| Drug General Information |
| Drug ID |
D0Y1GL
|
| Former ID |
DNC011684
|
| Drug Name |
8-Methoxy-4,9-dihydro-3H-beta-carboline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H12N2O
|
| Canonical SMILES |
COC1=CC=CC2=C1NC3=C2CCN=C3
|
| InChI |
1S/C12H12N2O/c1-15-11-4-2-3-9-8-5-6-13-7-10(8)14-12(9)11/h2-4,7,14H,5-6H2,1H3
|
| InChIKey |
LIUNAKJFUYIJFE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
| Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of tryptophan utilization
|
|
Tryptophan degradation via tryptamine
|
|
Dopamine degradation
|
|
Putrescine degradation III
|
|
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
|
|
Noradrenaline and adrenaline degradation
|
|
Serotonin degradation
|
|
Superpathway of melatonin degradation
|
|
Melatonin degradation II
|
|
KEGG Pathway
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Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa00260:Glycine, serine and threonine metabolism
|
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Arginine and proline metabolism
|
|
Histidine metabolism
|
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Tyrosine metabolism
|
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Phenylalanine metabolism
|
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Tryptophan metabolism
|
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Drug metabolism - cytochrome P450
|
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Metabolic pathways
|
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Dopaminergic synapse
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
|
|
Alcoholism
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
|
5-Hydroxytryptamine degredation
|
|
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
|
Dopamine receptor mediated signaling pathway
|
|
Pathway Interaction Database
|
Alpha-synuclein signaling
|
|
PathWhiz Pathway
|
Histidine Metabolism
|
|
Tyrosine Metabolism
|
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Glycine and Serine Metabolism
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release Cycle
|
|
WikiPathways
|
Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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SIDS Susceptibility Pathways
|
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Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR ligand binding
|
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GPCR downstream signaling
|
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GPCRs, OtherWP465:Tryptophan metabolism
|
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Dopamine metabolism
|
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Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways
|
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Biogenic Amine Synthesis
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Oxidative Stress
|
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Phase 1 - Functionalization of compounds
|
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Neurotransmitter Release Cycle
|
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Neurotransmitter Clearance In The Synaptic Cleft
|
|
Serotonin Transporter Activity
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
|---|
