| Drug General Information |
| Drug ID |
D00DFR
|
| Former ID |
DNC006741
|
| Drug Name |
(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H20O3
|
| Canonical SMILES |
C1C=CC(=O)C(C1OCC2=CC=CC=C2)OCC3=CC=CC=C3
|
| InChI |
1S/C20H20O3/c21-18-12-7-13-19(22-14-16-8-3-1-4-9-16)20(18)23-15-17-10-5-2-6-11-17/h1-12,19-20H,13-15H2/t19-,20-/m1/s1
|
| InChIKey |
PHZAKVRYDXRMRQ-WOJBJXKFSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Gamma-secretase |
Target Info |
Inhibitor |
[1]
|
|---|
| Presenilin 1 |
Target Info |
Inhibitor |
[1]
|
| Presenilin 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Notch signaling pathway
|
|
Alzheimer's diseasehsa04310:Wnt signaling pathway
|
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Neurotrophin signaling pathway
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Alzheimer's diseasehsa04330:Notch signaling pathway
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Alzheimer's disease
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NetPath Pathway
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Notch Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Alzheimer disease-presenilin pathway
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Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Notch signaling pathway
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Pathway Interaction Database
|
Notch signaling pathway
|
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Presenilin action in Notch and Wnt signaling
|
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p75(NTR)-mediated signaling
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Syndecan-3-mediated signaling eventsnotch_pathway:Notch signaling pathway
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Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling events
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Reactome
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Nuclear signaling by ERBB4
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Regulated proteolysis of p75NTR
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NRIF signals cell death from the nucleus
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Activated NOTCH1 Transmits Signal to the Nucleus
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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NOTCH2 Activation and Transmission of Signal to the Nucleus
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EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
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EPH-ephrin mediated repulsion of cells
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WikiPathways
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Notch Signaling Pathway
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Signaling by ERBB4
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Signaling by NOTCH3
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Signaling by NOTCH4
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Signaling by NOTCH1
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Signaling by NOTCH2
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Notch Signaling Pathway
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Signalling by NGFWP61:Notch Signaling Pathway
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Alzheimers DiseaseWP61:Notch Signaling Pathway
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Alzheimers Disease
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Signalling by NGF
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| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. |
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