Drug General Information
Drug ID
D0LI3J
Former ID
DNC012203
Drug Name
2-BFi
Synonyms
2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525733]
Structure
Download
2D MOL

3D MOL

Formula
C11H10N2O
PubChem Compound ID
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [525733]
Amine oxidase [flavin-containing] B Target Info Inhibitor [529853]
Alpha-2B adrenergic receptor Target Info Inhibitor [525733]
Amine oxidase [flavin-containing] A Target Info Inhibitor [525733]
Alpha-2C adrenergic receptor Target Info Inhibitor [525733]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00001:Adrenaline and noradrenaline biosynthesis
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP465:Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compoundsWP58:Monoamine GPCRs
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 525733Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Ref 525733Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Ref 529853Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.

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