| Drug General Information |
| Drug ID |
D08SCH
|
| Former ID |
DNC010641
|
| Drug Name |
2-Amino-1-(4-methylthiophenyl)propane
|
| Synonyms |
1-(6-(methylthio)naphthalen-2-yl)propan-2-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H15NS
|
| Canonical SMILES |
CC(CC1=CC=C(C=C1)SC)N
|
| InChI |
1S/C10H15NS/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6,8H,7,11H2,1-2H3
|
| InChIKey |
OLEWMKVPSUCNLG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[2]
|
|---|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[2]
|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[2]
|
| Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of tryptophan utilization
|
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Dopamine degradation
|
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Putrescine degradation III
|
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Noradrenaline and adrenaline degradation
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Serotonin degradation
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Superpathway of melatonin degradation
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Melatonin degradation II
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KEGG Pathway
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Serotonergic synapsehsa04728:Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
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Arginine and proline metabolism
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Histidine metabolism
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Tyrosine metabolism
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Phenylalanine metabolism
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Tryptophan metabolism
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Serotonergic synapse
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Dopaminergic synapse
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Alcoholism
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NetPath Pathway
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TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
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PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
|
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
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Parkinson disease
|
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Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
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5-Hydroxytryptamine degredation
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Dopamine receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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PathWhiz Pathway
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Histidine Metabolism
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Tyrosine Metabolism
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Glycine and Serine Metabolism
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-181430:Norepinephrine Neurotransmitter Release Cycle
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WikiPathways
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Monoamine Transport
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NRF2 pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP727:Monoamine Transport
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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Neurotransmitter Clearance In The Synaptic CleftWP706:SIDS Susceptibility Pathways
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Biogenic Amine Synthesis
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Oxidative Stress
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Dopamine metabolism
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Phase 1 - Functionalization of compounds
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Neurotransmitter Release Cycle
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Neurotransmitter Clearance In The Synaptic Cleft
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Serotonin Transporter Activity
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| References |
| REF 1 | Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. Epub 2009 Feb 8.Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. |
|---|
| REF 2 | Eur J Med Chem. 2009 Dec;44(12):4862-88. Epub 2009 Aug 6.Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. |
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