-8359 | Drug Info | [536146] | |||
TOLOXATONE | Drug Info | [528273] | |||
TRACIZOLINE | Drug Info | [526918] | |||
Trans-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine | Drug Info | [529607] | |||
Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine | Drug Info | [529607] | |||
Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine | Drug Info | [529607] | |||
Trans-2-fluoro-2-p-tolylcyclopropanamine | Drug Info | [529607] | |||
Trans-2-fluoro-2-phenylcyclopropylamin | Drug Info | [529607] | |||
Tranylcypromine | Drug Info | [536265], [537141] | |||
TRYPTAMINE | Drug Info | [526993] | |||
TRYPTOLINE | Drug Info | [526918] | |||
Antagonist | 4-Methoxyamphetamine | Drug Info | [551380] | ||
MMDA | Drug Info | [551393] | |||
Modulator | Bifemelane | Drug Info | [533445] | ||
Brofaromine | Drug Info | [533333] | |||
Desoxypeganine | Drug Info | [529540] | |||
E-2011 | Drug Info | [534616] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Dopamine degradation | |||||
Putrescine degradation III | |||||
Noradrenaline and adrenaline degradation | |||||
Serotonin degradation | |||||
Superpathway of melatonin degradation | |||||
Melatonin degradation II | |||||
KEGG Pathway | Glycine, serine and threonine metabolism | ||||
Arginine and proline metabolism | |||||
Histidine metabolism | |||||
Tyrosine metabolism | |||||
Phenylalanine metabolism | |||||
Tryptophan metabolism | |||||
Drug metabolism - cytochrome P450 | |||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Dopaminergic synapse | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Alcoholism | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
5-Hydroxytryptamine degredation | |||||
Dopamine receptor mediated signaling pathway | |||||
PathWhiz Pathway | Histidine Metabolism | ||||
Tyrosine Metabolism | |||||
Glycine and Serine Metabolism | |||||
Reactome | Norepinephrine Neurotransmitter Release Cycle | ||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Biogenic Amine Synthesis | |||||
Oxidative Stress | |||||
Dopamine metabolism | |||||
Phase 1 - Functionalization of compounds | |||||
Neurotransmitter Release Cycle | |||||
Neurotransmitter Clearance In The Synaptic Cleft | |||||
Serotonin Transporter Activity | |||||
References | |||||
Ref 521730 | ClinicalTrials.gov (NCT00227136) Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion. U.S. National Institutes of Health. | ||||
Ref 523264 | ClinicalTrials.gov (NCT01246908) Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression. U.S. National Institutes of Health. | ||||
Ref 523529 | ClinicalTrials.gov (NCT01383694) Effect Of Piperine In Patients With Oropharyngeal Dysphagia. U.S. National Institutes of Health. | ||||
Ref 524054 | ClinicalTrials.gov (NCT01686594) PUVA Maintenance Therapy in Mycosis Fungoides. U.S. National Institutes of Health. | ||||
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