| Drug General Information |
| Drug ID |
D0M2LV
|
| Former ID |
DNC006737
|
| Drug Name |
(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H18O3
|
| Canonical SMILES |
COC1CCCC(=O)C1OCC2=CC=CC=C2
|
| InChI |
1S/C14H18O3/c1-16-13-9-5-8-12(15)14(13)17-10-11-6-3-2-4-7-11/h2-4,6-7,13-14H,5,8-10H2,1H3/t13-,14-/m1/s1
|
| InChIKey |
KUAHCCGAHBFAKU-ZIAGYGMSSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Presenilin 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Presenilin 1 |
Target Info |
Inhibitor |
[1]
|
| Gamma-secretase |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Notch signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Alzheimer's diseasehsa04310:Wnt signaling pathway
|
|
Alzheimer's diseasehsa04330:Notch signaling pathway
|
|
Alzheimer's disease
|
|
NetPath Pathway
|
Notch Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Alzheimer disease-presenilin pathway
|
|
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Notch signaling pathway
|
|
Pathway Interaction Database
|
LKB1 signaling eventsnotch_pathway:Notch signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
p75(NTR)-mediated signaling
|
|
Syndecan-3-mediated signaling eventsnotch_pathway:Notch signaling pathway
|
|
Syndecan-3-mediated signaling events
|
|
Reactome
|
Nuclear signaling by ERBB4
|
|
Regulated proteolysis of p75NTR
|
|
NRIF signals cell death from the nucleus
|
|
Activated NOTCH1 Transmits Signal to the Nucleus
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
|
NOTCH2 Activation and Transmission of Signal to the Nucleus
|
|
EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
|
|
EPH-ephrin mediated repulsion of cells
|
|
WikiPathways
|
Notch Signaling Pathway
|
|
Signaling by ERBB4
|
|
Signaling by NOTCH3
|
|
Signaling by NOTCH4
|
|
Signaling by NOTCH1
|
|
Signaling by NOTCH2
|
|
Notch Signaling Pathway
|
|
Alzheimers Disease
|
|
Signalling by NGFWP61:Notch Signaling Pathway
|
|
Alzheimers DiseaseWP61:Notch Signaling Pathway
|
|
Signalling by NGF
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. Epub 2006 May 8.Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. |
|---|
