Drug Information

Drug General Information
Drug ID
D02UVH
Former ID
DNC002425
Drug Name
B-Octylglucoside
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C14H28O6
Canonical SMILES
CCCCCCCCOC1C(C(C(C(O1)CO)O)O)O
InChI
1S/C14H28O6/c1-2-3-4-5-6-7-8-19-14-13(18)12(17)11(16)10(9-15)20-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1
InChIKey
HEGSGKPQLMEBJL-RKQHYHRCSA-N
PubChem Compound ID
62852
PubChem Substance ID
584280, 584291, 584502, 584647, 585869, 813225, 820187, 821369, 822092, 822097, 822455, 822691, 822702, 822788, 822794, 822795, 823843, 823846, 824855, 825420, 825590, 825596, 825599, 825943, 826391, 826438, 827538, 827540, 828754, 829208, 830059, 830125, 830492, 830570, 830755, 832901, 832903, 833551, 834448, 834461, 836814, 837232, 839078, 841302, 3139829, 6436210, 6436707, 7886299, 7887851, 8025150
Target and Pathway
Target(s) Gastric triacylglycerol lipase Target Info Inhibitor [551393]
Mineralocorticoid receptor Target Info Inhibitor [551393]
Triacylglycerol lipase, pancreatic Target Info Inhibitor [551393]
Lanosterol synthase Target Info Inhibitor [551393]
Prostaglandin G/H synthase 1 Target Info Inhibitor [551393]
Rhodopsin Target Info Inhibitor [551393]
Prostaglandin G/H synthase 2 Target Info Inhibitor [551393]
Apolipoprotein A-II Target Info Inhibitor [551393]
Cytochrome B Target Info Inhibitor [551393]
Glucocorticoid receptor Target Info Inhibitor [551393]
Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [551393]
Steryl-sulfatase Target Info Inhibitor [551393]
Mitogen-activated protein kinase 14 Target Info Inhibitor [551393]
Phospholipase A2, membrane associated Target Info Inhibitor [551393]
mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [551393]
Influenza A virus M2 protein Target Info Inhibitor [551393]
Nitric oxide synthase, inducible Target Info Inhibitor [551393]
BioCyc Pathway Triacylglycerol degradationLIPAS-PWY:Triacylglycerol degradation
Retinol biosynthesisPWY66-3:Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Cholesterol biosynthesis III (via desmosterol)
Cholesterol biosynthesis I
Superpathway of cholesterol biosynthesis
Lanosterol biosynthesisPWY66-374:C20 prostanoid biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
C20 prostanoid biosynthesis
Aspirin triggered resolvin E biosynthesisLIPASYN-PWY:PhospholipasesPWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway Glycerolipid metabolism
Metabolic pathways
Fat digestion and absorptionhsa04960:Aldosterone-regulated sodium reabsorptionhsa00561:Glycerolipid metabolism
Pancreatic secretion
Fat digestion and absorption
Vitamin digestion and absorptionhsa00100:Steroid biosynthesis
Biosynthesis of antibioticshsa00590:Arachidonic acid metabolism
Platelet activation
Serotonergic synapsehsa04744:Phototransductionhsa00590:Arachidonic acid metabolism
NF-kappa B signaling pathway
VEGF signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Leishmaniasis
Pathways in cancer
Chemical carcinogenesis
MicroRNAs in cancer
Small cell lung cancerhsa03320:PPAR signaling pathwaypfa00190:Oxidative phosphorylation
Metabolic pathwayshsa04080:Neuroactive ligand-receptor interactionhsa00240:Pyrimidine metabolism
Metabolic pathwayshsa00140:Steroid hormone biosynthesishsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Ras signaling pathway
Vascular smooth muscle contraction
Fat digestion and absorptionhsa04520:Adherens junction
Insulin signaling pathwayhsa00220:Arginine biosynthesis
Arginine and proline metabolism
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Amoebiasis
Small cell lung cancer
NetPath Pathway EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
TSH Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL5 Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Cholesterol biosynthesisP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00019:Endothelin signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Toll receptor signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
VEGF signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathway
CCKR signaling map STP00012:Cadherin signaling pathway
Pathway Interaction Database Visual signal transduction: Rodsnfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytes
S1P1 pathway
C-MYB transcription factor network
Signaling mediated by p38-alpha and p38-beta
Calcium signaling in the CD4+ TCR pathwaysmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor networkendothelinpathway:Endothelins
BCR signaling pathway
p73 transcription factor network
p38 MAPK signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
Rapid glucocorticoid signaling
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Retinoic acid receptors-mediated signaling
CXCR3-mediated signaling events
EPO signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinglypican_1pathway:Glypican 1 networkinsulin_pathway:Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling eventsil12_2pathway:IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
IL23-mediated signaling events
HIF-1-alpha transcription factor network
PathWhiz Pathway Kidney FunctionPW000050:Steroid BiosynthesisPW000044:Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000160:Pyrimidine MetabolismPW000045:Androgen and Estrogen MetabolismPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Retinoid metabolism and transportR-HSA-191273:Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)R-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling eventsR-HSA-174800:Chylomicron-mediated lipid transport
PPARA activates gene expression
Retinoid metabolism and transportR-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-500753:Pyrimidine biosynthesisR-HSA-1660662:Glycosphingolipid metabolismR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-354192:Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signalingR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Triacylglyceride Synthesis
Fatty Acid Beta OxidationWP554:ACE Inhibitor PathwayWP2776:Visual phototransduction
Lipid digestion, mobilization, and transportWP2706:Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
Cholesterol biosynthesisWP98:Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient NetworkWP455:GPCRs, Class A Rhodopsin-like
Visual phototransduction
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Integrin-mediated Cell AdhesionWP98:Prostaglandin Synthesis and Regulation
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
Statin Pathway
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Lipid digestion, mobilization, and transportWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear ReceptorsWP1851:Metabolism of nucleotidesWP697:Estrogen metabolism
Vitamin D Receptor Pathway
Sphingolipid metabolismWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
IL-4 Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
BDNF signaling pathway
Oncostatin M Signaling Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP2795:Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
MicroRNAs in cardiomyocyte hypertrophyWP481:Insulin Signaling
Growth hormone receptor signaling
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP2683:Influenza Life CycleWP619:Type II interferon signaling (IFNG)
Effects of Nitric Oxide
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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