| Drug General Information |
| Drug ID |
D0XQ2T
|
| Former ID |
DNC005175
|
| Drug Name |
Drug 311440
|
| Synonyms |
311440
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Target and Pathway |
| Target(s) |
Presenilin 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Presenilin 1 |
Target Info |
Inhibitor |
[1]
|
| Gamma-secretase |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Notch signaling pathway
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Neurotrophin signaling pathway
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Alzheimer's diseasehsa04310:Wnt signaling pathway
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Alzheimer's diseasehsa04330:Notch signaling pathway
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Alzheimer's disease
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NetPath Pathway
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Notch Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Alzheimer disease-presenilin pathway
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Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Notch signaling pathway
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Pathway Interaction Database
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LKB1 signaling eventsnotch_pathway:Notch signaling pathway
|
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Presenilin action in Notch and Wnt signaling
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p75(NTR)-mediated signaling
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Syndecan-3-mediated signaling eventsnotch_pathway:Notch signaling pathway
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Syndecan-3-mediated signaling events
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Reactome
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Nuclear signaling by ERBB4
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Regulated proteolysis of p75NTR
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NRIF signals cell death from the nucleus
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Activated NOTCH1 Transmits Signal to the Nucleus
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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NOTCH2 Activation and Transmission of Signal to the Nucleus
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EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
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EPH-ephrin mediated repulsion of cells
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WikiPathways
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Notch Signaling Pathway
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Signaling by ERBB4
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Signaling by NOTCH3
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Signaling by NOTCH4
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Signaling by NOTCH1
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Signaling by NOTCH2
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Notch Signaling Pathway
|
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Alzheimers Disease
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Signalling by NGFWP61:Notch Signaling Pathway
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Alzheimers DiseaseWP61:Notch Signaling Pathway
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Signalling by NGF
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| References |
| REF 1 | J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. |
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