Target Validation Information
Target ID T93105
Target Name Presenilin 1
Target Type
Clinical Trial
Drug Potency against Target 1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one Drug Info IC50 = 1000 nM [528191]
(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone Drug Info IC50 = 1600 nM [528191]
Drug 311952 Drug Info IC50 = 26 nM [527143]
(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone Drug Info IC50 = 13900 nM [528191]
Drug 311383 Drug Info IC50 = 14 nM [527143]
1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene Drug Info IC50 = 461 nM [527542]
Drug 311951 Drug Info IC50 = 16 nM [527143]
Drug 311440 Drug Info IC50 = 9 nM [527143]
(5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone Drug Info IC50 = 10200 nM [528191]
References
Ref 528191Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Ref 528191Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 528191Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 527542Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8.Aryl sulfones: a new class of gamma-secretase inhibitors.
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 528191Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.

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