Drug General Information
Drug ID	D0C1SE
Former ID	DNC004343
Drug Name	1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526994]
Structure		Download 2D MOL 3D MOL
Formula	C11H12N2
Canonical SMILES	C1CN2C(=CC3=CC=CC=C32)CN1
InChI	1S/C11H12N2/c1-2-4-11-9(3-1)7-10-8-12-5-6-13(10)11/h1-4,7,12H,5-6,8H2
InChIKey	AEIDURNZWCNQIM-UHFFFAOYSA-N
PubChem Compound ID	14595509
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[526994]
	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[526994]
	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[526994]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[526235]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[526994]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[526994]
BioCyc Pathway	Superpathway of tryptophan utilization
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa00260:Glycine, serine and threonine metabolism
	Alcoholismhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database	Alpha-synuclein signaling
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine Metabolism
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390666:Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter ActivityWP465:Tryptophan metabolism
	Phase 1 - Functionalization of compoundsWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 526994	Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Ref 526235	Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8.Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.
Ref 526994	Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.